This work by Lafrance and co-work represents a very mild means to induce the decarboxylation of malonic acid derivatives with 1,1-carbonyldiimidazole (CDI). The reactive intermediate carbonyl imidazole moiety can be trapped with various nucleophiles in an...
I used the published synthethic methods for both deoxy and methoxy derivatives with some modifications and obtained a lot higher yields.
Deoxy: 2 eq of 1,1′-Thiocarbonyldiimidazole is enough (paper is 2.5 eq) and I used 1,2-dichloroethane instead of CH2Cl2...
The methodology described in this article is very valuable for scientists working with glycosphingolipids. It provided a one-pot syntheses of alpha-linked glycolipids with the possibility of using substrates with unsaturations in the fatty acid side...
In one of my Ph.D. projects where I was working on the total syntheses of glycosphingolipids, I followed this reference to prepare some of the intermediates. This is a very important publication in the glycolipid field since it is among the few papers that...
Synthesized 2,6-Bis(3-dodecylthiophen-2-yl)benzobisthiazole following the procedure.
(1) The reaction was reproduced with higher yields (>25%).
(2) Added the 2-carboxylaldehydethiophene derviative by portions, used longer reaction time (24hs) and...
This article reported the synthesis of different sulfonyl chloride of polynuclear heterocyclic compounds which are very important intermediates to form different derivatives like sulfonates. Unfortunately, this paper is lacking a complete isolation and...
After searching for an alternate protecting group for the protection of cis-dihydrocatechols, it was found that the butane-bisacetals were more resilient to hydrolysis. This is crucial when protecting group stabiity is required for acetals that are exposed to...
Summary:
A practical synthesis of 11-membered C2-symmetric binaphthyl ketone (R)-1, a catalyst for asymmetric epoxidation, was developed. This manuscript describes the single example of chiral resolution of (±)-1,1’-Binaphthyl-2,2’-dicarboxylic acid [(±)-6...
Ureas are very widely used synthetic targets in pharmaceutical industry especially as kinase inhibitors. Using this methodology we have synthesized thousands of unsymmetrical ureas as kinase inhibitors. This method is a very mild, high yielding and can work...
Review: Synthesized the same compound of Dioxane-Monochloroborane by the reaction of Sodium Borohydride with Dioxane-borontrichloride (experimental section, Page 5364). I found the equivalency of the reagents is very important for this reaction. The reaction...
Victor E. Marquez et. al. first introduced the concept of locked conformations, 2'-exo (North) and 3'-exo (South), of ribose ring in nucleosides. In this article the synthetic methodology and successful synthesis of receamic and conformationally locked South...
Wanting to avoid a chromatographic separation of the Me esters as well as the greater expense of dimethyl itaconate, the reaction of alpha methyl benzylamine and itaconic acid was performed in xylene. The reaction was performed by adding the amine at 110 to...
The article reports the catalytic isomerization of the branched cyanoolefin 2-methyl-3-butenenitrile (2M3BN) to the linear isomer 3-pentenenitrile (3PN) using nickel-phosphine complexes.
The authors report that the optimal catalytic experiment was carried...
Summary: The paper discusses the synthesis, reactivity and stability of α-lithio N,N dimethylacetamide.
The paper described carefully the use of various solvents (pentane, THF) and their impact on the formation of the desired product.
It also described...
Summary
The article describes the synthesis of cyclen based chelators which can accommodate and stabilize di-and trivalent metal ions for biomedical applications. The chelators were synthesized first by monoalkylating cyclen (1,4,7,10...
The procedure described in this paper is very reliable. The ozone should be used in a fully functional fume hood as described.
1. Synthesized 10.1 g of crude diphenaldehyde starting from 10.0 g of phenanthrene.
2. The crude 1H-NMR of product is 80%...
In this paper, selective bromination of perylene diimides is described. I was able to reproduce the bromination of 1a. However, the workup involves evaporating large volumes of bromine. I was able to isolate similar yields of products by quenching the...
Synthesized (3) and a compound similar to (4) but with protection on -OH groups.
For (3): Dissolving CBr4 in dichloromethane instead of pyridine gave a better yield as it involved using only one solvent throughout the reaction.
For (4): The formation...
Summary:
The first simple cyclic silyl peroxide, namely 1,1,4,4,-tetramethyl-1,4-disila-2,3-dioxane, was prepared by classical synthetic methodology from its corresponding cyclic disilazane and the urea complex of hydrogen peroxide.
The Reaction of...
This paper describes amazingly shortest synthesis for such a complex macrolide. Geldanamycin was synthesized in 20 steps using key steps such as Cu-catalyzed intramolecular amidation. I have used synthetic strategy to synthesize prodrug of geldanamycin with...