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A Practical Synthesis of Rosuvastatin and Other Statin Intermediates


22 Mar 2017

Good synthesis method

Summary:

This paper reports an efficient method for aldol condensation between a methyl 3-hydroxy-5-oxohexanoate derivative and a pyrimidine carbaldehyde comprising the core structure of rosuvastatin. The authors have described the method as an...

(1)

A Green Route for the One-Pot Synthesis of 1,2-Disubstituted Benzimidazoles Using Iron(III) Phosphate under Solventless Conditions


12 Mar 2017

Easy process to reproduce

Summary:

A simple, convenient, and environment-friendly method for synthesis of 1,2-disubstituted benzimidazoles in high yields under extremely mild conditions, has been described. The methodology described, involves condensation of o-phenylenediamine...

(1)

Rapid and Green Synthesis of some Benzothiazole-, Benzimidazole- and Benzoxazole-2-thiol Derivatives Using Copper Sulfate in Aqueous Media


09 Mar 2017

Reproducible method. Certain aspects can be improved.

Summary:

An easy, green, efficient and simple for synthesis of derivatives of benzimidazole-, benzothiazole- and benzoxazole-2-thiol has been described. Although previous methods are available in literature for synthesis of such compounds, this method...

(1)

Kinetic study of the complex reaction between copper(II) and 2-(2′-hydroxy-3′-methoxyphenyl)benzothiazole


09 Mar 2017

Kinetic study works well. Ligand synthesis can be improved.

Summary:

This paper reports an interesting property of the O, N and S donor ligand 2-(2’-Hydroxy-3’-methoxyphenyl)benzothiazole which makes it switch chelating donor sites from O, S (at pH < 5.0) to O, N (above pH 5.0) while reacting with Cu(II) acetate...

(0)

Structure–mechanical property correlations of model siloxane elastomers with controlled network topology


23 Feb 2017

Incredible Depth of Data

This paper does a thorough analysis of structure and property relationships. The analyiss is thorougouh and well backed up by data. I found the secion on deswollen materials particularly helpful and interesting. 

(2)

Macroporous silicone biomaterials with modified surface chemistry: Production and characterization


23 Feb 2017

Innovative Technique to Create a Membrane

Well written paper. The technique of using a removabile filler to direct pore size in a membrane is an innovative method and should be studied more. 

(1)

Elastomeric Networks with Bimodal Chain-Length Distributions


23 Feb 2017

Strong Fundamental Polymer Structure Information

The data in this paper is veryw ell laid out. The data is easily reproducable and the work is easy to follow. 

(1)

Comparative Study of Different Cross-Linking Agents for the Immobilization of Functionalized Carbon Nanotubes within a Chitosan Film Supported on a Graphite−Epoxy Composite Electrode


23 Feb 2017

very versatile procedure

Covalent attachment of small organometallic molecules to COOH-MWCNTs was successfully achieved using the described methods of EDC/NHS coupling. A qualitative yield was achieved which allowed for a unique route to create redox active MWCNTs. After exploration...

(4)

N,N‘-Ditosylhydrazine:  A Convenient Reagent for Facile Synthesis of Diazoacetates†


23 Feb 2017

Reproducible, but Yields Lower Than Described

Summary:

An efficient method for the synthesis of diazoacetates from the coresponding bromoacetates and N,N'-ditosylhydrazine has been described. In fact, diazoacetates can be prepared from various alcohols by acylation with bromoacetyl bromide, followed by...

(7)

Regioselective synthesis of substituted rubrenes


22 Feb 2017

Excellent method to generate rubrenes

The manuscript entitled “Regioselective Synthesis of Substituted Rubrenes” is nicely written and excellent piece of work. Manuscript describes a method to generate Rubrene derivatives using a Diels Alder reaction and Phenyl lithium addition as key steps....

