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07 Apr 2021

Bioimaging Carbon Dots track and target liver cancer cells

Cancer dots can be used to generate bioimages of drug delivery systems in action. Their purpose is to function as a selective drug delivery system to target cancer cells, HepG2 cells, as well as trace and potentially kill the cancer cell. Fluorescent carbon...

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02 Apr 2021

Review of Various Methodologies Used to Create Nanoparticles

 This article serves as a review of different methods that can be used to create polymeric nanoparticles. It gives immense details about the basics of polymeric nanoparticles including what they are as well as their numerous polymeric reagents that are used...

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Successful Treatment of Vasovagal Syncope Due to Blood-Injury Phobia by Physical Maneuvering


31 Mar 2021

No magic cure!

This paper describes the use of various body positions in order to overcome vasovagal syncope. So, before I begin this review I need to give a bit of background as to why I have been reading this – esp. as I am a molecular microbiologist, not an MD, and...

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Conducting polymers for neural interfaces: Challenges in developing an effective long-term implant


26 Mar 2021

Polymers could replace metals in electrodes for prosthetics

 

Modifying electrodes, to include polymers instead of metals,  could be beneficial for progressions in making prosthetics. This particular hybrid of a study and a review, focuses on the possibilities of improving cochlear and bionic eye prosthetics. The...

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A New Short Synthesis of 3-Substituted 5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indoles (Amino-CBIs)


22 Mar 2021

Efficient and reproducible method to obtain Amino-CBIs

The presented route provides an efficient and highly reproducible method to obtain penultimate allyl-protected intermediates of 3-Substituted 5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indoles (amino-CBIs).  De-allylation utilizing Grubbs carbene proved...

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18 Mar 2021

pH Responsive Gold Nanocarriers Target Cancerous Cells

Gold nanocarriers are fused with a ph responsive and a hydrophobic polymers to form a system that will more readily detect as well as release drugs in enviroments that are inhabited by cancerous tumors. In the body, the cancerous tumors thrive in an...

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17 Mar 2021

Specinomycin restores susceptibly to resistant Mtb

Full disclosure – I know two of the authors of this paper professionally, however this has had no effect on my review of this work – but for the sake of transparency I thought I should mention this!

First impressions:

This publication has a very compelling...

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17 Mar 2021

Specinomycin restores susceptibly to resistant Mtb strains

Full disclosure – I know two of the authors of this paper professionally, however this has had no effect on my review (either good or bad) this work – but for the sake of transparency I thought I should mention this!

 

First impressions:

This publication...

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16 Mar 2021

Major concerns have been raised

As the claim of a metal-free cross-coupling is quite sensational, the authors were fairly rigorous in their characterization of reagents and QC. However, since publication numerous questions have arisen as to possible alternate cross-coupling mechanisms,...

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15 Mar 2021

CRISPR-based test for Mycobacterium tuberculosis

This paper describes the development and use of a CRISPR based diagnostic for Mycobacterium tuberculosis (Mtb). I was particularly interested in this paper because it hits all the things which my research is focused on – Mtb, diagnostics, and the practical...

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13 Mar 2021

Ca2+ MCU, Insight into Ca2+ Affect on Cone Apoptosis

I came across this article by Hutto et al. while investigating the effects of mutant rdgB gene within the PITP domain of the Drosophila genome. The rdgB protein is responsible for Ca2+ storage for use in the phototransduction cascade; however our data showed...

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Stimuli‐Responsive Polymersomes as Nanocarriers for Drug and Gene Delivery


11 Mar 2021

Polymersomes in nanocarriers and varied environments

   The premise of the article is to summarize the ways in which stimuli- responsive polymersomes are involved in the creation of nanocarriers, as well as their contribution to each nanocarrier's performance in varied environments or stimuli. Polymersomes are...

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01 Mar 2021

Promising Discovery in Satellite Cell Research

Summary

Researchers discovered a protein which triggers satellite cells to proliferate and heal. In fish with severe muscle damage, injection of NAMPT led to the regeneration of muscle and the return of normal movement. This study demonstrates that NAMPT,...

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26 Feb 2021

Review of 3D Printed “Earable” Smart Devices

Summary:

This paper describes a novel way to measure core body temperature using a three-dimensional (3D) printed wearable “earable” smart device. The device is designed to be worn on the ear and track core body temperature from the tympanic membrane (i.e.,...

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26 Feb 2021

Review of framework for improving knee rehabilitation

Summary:

A framework for improving knee rehabilitation and reducing ACL injury incidence and reinjury rates post anterior cruciate ligament reconstruction has been described. The framework encourages a global approach, whereby ‘proximal’ is not confined to...

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The therapeutic potential of carbon monoxide


25 Feb 2021

A "go-to" review on the therapeutic uses of carbon monoxide

This classic review outlines several therapeutic uses of carbon monoxide (CO). The overall language of the report is very easy to understand and read while presenting in-depth descriptions and examples when needed. This review touches on the primary pathways...

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Regulation of drug transporters


18 Feb 2021

Drug Transporters

Regulatory review on status of FDA understanding of drug transporters. Suggest policies and guidance to direct the industry to advance drug development

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Pharmacokinetics of propranolol.


18 Feb 2021

PK of a non-selective beta blocker

Great paper highlighting the PK of propranolol. Went into ADME properties and expanding indications

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Paractamol or Aspirin?


18 Feb 2021

1st Review

Response letter from reader suggesting their is now clinical evidence for salicylates casuing GI mucosa erosion and eventual bleeding.

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14 Feb 2021

Excellent Exposition of Citation Bias

The concept of citation network analysis is not new, but it is important. In this manuscript, Dr. Leng uses Web of Science to analyze a subfield of papers about radomized controlled trials (RCTs) of coronay heart disease between 1965-1984. While this topic...

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