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Hydrodeoxygenation of acetic acid in a microreactor


01 Jan 2017

Feasible and efficient process. Easily reproducible.

Summary:

This study reports the hydrodeoxygenation (HDO) of acetic acid. The authors have chosen a packed bed microreactor for the purpose. The reason for put forward by the authors for choosing micro reactor is its efficiency in operation under reduced...

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“On water” organic synthesis: a highly efficient and clean synthesis of 2-aryl/heteroaryl/styryl benzothiazoles and 2-alkyl/aryl alkyl benzothiazolines


01 Jan 2017

Excellent practical method. Highly recommended.

Summary:

A convenient, clean and environmentally benign method for ‘‘on water’’ synthesis of benzothiazoles/benzothiazolines has been described. Although previous methods are available in literature for synthesis of such compounds, the ease of operation,...

(0)

Selective quenching of benzimidazole derivatives by Cu2+ metal ion


01 Jan 2017

Many details omitted which makes it clumsy to repeat

Summary:

This paper reports the binding effect of some novel benzimidazole derivatives with Cu2+ metal ion by solution spectral studies. Benzimidazole complexes (16) were studied for fluorescence quenching by Cu2+ in comparison to Fe3+, Mg2+, Ag+, K+...

(0)

Synthesis, structure and study of azo-hydrazone tautomeric equilibrium of 1,3-dimethyl-5-(arylazo)-6-amino-uracil derivatives


24 Dec 2016

Lives up to the claims by the authors

Summary:

This paper reports the synthesis of hexamethylenebisacetamide (HMBA) without organic solvent or gas protection via amide exchange reaction of hexamethylenediamine (HDA) with CH3CN and H2O catalysed by CuO. The authors report the method to be more...

(0)

Oxorhenium-catalyzed deoxydehydration of glycols and epoxides


24 Dec 2016

Average reactions. Toxic solvents.

Summary:

Deoxydehydration of glycols and epoxides catalysed by oxorhenium complexes is described in this paper. Methyl trioxorhenium (MTO) was the choice as the catalyst for the reactions. The use of other catalytic conditions for such reactions are...

(0)

Nano ceria catalyzed synthesis of substituted benzimidazole, benzothiazole, and benzoxazole in aqueous media


24 Dec 2016

Work is good, descriptions could be better

Summary:

This paper reports a methodology for synthesis of substituted benzimidazole, benzothiazole, and benzoxazole in aqueous media. The method is novel in its approach of utilizing water as the medium, making it fit for a green chemistry protocol. The...

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A mild and efficient amide formation reaction mediated by P(OEt)3and iodine


24 Dec 2016

Reproducible reactions. Can be extended to other analouges

Summary:

This paper describes a novel method for efficient synthesis of amides through reaction of carboxylic acids with amines by activation with P(OEt)3 and Iodine. The novelty lies in easy amidation of several primary and secondary amines to synthesize...

(0)

Markovnikov Alkyne Hydrosilylation Catalyzed by Ruthenium Complexes


24 Dec 2016

trans-hydrosilylation internal alkynes: notes/modifications

Summary:

Trost and Ball discovered the efficient Ru-catalyst for Markovnikov hydrosilylation of terminal alkynes as well as trans-hydrosilylation of internal alkynes. This reaction is the only general method for accessing geminal alkenylsilanes via ...

(3)

Method and basis set analysis of oxorhenium(V) complexes for theoretical calculations


24 Dec 2016

Well established computational procedure

Summary:

This paper describes the analysis of methods and basis sets for theoretical calculations on oxorhenium(V) complexes. A variety of ligand systems with different coordinating atoms (N, O, P, S, Cl, and Se) were incorporated into this study. Two...

(2)

Efficient Route for Cyclic Olefin Polymerization:  Nonchelated Monodentate Benzimidazole Nickel(II) Complex Catalysts for Vinyl Polymerization of Norbornene


24 Dec 2016

Innovative approach but low yields

Summary:

This article describes a method for cyclic olefin polymerization employing a non-chelated monodentate benzimidazole Ni(II) complex. The specific reaction catalysed, is the vinyl polymerization of norbornene. The article also describes the methods...