(1)

Synthesis of the Selective D 2 Receptor Agonist PNU-95666E from d -Phenylalanine Using a Sequential Oxidative Cyclization Strategy


22 Feb 2017

Good synthesis of enantiomerically pure (R)-sumanirole

PNU-95666E (sumanirole) was reported to be a highly selective D2 receptor full agonist. It was originally developed for the treatment of Parkinson’s disease. An eight steps synthesis was developed for the scale up of enantiomerically pure (R)-sumanirole with...

(1)

Silacyclohexadienylanionen bis- und tris-trimethylsilyl)-silacyclohexadiene


22 Feb 2017

Reproducible Reaction

Summary:

Synthesis of various silacycles has been reported. 

The Reaction of Interest:

Synthesis of t-BuSiHCl2 (18.5%, 50 mmol) via reaction of HSiCl3 (2 equiv) with t-BuLi.

Practical Observations:

  •  The reaction is reproducible, however 2 equiv...

(2)

Ir-Catalyzed Direct Borylation at the 4-Position of Pyrene


22 Feb 2017

Useful experimental

1. Synthesized compound 1 and another similar compound using the procedure described in this article.

2. Used 0.2 mmol Iridium instead of 0.1 mmol as reported. The reaction was monitored by TLC and after 48 hrs, all starting materials was consumed. The...

(3)

A Practical Synthesis of 3,3‐Difluorocyclobutane Carboxylic Acid


22 Feb 2017

Steven P. Cummings, Post-Doc

This communication was outstanding in providing a vast improvement to a very dangerous and potentially synthetically challenging method in obtaining 3,3-difluorocyclobutane carboxylic acid.  Ultimately the synthesis provided greater yields, easier workups,...

(3)

Bile Acid-Based 1,2,4-Trioxanes: Synthesis and Antimalarial Assessment(1)


19 Feb 2017

Decarboxylative oxidation of lithocholic acid

Summary:

A new series of bile acid-based trioxanes have been synthesized and assessed for their antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route.

The Reaction of Interest:

Decarboxylative oxidation of...

(2)

Eco-friendly synthesis of 2-substituted benzothiazoles catalyzed by cetyltrimethyl ammonium bromide (CTAB) in water


18 Feb 2017

Innovative but has errors which affects reproducibility

Summary:

This paper reports a CTAB-catalyzed method developed for the synthesis of 2-substituted benzothiazoles by the condensation of 2-aminothiophenol with aldehydes (RCHO: R = Alkyl, Aryl, Heteroaryl, 2-Arylformyl). Use of cetyltrimethyl ammonium...

(0)

A density functional study of oxorhenium(V) complexes incorporating quinoline or isoquinoline carboxylic acids: structural, spectroscopic, and electronic properties


18 Feb 2017

Using Stuttgart basis set improves reproducibility

Summary:

This paper describes the density functional theoretical study on oxorhenium(V) complexes incorporating quinoline or isoquinoline carboxylic acids. The study is aimed at understanding causes for the difference in stabilities of particular isomers...

(0)

A novel Schiff-base as a Cu(II) ion fluorescent sensor in aqueous solution


18 Feb 2017

The role of DMSO in the system needs to be investigated

Summary:

This paper reports the synthesis of a Schiff base ligand (L) by reaction of 5,5’-methylene-bis-salicylaldehyde with amidol (2,4-diaminophenol). The applicability of this ligand as a new fluorescent Cu(II) sensor in aqueous medium was assessed. A...

(3)

An efficient method for the preparation of N,N-disubstituted 1,2-diamines


18 Feb 2017

Good synthesis with comments for improvement

The article presents a synthetic methodology to prepare chiral N,N-disubstituted, 1,2-diamines, which can be convenient precursors to tridentate ligands.

Particularly, I used the synthetic route using cyclohexane-1,2-diamine (both racemic and enatiopure)...

(4)

Preparation of thermally stable and soluble mesitylcopper(I) and its application in organic synthesis


18 Feb 2017

Synthesis of mesitylcopper

Synthesized mesitylcopper by following the procedure. 

(1) High quality anhydrous solvents (THF/dioxane/Toluene) and good argon or nitrogen protection for all the operations are key to get high yield and quality product, since the mesitylcoppor solution is...

(3)