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Effect of isocyanate content on thermal and mechanical properties of polyurea


(1)
04 May 2017

Influence of morphology on the mechanical properties of PU

The experimental section was adequately detailed in procedure and results describing necessary DMA and MDSC data were given.  No substantial differences were recorded while reproducing similar results.

Dynamic Properties of Polyurea


(0)
04 May 2017

Strain rate/ impact loading dependency of polyurea

This communication was outstanding in providing a comprehensive study of polyurea properties for: 

1) Development of constitutive model for polyurea at high strain rate loading conditions

2) Study of polyurea behavior from a quasi-static to ultra high...

A commercially available fluorescence chemosensor for copper ion and its application in bioimaging


(1)
30 Mar 2017

Cu(II) exclusively detectable. Cu(I) can't be stabilized.

Summary:

This paper reports the chemosensing properties of a commercially available fluorescent probe, 1,8-diamino naphthalene for copper ion detection in the aqueous medium and its application in bioimaging. The proposed mechanism involves fluorescence...

A convenient one-pot synthesis of 2-substituted benzimidazoles


(1)
23 Mar 2017

Good Synthesis procedure

Summary:

An efficient and green method for synthesis of 2 substituted benzimidazoles has been described. Despite previous methods being available in literature for synthesis of such compounds, the ease of operation, use of common and non-toxic solvent and...

Copper-Catalyzed Synthesis of Benzimidazoles via Cascade Reactions ofo-Haloacetanilide Derivatives with Amidine Hydrochlorides


(1)
22 Mar 2017

Slight adjustments will give more yields

Summary:

This paper reports an efficient method for synthesising benzimidazoles through cascade reactions of o-haloacetoanilide derivatives with amidine hydrochlorides. 10 mol % CuBr was used as the catalyst and Cs2CO3 as the base. The reactions were...

A Practical Synthesis of Rosuvastatin and Other Statin Intermediates


(1)
22 Mar 2017

Good synthesis method

Summary:

This paper reports an efficient method for aldol condensation between a methyl 3-hydroxy-5-oxohexanoate derivative and a pyrimidine carbaldehyde comprising the core structure of rosuvastatin. The authors have described the method as an...

A Green Route for the One-Pot Synthesis of 1,2-Disubstituted Benzimidazoles Using Iron(III) Phosphate under Solventless Conditions


(1)
12 Mar 2017

Easy process to reproduce

Summary:

A simple, convenient, and environment-friendly method for synthesis of 1,2-disubstituted benzimidazoles in high yields under extremely mild conditions, has been described. The methodology described, involves condensation of o-phenylenediamine...

Rapid and Green Synthesis of some Benzothiazole-, Benzimidazole- and Benzoxazole-2-thiol Derivatives Using Copper Sulfate in Aqueous Media


(1)
09 Mar 2017

Reproducible method. Certain aspects can be improved.

Summary:

An easy, green, efficient and simple for synthesis of derivatives of benzimidazole-, benzothiazole- and benzoxazole-2-thiol has been described. Although previous methods are available in literature for synthesis of such compounds, this method...

Kinetic study of the complex reaction between copper(II) and 2-(2′-hydroxy-3′-methoxyphenyl)benzothiazole


(0)
09 Mar 2017

Kinetic study works well. Ligand synthesis can be improved.

Summary:

This paper reports an interesting property of the O, N and S donor ligand 2-(2’-Hydroxy-3’-methoxyphenyl)benzothiazole which makes it switch chelating donor sites from O, S (at pH < 5.0) to O, N (above pH 5.0) while reacting with Cu(II) acetate...

Structure–mechanical property correlations of model siloxane elastomers with controlled network topology


(2)
23 Feb 2017

Incredible Depth of Data

This paper does a thorough analysis of structure and property relationships. The analyiss is thorougouh and well backed up by data. I found the secion on deswollen materials particularly helpful and interesting. 

Macroporous silicone biomaterials with modified surface chemistry: Production and characterization


(1)
23 Feb 2017

Innovative Technique to Create a Membrane

Well written paper. The technique of using a removabile filler to direct pore size in a membrane is an innovative method and should be studied more. 

Elastomeric Networks with Bimodal Chain-Length Distributions


(1)
23 Feb 2017

Strong Fundamental Polymer Structure Information

The data in this paper is veryw ell laid out. The data is easily reproducable and the work is easy to follow. 

Comparative Study of Different Cross-Linking Agents for the Immobilization of Functionalized Carbon Nanotubes within a Chitosan Film Supported on a Graphite−Epoxy Composite Electrode


(4)
23 Feb 2017

very versatile procedure

Covalent attachment of small organometallic molecules to COOH-MWCNTs was successfully achieved using the described methods of EDC/NHS coupling. A qualitative yield was achieved which allowed for a unique route to create redox active MWCNTs. After exploration...

N,N‘-Ditosylhydrazine:  A Convenient Reagent for Facile Synthesis of Diazoacetates†


(7)
23 Feb 2017

Reproducible, but Yields Lower Than Described

Summary:

An efficient method for the synthesis of diazoacetates from the coresponding bromoacetates and N,N'-ditosylhydrazine has been described. In fact, diazoacetates can be prepared from various alcohols by acylation with bromoacetyl bromide, followed by...

Regioselective synthesis of substituted rubrenes


(1)
22 Feb 2017

Excellent method to generate rubrenes

The manuscript entitled “Regioselective Synthesis of Substituted Rubrenes” is nicely written and excellent piece of work. Manuscript describes a method to generate Rubrene derivatives using a Diels Alder reaction and Phenyl lithium addition as key steps....

Synthesis of the Selective D 2 Receptor Agonist PNU-95666E from d -Phenylalanine Using a Sequential Oxidative Cyclization Strategy


(1)
22 Feb 2017

Good synthesis of enantiomerically pure (R)-sumanirole

PNU-95666E (sumanirole) was reported to be a highly selective D2 receptor full agonist. It was originally developed for the treatment of Parkinson’s disease. An eight steps synthesis was developed for the scale up of enantiomerically pure (R)-sumanirole with...

Silacyclohexadienylanionen bis- und tris-trimethylsilyl)-silacyclohexadiene


(2)
22 Feb 2017

Reproducible Reaction

Summary:

Synthesis of various silacycles has been reported. 

The Reaction of Interest:

Synthesis of t-BuSiHCl2 (18.5%, 50 mmol) via reaction of HSiCl3 (2 equiv) with t-BuLi.

Practical Observations:

  •  The reaction is reproducible, however 2 equiv...

Ir-Catalyzed Direct Borylation at the 4-Position of Pyrene


(3)
22 Feb 2017

Useful experimental

1. Synthesized compound 1 and another similar compound using the procedure described in this article.

2. Used 0.2 mmol Iridium instead of 0.1 mmol as reported. The reaction was monitored by TLC and after 48 hrs, all starting materials was consumed. The...

A Practical Synthesis of 3,3‐Difluorocyclobutane Carboxylic Acid


(3)
22 Feb 2017

Steven P. Cummings, Post-Doc

This communication was outstanding in providing a vast improvement to a very dangerous and potentially synthetically challenging method in obtaining 3,3-difluorocyclobutane carboxylic acid.  Ultimately the synthesis provided greater yields, easier workups,...