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Photoinduced, Copper-Catalyzed Alkylation of Amides with Unactivated Secondary Alkyl Halides at Room Temperature


01 Nov 2016

Coupling N-alkylation of Amides with Secondary Alkyl Halides

Yapin Wang

Emaill: ywang2@lsuhsc.edu

1) Reaction of Standard Condition
Using photo-induced (hn 254), copper- catalyzed (10% CuI), two ratio base(LiOt-Bu), CH3CN/DMF as solvents and
stirring for 24 hrs at room temperature, Amides react with inactivated...

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(R)- and (S)-4-TIPS-3-butyn-2-ol. Useful Precursors of Chiral Allenylzinc and Indium Reagents


01 Nov 2016

Synthesis of the optically active TIPS-functionalized acetylenic alcohols

A detailed route for the synthesis of the "S" enantiomer of 4-TIPS-3-butyn-2-ol in 90% enantiomeric purity by reduction of the ynone precursor by the Noyori catalytic system was reported by Marshall et al. The ease of catalyst preparation, operational...

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Über die Konstitution des Sinomenins


01 Nov 2016

Blocking diazonium couplings of aromatic rings

H. Kondo and E. Ochiai Ann. Chem. 1929 470 p224 reported using the iodo group to block Pschorr diazonium cyclizations into an aromatic carbon position when making polycyclic aromatics.  This protocol was repeated by K. Goto and H. Sudzuki Bull. Chem. Soc. Jpn...

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A New Approach to the Oxidation of Methylquinolines with Selenium Dioxide


01 Nov 2016

4-methylquinoline oxidation really works

Review:

This article/communication described the preapration of 2 and 4-quinolinecarboxaldehyde using 2 and 4-methylquinoline in the presence of selenous acid in refluxing dioxane. While the procedure explicitly stated the use of selenous acid, selenium...

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A Cyclic Triphenylamine Dimer for Organic Field-Effect Transistors with High Performance


01 Nov 2016

Review of the novel materials for future organic electronics

The manuscript entitled ''A cyclic triphenylamine dimer for organic field-effect transistors with high performance'' is a nice piece of work. A new OFET based on triphenylamine units with a macrocyclic architect has been described with its potential use as...

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Alkyl-Substituted Polyaminohydroxamic Acids:  A Novel Class of Targeted Histone Deacetylase Inhibitors


01 Nov 2016

Reproducible synthesis of compound 20

Synthesized (20) using the similar (not exactly same) procedure (Scheme 2) as was written in the paper.

1,4-Diaminobutane was firstly protected by mesitly chloride in DCM (overnight under reflux condition). The protected intermediate was then...

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Synthesis of Ethyl (1S,2R,3S,4S,5S)-2,3-O-(Isopropylidene)-4-Hydroxy-Bicyclo[3.1.0]Hexane-Carboxylate from L-Ribose: A Versatile Chiral Synthon for Preparation of Adenosine and P2 Receptor Ligands


01 Nov 2016

Convenient and reproducible synthetic methodology for North configured ribose containing mono phosphate

The article is about versatile synthetic strategy for preparing enantiomerically pure (N)-methanocarba ring containing monophosphates as a potent agonist for P2 receptors. 

I have successfully reproduced the synthesis of compound (2, MRS2339) from...

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Preparation and characterisation of fluorescent chitosans using 9-anthraldehyde as fluorophore


01 Nov 2016

Quality paper, good reproducibility


The procedure was adapted for the covalent attachment of an organometallic complex to chitosan backbone for use in a glucose oxidase bioanode. The procedure was done in both acidic (as in paper) and basic conditions (for comparison) for the following...

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Versatile Routes to Mono- and Bis(alkynyl) Manganese(II) and Manganese(III) Complexes via Manganocenes


01 Nov 2016

stanylation terminal hydrogen at ethynyl aryls

Unseld et al reported a novel mono and bis (alkynyl) Mn(II) and Mn(III) complexes with terminal or trimetyltin substituted acetylenes. In particular I was interested on stanylation terminal hydrogen at ethynyl aryls. I used this approach to stanylate...

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Synthesis of Sulfated Neoglycopolymers:  Selective P-Selectin Inhibitors


01 Nov 2016

Ron Okoth

I adopted the synthesis reported in the paper for selective sulfation of compound 2 in the synthesis of 3’O Sulfo β-methyl D-galactoside similar in structure to compound 2 save for a methyl group at the anomeric position in place of an azidoethyl. I altered...

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