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Ir-Catalyzed Direct Borylation at the 4-Position of Pyrene


22 Feb 2017

Useful experimental

1. Synthesized compound 1 and another similar compound using the procedure described in this article.

2. Used 0.2 mmol Iridium instead of 0.1 mmol as reported. The reaction was monitored by TLC and after 48 hrs, all starting materials was consumed. The...

(3)

A Practical Synthesis of 3,3‐Difluorocyclobutane Carboxylic Acid


22 Feb 2017

Steven P. Cummings, Post-Doc

This communication was outstanding in providing a vast improvement to a very dangerous and potentially synthetically challenging method in obtaining 3,3-difluorocyclobutane carboxylic acid.  Ultimately the synthesis provided greater yields, easier workups,...

(3)

Bile Acid-Based 1,2,4-Trioxanes: Synthesis and Antimalarial Assessment(1)


19 Feb 2017

Decarboxylative oxidation of lithocholic acid

Summary:

A new series of bile acid-based trioxanes have been synthesized and assessed for their antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route.

The Reaction of Interest:

Decarboxylative oxidation of...

(2)

Eco-friendly synthesis of 2-substituted benzothiazoles catalyzed by cetyltrimethyl ammonium bromide (CTAB) in water


18 Feb 2017

Innovative but has errors which affects reproducibility

Summary:

This paper reports a CTAB-catalyzed method developed for the synthesis of 2-substituted benzothiazoles by the condensation of 2-aminothiophenol with aldehydes (RCHO: R = Alkyl, Aryl, Heteroaryl, 2-Arylformyl). Use of cetyltrimethyl ammonium...

(0)

A density functional study of oxorhenium(V) complexes incorporating quinoline or isoquinoline carboxylic acids: structural, spectroscopic, and electronic properties


18 Feb 2017

Using Stuttgart basis set improves reproducibility

Summary:

This paper describes the density functional theoretical study on oxorhenium(V) complexes incorporating quinoline or isoquinoline carboxylic acids. The study is aimed at understanding causes for the difference in stabilities of particular isomers...

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A novel Schiff-base as a Cu(II) ion fluorescent sensor in aqueous solution


18 Feb 2017

The role of DMSO in the system needs to be investigated

Summary:

This paper reports the synthesis of a Schiff base ligand (L) by reaction of 5,5’-methylene-bis-salicylaldehyde with amidol (2,4-diaminophenol). The applicability of this ligand as a new fluorescent Cu(II) sensor in aqueous medium was assessed. A...

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An efficient method for the preparation of N,N-disubstituted 1,2-diamines


18 Feb 2017

Good synthesis with comments for improvement

The article presents a synthetic methodology to prepare chiral N,N-disubstituted, 1,2-diamines, which can be convenient precursors to tridentate ligands.

Particularly, I used the synthetic route using cyclohexane-1,2-diamine (both racemic and enatiopure)...

(3)

Preparation of thermally stable and soluble mesitylcopper(I) and its application in organic synthesis


18 Feb 2017

Synthesis of mesitylcopper

Synthesized mesitylcopper by following the procedure. 

(1) High quality anhydrous solvents (THF/dioxane/Toluene) and good argon or nitrogen protection for all the operations are key to get high yield and quality product, since the mesitylcoppor solution is...

(3)

Highly Chemoselective Reduction of Amides (Primary, Secondary, Tertiary) to Alcohols using SmI2/Amine/H2O under Mild Conditions


18 Feb 2017

Good but some limitations

 

Description of Study

Szostak and coworkers reported highly chemoselective reduction of amides ( primary, secondary, Tertiary) to alcohols using SmI2  /Amine /H2O under mild conditions.  They  reduced amide to alcohol by stirring amide (0.1mmol) with...

(3)

SYNTHESIS AND CHARACTERIZATION OF EFFICIENT TWO-PHOTON ABSORPTION CHROMOPHORES WITH INCREASED DIMENSIONALITY


18 Feb 2017

Sub grignard for n-BuLi for nmr clean product

Spirobifluorene: Synthesized spirobifluorene following the reported procedure (page 324-325) using  2-iodobiphenyl as starting material. It was difficult to isolate nmr-clean product and the yield was low, although they reported very high yield. Instead of...

