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Preparation of meta-polyaniline and its related poly(iminoarylene)s by nickel-catalyzed polycondensation of aryl dichlorides with aryl primary diamines


09 Dec 2016

Synthesis of poly(m-aniline) Table 1, Run 1

Under nitrogen, 1,3-dichlorobenzene (1 mmol) and 1,3-diaminobenzene were dissolved in toluene (15 mL). Sodium-tert-butoxide (NaO-t-Bu) (3 mmol), Ni(cod)2 (0.1 mmol), and DPPF (0.3mmol) were added to the solution at room temperature. The reaction mixture was...

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1,1'-Carbonylbis(3-methylimidazolium) triflate: an efficient reagent for aminoacylations


23 Nov 2016

Butane 2,3-Bisacetal Protection of Vicinal Diequatorial Diols

Authours: Jean-Luc Montchamp, Feng Tian, Matthew E. Hart, and J. W. Frost* 

Journal: J. Org. Chem. 1996, 61, 3897-3899 

After searching for an alternate protecting group for the protection of cis-dihydrocatechols, it was found that the butane-bisacetals...

(1)

Structure−Activity Relationships of 1-(2-Deoxy-2-fluoro-β- l -arabino- furanosyl)pyrimidine Nucleosides as Anti-Hepatitis B Virus Agents


01 Nov 2016

reproducible synthesis process

Synthesized (10) on beach in the lab and also pilot plant when I was working in company. The synthesis procedue is reproducible even in a 5 L scale reaction in the lab.  The starting material L-Xylose canot be abtained from natural substances which results...

(2)

Palladium-Catalyzed Silastannation of Secondary Propargylic Alcohols and their Derivatives


01 Nov 2016

Pd-catalyzed element-element addition to alkynes-a route to bis-functionalized alkenes

Tanner et al. has reported the silastannation reaction of several secondary terminal propargylic alcohols (protected and unprotected) with Pd2(dba)3·CHCl3/ Ph3P (1-2 equivalents of per Pd). Excellent regio and stereoselectivity (cis addition with tin always...

(2)

Mo(CO) 3 (CN- t- Bu) 3 (MoBI 3 ), a New Efficient Catalyst for Regioselective Hydrostannations


01 Nov 2016

Hydrostannation of Terminal Acetylenes

The hydrostannation of alkynes is frequently used for the synthesis of vinyl stannanes, which can be subjected to further modifications via a Stille coupling. The major drawbacks of this process result from the difficulties which arise in the control of the...

(1)

Synthesis of 9-(2-deoxy-2-fluoro--D-arabinofuranosyl)adenine bearing a selectively removable protecting group


01 Nov 2016

Synthesis of 2'-fluorinated Adenosine

The article presents a facile and practical method to prepare fluorinated nucleosides, which are known for antitumor and antiviral activity, through introducing fluorine at the up-side of the 2’-carbon of nucleosides.

Particularly, I used this synthetic...

(2)

Synthesis of 9-(2-Deoxy-2-fluoro-.BETA.-D-arabinofuranosyl)adenine Bearing a Selectively Removable Protecting Group.


01 Nov 2016

Synthesis of 2'-fluorinated nucleosides

The article presents a facile and practical method to prepare fluorinated nucleosides, which are known for antitumor and antiviral activity, through introducing fluorine at the up-side of the 2’-carbon of nucleosides.

 

Particularly, I used this...

(2)

High-Performance Single-Crystal-Based Organic Field-Effect Transistors from π-Extended Porphyrin Derivatives


01 Nov 2016

single crystal porphrins based organic materials

In this manuscript, the single crystalline wires were grown from π-extended porphyrin derivatives TTPH2 1  and TTPZn 2, and their unique electronic properties in OFET devices along with single-crystal structures. was readily obtained in relatively high...

(2)

Palladium-Catalysed Synthesis of Enantiopure 1,2,4,5-Tetrahydro-1,4-benzodiazepin-3-(3H)-one Derivatives


01 Nov 2016

Synthesis of N-alkylated Benzodiazepines

I used this published synthetic method for making similar N-alkylated benzodiazepine molecules. The reaction was very reliable and good yielding in case of exact molecule but in my molecule, which was basically 1,4-benzodiazepine-2-one derivative, this...

