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- To add a review, simply search for your paper.
- DOI is best but the full title also usually works.
- When you find it, click on the Add a Review link as shown below.
As the claim of a metal-free cross-coupling is quite sensational, the authors were fairly rigorous in their characterization of reagents and QC. However, since publication numerous questions have arisen as to possible alternate cross-coupling mechanisms,...
This paper describes the development and use of a CRISPR based diagnostic for Mycobacterium tuberculosis (Mtb). I was particularly interested in this paper because it hits all the things which my research is focused on – Mtb, diagnostics, and the practical...
I came across this article by Hutto et al. while investigating the effects of mutant rdgB gene within the PITP domain of the Drosophila genome. The rdgB protein is responsible for Ca2+ storage for use in the phototransduction cascade; however our data showed...
The premise of the article is to summarize the ways in which stimuli- responsive polymersomes are involved in the creation of nanocarriers, as well as their contribution to each nanocarrier's performance in varied environments or stimuli. Polymersomes are...
Summary
Researchers discovered a protein which triggers satellite cells to proliferate and heal. In fish with severe muscle damage, injection of NAMPT led to the regeneration of muscle and the return of normal movement. This study demonstrates that NAMPT,...
Summary:
This paper describes a novel way to measure core body temperature using a three-dimensional (3D) printed wearable “earable” smart device. The device is designed to be worn on the ear and track core body temperature from the tympanic membrane (i.e.,...
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A framework for improving knee rehabilitation and reducing ACL injury incidence and reinjury rates post anterior cruciate ligament reconstruction has been described. The framework encourages a global approach, whereby ‘proximal’ is not confined to...
This classic review outlines several therapeutic uses of carbon monoxide (CO). The overall language of the report is very easy to understand and read while presenting in-depth descriptions and examples when needed. This review touches on the primary pathways...
Regulatory review on status of FDA understanding of drug transporters. Suggest policies and guidance to direct the industry to advance drug development
Great paper highlighting the PK of propranolol. Went into ADME properties and expanding indications
Response letter from reader suggesting their is now clinical evidence for salicylates casuing GI mucosa erosion and eventual bleeding.
The concept of citation network analysis is not new, but it is important. In this manuscript, Dr. Leng uses Web of Science to analyze a subfield of papers about radomized controlled trials (RCTs) of coronay heart disease between 1965-1984. While this topic...
Toomey and colleagues report the results of a survey of 14 early career researchers (ECRs) about "open science". On a whole, these ECRs view open science positively, but hold reservations about the impact adopting open science practices might have on their...
A detailed observational study of the trends in biological sciences publishing, including analysis of time-to-publication, time-to-graduation, and the increasing minimum publication unit. The paper is interwoven with thoughtful analysis and perspective from...
This paper by Erlanson and colleagues describes the disulfide tethering technique, which has proven to be a reproducible and versatile method for finding fragment hits. The main advance is the covalent targeting of the fragment library to a specific site on a...
This paper was very helpful in my thesis research. I had some difficulties reproducing the cyclic voltammetry results in the beginning, which I later attributed to the surface of my electrode. Once I changed my polishing technique, I was able to reproduce...
I followed this paper based on a need to synthesize their reported 7a as a substrate for a synthesis. I thought this method would be better than the previous Zinc-mediated cross-coupling approach. We found that the published procedure worked very well...