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Highly Chemoselective Reduction of Amides (Primary, Secondary, Tertiary) to Alcohols using SmI2/Amine/H2O under Mild Conditions


18 Feb 2017

Good but some limitations

 

Description of Study

Szostak and coworkers reported highly chemoselective reduction of amides ( primary, secondary, Tertiary) to alcohols using SmI2  /Amine /H2O under mild conditions.  They  reduced amide to alcohol by stirring amide (0.1mmol) with...

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SYNTHESIS AND CHARACTERIZATION OF EFFICIENT TWO-PHOTON ABSORPTION CHROMOPHORES WITH INCREASED DIMENSIONALITY


18 Feb 2017

Sub grignard for n-BuLi for nmr clean product

Spirobifluorene: Synthesized spirobifluorene following the reported procedure (page 324-325) using  2-iodobiphenyl as starting material. It was difficult to isolate nmr-clean product and the yield was low, although they reported very high yield. Instead of...

(3)

Catalytic Enantioselective Friedel-Crafts Alkylation of Indoles with Nitroalkenes by Using a Simple Thiourea Organocatalyst


17 Feb 2017

Good reported synthesis with room for improvement

Review:

This article describes the structure optimization and initial mechanistic understanding of a simple thiourea catalyst for the enantioselective alkylation of indoles with nitroalkenes.  The indole ring has proven to be a “privileged” structure in...

(2)

New Well-Defined Poly(2,7-fluorene) Derivatives:  Photoluminescence and Base Doping


17 Feb 2017

Robust synthesis of difuctional fluorene derivatives

Synthesized compounds 1, 2 and 8. These reactions were successfully reproduced at large scales (up to 10 times). 

  1. Synthesis of compound 1: Maintaining the reaction temperature at -78 oC is critical for achiving disubstitution. The crude materials...

(2)

Bithiophene-Imide-Based Polymeric Semiconductors for Field-Effect Transistors: Synthesis, Structure−Property Correlations, Charge Carrier Polarity, and Device Stability


17 Feb 2017

Reliable Experimental

Synthesized 4,4’-didodecyl-2,2’-bithiophene (2b), and a similar compound 4,4’-dihexyl-2,2’-bithiophene (dhexbTH) following the procedure for the synthesis of 2a and 2b (given in supporting info.).

The yield for the synthesis of pure 2b was 50 %, which is...

(2)

Design of Narrow-Bandgap Polymers. Syntheses and Properties of Monomers and Polymers Containing Aromatic-Donor and o -Quinoid-Acceptor Units


17 Feb 2017

Better yields with slight optimizations

This paper describes the synthesis and characterization of a series of thiophene- and N-methylpyrrole-based low band gap polymers incorporating o-quinoid acceptors such as thienopyrazine, quinoxaline, benzothiadiazole, pyrazinoquinoxaline,...

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PtCl 2 -Catalyzed Rearrangement of Methylenecyclopropanes


17 Feb 2017

Good for Aldehydes, Modification for Ketone Substrates

This communication by Furstner and co-worker reported a novel rearrangement of methylenecyclopropanes 3 for the construction of variously substituted cyclobutenes and derivatives.

I am particularly interested in the preparation of cyclopropylidene bearing...

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Fluorescence Studies of Poly(p-phenyleneethynylene)s: The Effect of Anthracene Substitution


16 Feb 2017

Reproducible Synthesis

Swager et al reported the synthesis and fluorescence studies of poly(p-phenyleneethynylene)s. The experimental section, they made 4 different alkoxybenzenes using p-hydroquinone. I used this paper as a reference to synthesis a series of molecules:...

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High Current, Low Voltage Carbon Nanotube Enabled Vertical Organic Field Effect Transistors


16 Feb 2017

CN enabled VOFET potential to drive pixels in AMLED

In this manuscipt, a high current low voltage carbon nanotube (CN) enabled vertical organic field-effect transistor (VOFET) is reported that have the future potential to drive the pixels in active matrix organic light emitting diode (AMLED).

...

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Regioselective Copper-Catalyzed Amination of Chlorobenzoic Acids:  Synthesis and Solid-State Structures ofN-Aryl Anthranilic Acid Derivatives


08 Feb 2017

Synthesis of N-(4-carboxyphenyl) anthranilic acid

N-(4-carboxyphenyl) anthranilic acid (compound 31)

A mixture of 2-chlorobenzoic acid (1 mmol), 4-aminobenzoic acid (1 mmol), K2CO3 (2 mmol), Cu powder (0.009 mmol), and Cu2O (0.009 mmol) in 0.3 mL of 2-ethoxyethanol was refluxed at 130°C under inert...