(3)

Catalytic Enantioselective Friedel-Crafts Alkylation of Indoles with Nitroalkenes by Using a Simple Thiourea Organocatalyst


17 Feb 2017

Good reported synthesis with room for improvement

Review:

This article describes the structure optimization and initial mechanistic understanding of a simple thiourea catalyst for the enantioselective alkylation of indoles with nitroalkenes.  The indole ring has proven to be a “privileged” structure in...

(2)

New Well-Defined Poly(2,7-fluorene) Derivatives:  Photoluminescence and Base Doping


17 Feb 2017

Robust synthesis of difuctional fluorene derivatives

Synthesized compounds 1, 2 and 8. These reactions were successfully reproduced at large scales (up to 10 times). 

  1. Synthesis of compound 1: Maintaining the reaction temperature at -78 oC is critical for achiving disubstitution. The crude materials...

(2)

Bithiophene-Imide-Based Polymeric Semiconductors for Field-Effect Transistors: Synthesis, Structure−Property Correlations, Charge Carrier Polarity, and Device Stability


17 Feb 2017

Reliable Experimental

Synthesized 4,4’-didodecyl-2,2’-bithiophene (2b), and a similar compound 4,4’-dihexyl-2,2’-bithiophene (dhexbTH) following the procedure for the synthesis of 2a and 2b (given in supporting info.).

The yield for the synthesis of pure 2b was 50 %, which is...

(2)

Design of Narrow-Bandgap Polymers. Syntheses and Properties of Monomers and Polymers Containing Aromatic-Donor and o -Quinoid-Acceptor Units


17 Feb 2017

Better yields with slight optimizations

This paper describes the synthesis and characterization of a series of thiophene- and N-methylpyrrole-based low band gap polymers incorporating o-quinoid acceptors such as thienopyrazine, quinoxaline, benzothiadiazole, pyrazinoquinoxaline,...

(2)

PtCl 2 -Catalyzed Rearrangement of Methylenecyclopropanes


17 Feb 2017

Good for Aldehydes, Modification for Ketone Substrates

This communication by Furstner and co-worker reported a novel rearrangement of methylenecyclopropanes 3 for the construction of variously substituted cyclobutenes and derivatives.

I am particularly interested in the preparation of cyclopropylidene bearing...

(3)

Fluorescence Studies of Poly(p-phenyleneethynylene)s: The Effect of Anthracene Substitution


16 Feb 2017

Reproducible Synthesis

Swager et al reported the synthesis and fluorescence studies of poly(p-phenyleneethynylene)s. The experimental section, they made 4 different alkoxybenzenes using p-hydroquinone. I used this paper as a reference to synthesis a series of molecules:...

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High Current, Low Voltage Carbon Nanotube Enabled Vertical Organic Field Effect Transistors


16 Feb 2017

CN enabled VOFET potential to drive pixels in AMLED

In this manuscipt, a high current low voltage carbon nanotube (CN) enabled vertical organic field-effect transistor (VOFET) is reported that have the future potential to drive the pixels in active matrix organic light emitting diode (AMLED).

...

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Regioselective Copper-Catalyzed Amination of Chlorobenzoic Acids:  Synthesis and Solid-State Structures ofN-Aryl Anthranilic Acid Derivatives


08 Feb 2017

Synthesis of N-(4-carboxyphenyl) anthranilic acid

N-(4-carboxyphenyl) anthranilic acid (compound 31)

A mixture of 2-chlorobenzoic acid (1 mmol), 4-aminobenzoic acid (1 mmol), K2CO3 (2 mmol), Cu powder (0.009 mmol), and Cu2O (0.009 mmol) in 0.3 mL of 2-ethoxyethanol was refluxed at 130°C under inert...

(1)

Total Synthesis of Spirobacillene A


08 Feb 2017

Replicable (w/ Minor Modifications)

This paper was about first total synthesis of an indole alkaloid, Spirobacillene A and the key step of this approach was a Lewis acid catalyzed spirocyclization of an anisole derivative onto a tethered ynone.

I tried to replicate some of these reactions...

(1)

Particle size dependence of oxygen evolution reaction on nanocrystalline RuO2 and Ru0.8Co0.2O2−x


05 Feb 2017

A nice approach to synthesis of doped RuO2 nanopowders

Ruthenium oxide is one of the most active electrocatalytic material for oxygen evolution reaction (OER) and chlorine evolution reaction (CER). The attempts of improve its performance or to decrease the cost of the industrial electrodes resulted in many...

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