Summary:
Synthesis of various silacycles has been reported.
The Reaction of Interest:
Synthesis of t-BuSiHCl2 (18.5%, 50 mmol) via reaction of HSiCl3 (2 equiv) with t-BuLi.
Practical Observations:
1. Synthesized compound 1 and another similar compound using the procedure described in this article.
2. Used 0.2 mmol Iridium instead of 0.1 mmol as reported. The reaction was monitored by TLC and after 48 hrs, all starting materials was consumed. The...
This communication was outstanding in providing a vast improvement to a very dangerous and potentially synthetically challenging method in obtaining 3,3-difluorocyclobutane carboxylic acid. Ultimately the synthesis provided greater yields, easier workups,...
Summary:
A new series of bile acid-based trioxanes have been synthesized and assessed for their antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route.
The Reaction of Interest:
Decarboxylative oxidation of...
Summary:
This paper reports a CTAB-catalyzed method developed for the synthesis of 2-substituted benzothiazoles by the condensation of 2-aminothiophenol with aldehydes (RCHO: R = Alkyl, Aryl, Heteroaryl, 2-Arylformyl). Use of cetyltrimethyl ammonium...
Summary:
This paper describes the density functional theoretical study on oxorhenium(V) complexes incorporating quinoline or isoquinoline carboxylic acids. The study is aimed at understanding causes for the difference in stabilities of particular isomers...
Summary:
This paper reports the synthesis of a Schiff base ligand (L) by reaction of 5,5’-methylene-bis-salicylaldehyde with amidol (2,4-diaminophenol). The applicability of this ligand as a new fluorescent Cu(II) sensor in aqueous medium was assessed. A...
The article presents a synthetic methodology to prepare chiral N,N-disubstituted, 1,2-diamines, which can be convenient precursors to tridentate ligands.
Particularly, I used the synthetic route using cyclohexane-1,2-diamine (both racemic and enatiopure)...
Synthesized mesitylcopper by following the procedure.
(1) High quality anhydrous solvents (THF/dioxane/Toluene) and good argon or nitrogen protection for all the operations are key to get high yield and quality product, since the mesitylcoppor solution is...
Description of Study
Szostak and coworkers reported highly chemoselective reduction of amides ( primary, secondary, Tertiary) to alcohols using SmI2 /Amine /H2O under mild conditions. They reduced amide to alcohol by stirring amide (0.1mmol) with...
Spirobifluorene: Synthesized spirobifluorene following the reported procedure (page 324-325) using 2-iodobiphenyl as starting material. It was difficult to isolate nmr-clean product and the yield was low, although they reported very high yield. Instead of...
Review:
This article describes the structure optimization and initial mechanistic understanding of a simple thiourea catalyst for the enantioselective alkylation of indoles with nitroalkenes. The indole ring has proven to be a “privileged” structure in...
Synthesized compounds 1, 2 and 8. These reactions were successfully reproduced at large scales (up to 10 times).
Synthesized 4,4’-didodecyl-2,2’-bithiophene (2b), and a similar compound 4,4’-dihexyl-2,2’-bithiophene (dhexbTH) following the procedure for the synthesis of 2a and 2b (given in supporting info.).
The yield for the synthesis of pure 2b was 50 %, which is...
This paper describes the synthesis and characterization of a series of thiophene- and N-methylpyrrole-based low band gap polymers incorporating o-quinoid acceptors such as thienopyrazine, quinoxaline, benzothiadiazole, pyrazinoquinoxaline,...
This communication by Furstner and co-worker reported a novel rearrangement of methylenecyclopropanes 3 for the construction of variously substituted cyclobutenes and derivatives.
I am particularly interested in the preparation of cyclopropylidene bearing...
Swager et al reported the synthesis and fluorescence studies of poly(p-phenyleneethynylene)s. The experimental section, they made 4 different alkoxybenzenes using p-hydroquinone. I used this paper as a reference to synthesis a series of molecules:...
In this manuscipt, a high current low voltage carbon nanotube (CN) enabled vertical organic field-effect transistor (VOFET) is reported that have the future potential to drive the pixels in active matrix organic light emitting diode (AMLED).
...
N-(4-carboxyphenyl) anthranilic acid (compound 31)
A mixture of 2-chlorobenzoic acid (1 mmol), 4-aminobenzoic acid (1 mmol), K2CO3 (2 mmol), Cu powder (0.009 mmol), and Cu2O (0.009 mmol) in 0.3 mL of 2-ethoxyethanol was refluxed at 130°C under inert...
This paper was about first total synthesis of an indole alkaloid, Spirobacillene A and the key step of this approach was a Lewis acid catalyzed spirocyclization of an anisole derivative onto a tethered ynone.
I tried to replicate some of these reactions...