(1)

Total Synthesis of Spirobacillene A


08 Feb 2017

Replicable (w/ Minor Modifications)

This paper was about first total synthesis of an indole alkaloid, Spirobacillene A and the key step of this approach was a Lewis acid catalyzed spirocyclization of an anisole derivative onto a tethered ynone.

I tried to replicate some of these reactions...

(2)

Particle size dependence of oxygen evolution reaction on nanocrystalline RuO2 and Ru0.8Co0.2O2−x


05 Feb 2017

A nice approach to synthesis of doped RuO2 nanopowders

Ruthenium oxide is one of the most active electrocatalytic material for oxygen evolution reaction (OER) and chlorine evolution reaction (CER). The attempts of improve its performance or to decrease the cost of the industrial electrodes resulted in many...

(2)

Synthesis and Luminescence Properties of Colloidal YVO4:Eu Phosphors


05 Feb 2017

Synthesis useful for a laboratory course.

Solid state phosphors in the form of nanosized particles attract a lot of attention. This interest is of both fundamental and practical character. Ultrafine and homogeneous fluorescence particles can be used as biological labels and in the various lightning...

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Synthesis of Thiazolinone, Aminopyrazole, Pyrazolopyrimidine, and Pyrazolotriazine Derivatives Starting from 1-Naphthyl-2-Cyanoacetamide


31 Jan 2017

Good yields, but greener solvents recommended

Summary:

This paper reports 1-Naphthyl-2-cyanoacetamide used as a precursor for the synthesis of different novel heterocyclic moieties such as 5-Aminopyrazole, thiazolinone, pyrazolo[1,5-a]pyrimidine, 4H-pyrazolo[3,4-d]pyrimidin-4-one and pyrazolo[3,4-d...

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Thermochemistry of halogen-containing organic compounds with influence on atmospheric chemistry


31 Jan 2017

Good study - need to find methods for iodinated-molecules

Summary:

This research article reports a study on the thermocehemical behaviour of halogen-containing molecules in atmospheric chemical processes. The thermodynamic and thermochemical model of these components helps in understanding the interactions in...

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Synthesis and in Vitro Anti-Tumor Activity of A New Class of Acyclic Thioglycosides


31 Jan 2017

Innovative approach - Lower yields

Summary:

This paper reports the synthesis of a new class of acrylamide thioglycoside derivatives utilizing a one-pot synthesis. Further heating of the resultant glycosides with hydrazine is reported to give pyrazole derivatives. Among those synthesized,...

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Preparation and characterization of uniform, spherical particles of Y2O2S and Y2O2S:Eu


29 Jan 2017

Neat but a bit complicated synthesis

Yttrium oxysulfide – Y2O2S is knows an excellent host material for the Eu(III) activated red emission phosphor, which has been used for decades in the CRT displays and conventional TV due to its excellent brightness, color purity, life time and compatibility...

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Synthesis and Azidolysis of 2-Chlorotetramethylguanidine. Synthetic Utility of Hexa- and Tetramethylguanidinium Azide


14 Jan 2017

Good synthesis but experimental lacking some useful details

 

The preparation of tetramethylguanidium azide was successfully carried out following the literature preparation (JOC 31, 1426 (1966)).  Hydrazoic acid was prepared as a Et2O solution by adding conc HCl over 30 minutes to a ice cold solution of NaN3 in...

(1)

A fast and oxygen-promoted protocol for the ligand-free Suzuki reaction of 2-halogenated pyridines in aqueous media


08 Jan 2017

Best method to make various 2-phenylpyridine derivatives

Review :-

1) Synthesized all compounds from Table 1 (1-8) and Table 2 (1-13). I was able to achieve higher yields than the ones reported in this paper by doubling the catalyst concentration.

2) I used excess i.e 3 mol % Palladium acetate than the...

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1-Naphthyl-2-cyanoacetamide in heterocyclic synthesis: synthesis and evaluation of the antimicrobial activity of some new pyridine, pyrimidine, and naphtho[2,1-b]oxazine derivatives


01 Jan 2017

Very well reproducible but greener solvents need to be used

Summary:

This paper reports the reactivity of the methylene group of 1-naphthyl-2-cyanoacetamide 1 which was tested towards different reagents. These new compounds have been reported to be characterized by elemental analysis, IR, 1HNMR, 13C NMR, and mass...

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