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Sulfonated Schiff base dinuclear and polymeric copper( ii ) complexes: crystal structures, magnetic properties and catalytic application in Henry reaction


24 Dec 2016

More aldehydes need to be tested for reproducibility

Summary:

This paper describes the synthesis of dinuclear and polymeric copper complexes of a sulfonated Schiff base ligand, 2-(2-pyridylmethyleneamino)benzenesulfonic acid. Also described, are the crystal structures, magnetic properties and catalytic...

(1)

Theoretical study of borazine and substituted borazines using density functional theory method


23 Dec 2016

Good theory. Experimental data can add value.

Summary:

This paper describes the theoretical study on borazine and substituted borazines by the means of density functional theory. Amino group was used as the common donor group while four acceptor groups namely –NO2, –C≡N, –COCl and –NMe2 were chosen...

(0)

Reusable fluorescent photocrosslinked polymeric sensor for determining lead ions in aqueous media


22 Dec 2016

Excellent method. Minor adjustment will make it even better

Summary:

A polymeric film as fluorescent sensor for detection of Pb2+ in aqueous solutions, synthesised from 1-vinylimidazole, poly(ethylene glycol) diacrylate and trimethylolpropane triacrylate has been described. The manuscript also describes the...

(0)

Synthesis, characterization and DFT study of oxorhenium(v) complexes incorporating quinoline based tridentate ligands


22 Dec 2016

Good work, the basis set choice can be better

Summary:

The article presents the synthesis and characterization of two mononuclear Re(V) complexes. DFT and TD-DFT methods were employed for exploring the electronic structure and absorption spectra. Furthermore, the complexes were also tested for...

(0)

Rapid determination of trace level copper in tea infusion samples by solid contact ion selective electrode


22 Dec 2016

Should include Mn & Al data for clarity

Summary:

A new copper selective solid-state electrode based on o-xylylenebis(N,N-diisobutyldithiocarbamate) ionophore has been described. It has been developed for selectively measuring the copper levels found in the tea infusion samples. Robust, cheap...

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Tetraalkylammonium salts in heck-type reactions using an alkali metal hydrogen carbonate or an alkali metal acetate as the base


19 Dec 2016

Seminal paper for phase-transfer Heck-Mizoroki cross coupling

A pinacle reaction of the synthesis required the cross coupling off a two highly heteroatom functionalised fragments, the use of traditional Heck conditions, such as palladium (II) acetate, triphenyl phosphine and triethylamine afforded poor yields and...

(2)

Stereocontrolled construction of the trans-tetrahydrofuran units in Annonaceous acetogenins


19 Dec 2016

Experimental not reproducible as written

Procedure for synthesis of intermediate 2 was repeated three times at identical scale and reaction conditions as described and then modified. When followed exact same procedure as-written (12 hours), desired compound was obtained in 14% yield (confirmed by...

(3)

Stereoselective Synthesis of 3-Hydroxyproline Benzyl Esters fromN-Protected β-Aminoaldehydes and Benzyl Diazoacetate


19 Dec 2016

Adaptations Necessary to Improve Published Syntheses

This review addresses the published preparation of compound 10c as listed in JOC 69, 4361 (2004).  The stated preparation utilizes the inexpensive, commercially available diol, 6c.  The preparation begins by combining the diol with one equivalent of TESCl in...

(2)

O-(diphenylphosphinyl)hydroxylamine: preparation and some characteristic chemical reactions


19 Dec 2016

Adequate Synthesis; Improved Preparation Has Been Reported

This reaction was repeated to prepare O-diphenylphosphinyl hydroxylamine as this compound was reported to be a "less explosive" electrophilic aminating agent.  Note:  a recent improved preparation has been reported.  (DSC measurements of the isolated compound...

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Structural and conformational studies of 2-phenyl-1,3,2-diaza- and -dioxaboracycloalkanes


19 Dec 2016

Experimental Details

t-Bu amine (50 mmol) and methyl acrylate (50 mmol) were dissolved in MeOH (10 mL) and stirred overnight under nitrogen.  The secondary amine was isolated by Kugelrohr distillation after the MeOH had been removed by rotary evaporation.  The purified material...

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