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Covalent attachment of 1,4-dioxane to beta born of ferracarborane sandwich complexes which can be easily outfitted with many organic functional groups. Procedure worked as reported, with moderate yields of 60-70%. Higher yields were achieved at smaller scales...
Summary:
An efficient and environmentally benign method for synthesis of 1,2-disubstituted and 2 substituted benzimidazoles has been described. Although previous methods are available in literature for synthesis of such compounds, the ease of operation,...
Summary:
This paper reports the synthesis of 2-arylbenzothiazoles via cyclocondensation of 2-aminothiophenol with various aldehydes. Polyethylene glycol-400 (PEG-400) has been used as both solvent and catalyst for the process. The procedure applied, is...
Summary:
This paper describes the conceptual density functional studies on (3+1) complexes of both Re(V) as well as Tc(V). The tridentate ligands have been varied in order to study the effect of the various combinations of N, O and S chelating sites on...
This paper describes synthesis, characterization, and catalase activity of a water-soluble diMn(III) complex of a sulphonato-substituted Schiff-base ligand. DiMn(III) complex is highly efficient to disproportionate hydrogen peroxide in basic aqueous solutions...
This article describes an efficient method for solution-phase parallel synthesis of 2-quinoxalinol salen Schiff-base ligands. The novelty of this article is the synthesis of a new category of ligands using Schiff-base condensation of an aldehyde with a...
The authors describe the syntheses of several optically pure [3+4] cycloaddition product from the reaction of racemic azomethine imines and enals using indanol-derived catalyst D having N-mesityl substituent. This work pertains to the development of...
The coupling reaction between a carboxylic acid and an alcohol to generate an ester needs a carbodiimide coupling agent. in the reference, the authors report the use of EDCI to prepare compound 1. I have used the same procedure in the synthesis of 1 though...
I need prepare a series of 2-amino-pyridines around 2003, and found this paper by SciFinder.
I tested the reaction of 1-Boc-piperidine and 2-chloro-3-methyl- pyridine in 50mg scale using 5 mmol% catalysts.
The reactions were not completed in 3h at rt....
This paper by Verkade and co-workers describes a superbase P(MeNCH2CH2)3N mediated selective monoalkylation of active-methylene compounds. Although malonate alkylation has been known for many years, it is very difficult to obtain really good yields for...
This work by Lafrance and co-work represents a very mild means to induce the decarboxylation of malonic acid derivatives with 1,1-carbonyldiimidazole (CDI). The reactive intermediate carbonyl imidazole moiety can be trapped with various nucleophiles in an...
I used the published synthethic methods for both deoxy and methoxy derivatives with some modifications and obtained a lot higher yields.
Deoxy: 2 eq of 1,1′-Thiocarbonyldiimidazole is enough (paper is 2.5 eq) and I used 1,2-dichloroethane instead of CH2Cl2...
The methodology described in this article is very valuable for scientists working with glycosphingolipids. It provided a one-pot syntheses of alpha-linked glycolipids with the possibility of using substrates with unsaturations in the fatty acid side...
In one of my Ph.D. projects where I was working on the total syntheses of glycosphingolipids, I followed this reference to prepare some of the intermediates. This is a very important publication in the glycolipid field since it is among the few papers that...
Synthesized 2,6-Bis(3-dodecylthiophen-2-yl)benzobisthiazole following the procedure.
(1) The reaction was reproduced with higher yields (>25%).
(2) Added the 2-carboxylaldehydethiophene derviative by portions, used longer reaction time (24hs) and...
This article reported the synthesis of different sulfonyl chloride of polynuclear heterocyclic compounds which are very important intermediates to form different derivatives like sulfonates. Unfortunately, this paper is lacking a complete isolation and...
After searching for an alternate protecting group for the protection of cis-dihydrocatechols, it was found that the butane-bisacetals were more resilient to hydrolysis. This is crucial when protecting group stabiity is required for acetals that are exposed to...
Summary:
A practical synthesis of 11-membered C2-symmetric binaphthyl ketone (R)-1, a catalyst for asymmetric epoxidation, was developed. This manuscript describes the single example of chiral resolution of (±)-1,1’-Binaphthyl-2,2’-dicarboxylic acid [(±)-6...
Ureas are very widely used synthetic targets in pharmaceutical industry especially as kinase inhibitors. Using this methodology we have synthesized thousands of unsymmetrical ureas as kinase inhibitors. This method is a very mild, high yielding and can work...
Review: Synthesized the same compound of Dioxane-Monochloroborane by the reaction of Sodium Borohydride with Dioxane-borontrichloride (experimental section, Page 5364). I found the equivalency of the reagents is very important for this reaction. The reaction...