Under nitrogen, 1,3-dichlorobenzene (1 mmol) and 1,3-diaminobenzene were dissolved in toluene (15 mL). Sodium-tert-butoxide (NaO-t-Bu) (3 mmol), Ni(cod)2 (0.1 mmol), and DPPF (0.3mmol) were added to the solution at room temperature. The reaction mixture was...
Authours: Jean-Luc Montchamp, Feng Tian, Matthew E. Hart, and J. W. Frost*
Journal: J. Org. Chem. 1996, 61, 3897-3899
After searching for an alternate protecting group for the protection of cis-dihydrocatechols, it was found that the butane-bisacetals...
Synthesized (10) on beach in the lab and also pilot plant when I was working in company. The synthesis procedue is reproducible even in a 5 L scale reaction in the lab. The starting material L-Xylose canot be abtained from natural substances which results...
Tanner et al. has reported the silastannation reaction of several secondary terminal propargylic alcohols (protected and unprotected) with Pd2(dba)3·CHCl3/ Ph3P (1-2 equivalents of per Pd). Excellent regio and stereoselectivity (cis addition with tin always...
The hydrostannation of alkynes is frequently used for the synthesis of vinyl stannanes, which can be subjected to further modifications via a Stille coupling. The major drawbacks of this process result from the difficulties which arise in the control of the...
The article presents a facile and practical method to prepare fluorinated nucleosides, which are known for antitumor and antiviral activity, through introducing fluorine at the up-side of the 2’-carbon of nucleosides.
Particularly, I used this synthetic...
The article presents a facile and practical method to prepare fluorinated nucleosides, which are known for antitumor and antiviral activity, through introducing fluorine at the up-side of the 2’-carbon of nucleosides.
Particularly, I used this...
In this manuscript, the single crystalline wires were grown from π-extended porphyrin derivatives TTPH2 1 and TTPZn 2, and their unique electronic properties in OFET devices along with single-crystal structures. 1 was readily obtained in relatively high...
I used this published synthetic method for making similar N-alkylated benzodiazepine molecules. The reaction was very reliable and good yielding in case of exact molecule but in my molecule, which was basically 1,4-benzodiazepine-2-one derivative, this...
The methodology developed by Montchamp and co-workers demonstrated a mild and reliable way to esterify the monosubstituted phosphinic acids.
I repeated the preparation of substrate 3 as the entry 5 in table 1 followed their protocol. The reaction...
Chun Liu and Weibo Yang
Chem. Commun., 2009, 6267-6269
DOI: 10.1039/B912364D
Synthesized similar structures to (13)- "4'-bromo-2',3,5,6'-tetramethoxy-[1,1'-biphenyl]-4-yl trifluoromethanesulfonate" and also other subtitude functional group on 2',3,5,6' position- using the same procedures as are written in the paper in Supporting...
Yapin Wang
Emaill: ywang2@lsuhsc.edu
1) Reaction of Standard Condition
Using photo-induced (hn 254), copper- catalyzed (10% CuI), two ratio base(LiOt-Bu), CH3CN/DMF as solvents and
stirring for 24 hrs at room temperature, Amides react with inactivated...
A detailed route for the synthesis of the "S" enantiomer of 4-TIPS-3-butyn-2-ol in 90% enantiomeric purity by reduction of the ynone precursor by the Noyori catalytic system was reported by Marshall et al. The ease of catalyst preparation, operational...
H. Kondo and E. Ochiai Ann. Chem. 1929 470 p224 reported using the iodo group to block Pschorr diazonium cyclizations into an aromatic carbon position when making polycyclic aromatics. This protocol was repeated by K. Goto and H. Sudzuki Bull. Chem. Soc. Jpn...
Review:
This article/communication described the preapration of 2 and 4-quinolinecarboxaldehyde using 2 and 4-methylquinoline in the presence of selenous acid in refluxing dioxane. While the procedure explicitly stated the use of selenous acid, selenium...
The manuscript entitled ''A cyclic triphenylamine dimer for organic field-effect transistors with high performance'' is a nice piece of work. A new OFET based on triphenylamine units with a macrocyclic architect has been described with its potential use as...
Synthesized (20) using the similar (not exactly same) procedure (Scheme 2) as was written in the paper.
1,4-Diaminobutane was firstly protected by mesitly chloride in DCM (overnight under reflux condition). The protected intermediate was then...
The article is about versatile synthetic strategy for preparing enantiomerically pure (N)-methanocarba ring containing monophosphates as a potent agonist for P2 receptors.
I have successfully reproduced the synthesis of compound (2, MRS2339) from...
The procedure was adapted for the covalent attachment of an organometallic complex to chitosan backbone for use in a glucose oxidase bioanode. The procedure was done in both acidic (as in paper) and basic conditions (for comparison) for the following...