(1)

Orthosilicate-Mediated Esterification of Monosubstituted Phosphinic Acids


01 Nov 2016

Orthosilicate-Mediated Esterification of Monosubstituted Phosphinic Acids

The methodology developed by Montchamp and co-workers demonstrated a mild and reliable way to esterify the monosubstituted phosphinic acids.

 

I repeated the preparation of substrate 3 as the entry 5 in table 1 followed their protocol.  The reaction...

(1)

Symmetry and polar-π effects on the dynamics of enshrouded aryl-alkyne molecular rotors


01 Nov 2016

reproducible process and yield

Synthesized similar structures to (13)- "4'-bromo-2',3,5,6'-tetramethoxy-[1,1'-biphenyl]-4-yl trifluoromethanesulfonate" and also other subtitude functional group on 2',3,5,6' position- using the same procedures as are written in the paper in Supporting...

(1)

Photoinduced, Copper-Catalyzed Alkylation of Amides with Unactivated Secondary Alkyl Halides at Room Temperature


01 Nov 2016

Coupling N-alkylation of Amides with Secondary Alkyl Halides

Yapin Wang

Emaill: ywang2@lsuhsc.edu

1) Reaction of Standard Condition
Using photo-induced (hn 254), copper- catalyzed (10% CuI), two ratio base(LiOt-Bu), CH3CN/DMF as solvents and
stirring for 24 hrs at room temperature, Amides react with inactivated...

(0)

(R)- and (S)-4-TIPS-3-butyn-2-ol. Useful Precursors of Chiral Allenylzinc and Indium Reagents


01 Nov 2016

Synthesis of the optically active TIPS-functionalized acetylenic alcohols

A detailed route for the synthesis of the "S" enantiomer of 4-TIPS-3-butyn-2-ol in 90% enantiomeric purity by reduction of the ynone precursor by the Noyori catalytic system was reported by Marshall et al. The ease of catalyst preparation, operational...

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Über die Konstitution des Sinomenins


01 Nov 2016

Blocking diazonium couplings of aromatic rings

H. Kondo and E. Ochiai Ann. Chem. 1929 470 p224 reported using the iodo group to block Pschorr diazonium cyclizations into an aromatic carbon position when making polycyclic aromatics.  This protocol was repeated by K. Goto and H. Sudzuki Bull. Chem. Soc. Jpn...

(1)

A New Approach to the Oxidation of Methylquinolines with Selenium Dioxide


01 Nov 2016

4-methylquinoline oxidation really works

Review:

This article/communication described the preapration of 2 and 4-quinolinecarboxaldehyde using 2 and 4-methylquinoline in the presence of selenous acid in refluxing dioxane. While the procedure explicitly stated the use of selenous acid, selenium...

(1)

A Cyclic Triphenylamine Dimer for Organic Field-Effect Transistors with High Performance


01 Nov 2016

Review of the novel materials for future organic electronics

The manuscript entitled ''A cyclic triphenylamine dimer for organic field-effect transistors with high performance'' is a nice piece of work. A new OFET based on triphenylamine units with a macrocyclic architect has been described with its potential use as...

(1)

Alkyl-Substituted Polyaminohydroxamic Acids:  A Novel Class of Targeted Histone Deacetylase Inhibitors


01 Nov 2016

Reproducible synthesis of compound 20

Synthesized (20) using the similar (not exactly same) procedure (Scheme 2) as was written in the paper.

1,4-Diaminobutane was firstly protected by mesitly chloride in DCM (overnight under reflux condition). The protected intermediate was then...

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Synthesis of Ethyl (1S,2R,3S,4S,5S)-2,3-O-(Isopropylidene)-4-Hydroxy-Bicyclo[3.1.0]Hexane-Carboxylate from L-Ribose: A Versatile Chiral Synthon for Preparation of Adenosine and P2 Receptor Ligands


01 Nov 2016

Convenient and reproducible synthetic methodology for North configured ribose containing mono phosphate

The article is about versatile synthetic strategy for preparing enantiomerically pure (N)-methanocarba ring containing monophosphates as a potent agonist for P2 receptors. 

I have successfully reproduced the synthesis of compound (2, MRS2339) from...

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Preparation and characterisation of fluorescent chitosans using 9-anthraldehyde as fluorophore


01 Nov 2016

Quality paper, good reproducibility


The procedure was adapted for the covalent attachment of an organometallic complex to chitosan backbone for use in a glucose oxidase bioanode. The procedure was done in both acidic (as in paper) and basic conditions (for comparison) for the following...

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