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Three new mononuclear group 12 complexes with benzimidazole


15 Dec 2016

Reproducible but very routine work

Summary:

This paper describes the synthesis of three iso-structural Zn(II), Cd(II), and Hg(II) complexes with 1-benzyl-2-phenyl-1H-benzimidazole (BPB). Single crystal X-ray determination of CdBPB and HgBPB were done along with Structural analysis of ZnBPB...

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Selective quenching of benzimidazole derivatives by Cu2+ metal ion


01 Jan 2017

Many details omitted which makes it clumsy to repeat

Summary:

This paper reports the binding effect of some novel benzimidazole derivatives with Cu2+ metal ion by solution spectral studies. Benzimidazole complexes (16) were studied for fluorescence quenching by Cu2+ in comparison to Fe3+, Mg2+, Ag+, K+...

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Synthesis and in Vitro Anti-Tumor Activity of A New Class of Acyclic Thioglycosides


31 Jan 2017

Innovative approach - Lower yields

Summary:

This paper reports the synthesis of a new class of acrylamide thioglycoside derivatives utilizing a one-pot synthesis. Further heating of the resultant glycosides with hydrazine is reported to give pyrazole derivatives. Among those synthesized,...

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Accelerating scientific publication in biology


03 Feb 2021

An important analysis of today's publication trends

A detailed observational study of the trends in biological sciences publishing, including analysis of time-to-publication, time-to-graduation, and the increasing minimum publication unit. The paper is interwoven with thoughtful analysis and perspective from...

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No Title


17 Mar 2021

Specinomycin restores susceptibly to resistant Mtb strains

Full disclosure – I know two of the authors of this paper professionally, however this has had no effect on my review (either good or bad) this work – but for the sake of transparency I thought I should mention this!

 

First impressions:

This publication...

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No Title


17 Mar 2021

Specinomycin restores susceptibly to resistant Mtb

Full disclosure – I know two of the authors of this paper professionally, however this has had no effect on my review of this work – but for the sake of transparency I thought I should mention this!

First impressions:

This publication has a very compelling...

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Isolation and reactions of .alpha.-lithio N,N-dimethylacetamide


09 Dec 2016

Reproducible Experimental

Summary: The paper discusses the synthesis, reactivity and stability of α-lithio N,N dimethylacetamide.

The paper described carefully the use of various solvents (pentane, THF) and their impact on the formation of the desired product.

It also described...

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A Convenient Synthesis of Novel Bifunctional Prochelators for Coupling to Bioactive Peptides for Radiometal Labelling


09 Dec 2016

Extremely helpful and reliable paper

 

Summary

The article describes the synthesis of cyclen based chelators which can accommodate and stabilize di-and trivalent metal ions for biomedical applications. The chelators were synthesized first by monoalkylating cyclen (1,4,7,10...

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DIPHENALDEHYDE


09 Dec 2016

Reliable Procedure

The procedure described in this paper is very reliable. The ozone should be used in a fully functional fume hood as described.

1. Synthesized 10.1 g of crude diphenaldehyde starting from 10.0 g of phenanthrene.

2. The crude 1H-NMR of product is 80%...

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Rapid determination of trace level copper in tea infusion samples by solid contact ion selective electrode


22 Dec 2016

Should include Mn & Al data for clarity

Summary:

A new copper selective solid-state electrode based on o-xylylenebis(N,N-diisobutyldithiocarbamate) ionophore has been described. It has been developed for selectively measuring the copper levels found in the tea infusion samples. Robust, cheap...

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Theoretical study of borazine and substituted borazines using density functional theory method


23 Dec 2016

Good theory. Experimental data can add value.

Summary:

This paper describes the theoretical study on borazine and substituted borazines by the means of density functional theory. Amino group was used as the common donor group while four acceptor groups namely –NO2, –C≡N, –COCl and –NMe2 were chosen...

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“On water” organic synthesis: a highly efficient and clean synthesis of 2-aryl/heteroaryl/styryl benzothiazoles and 2-alkyl/aryl alkyl benzothiazolines


01 Jan 2017

Excellent practical method. Highly recommended.

Summary:

A convenient, clean and environmentally benign method for ‘‘on water’’ synthesis of benzothiazoles/benzothiazolines has been described. Although previous methods are available in literature for synthesis of such compounds, the ease of operation,...

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A copper(II) complex of benzimidazole-based ligand: synthesis, structure, redox aspects and fluorescence properties


31 Jan 2017

aaaaaaa

This is a paper authored by myself. SO, I should not be able to write a review on it. This may lead to fake reviews. Please correct this issue.

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Eco-friendly synthesis of 2-substituted benzothiazoles catalyzed by cetyltrimethyl ammonium bromide (CTAB) in water


18 Feb 2017

Innovative but has errors which affects reproducibility

Summary:

This paper reports a CTAB-catalyzed method developed for the synthesis of 2-substituted benzothiazoles by the condensation of 2-aminothiophenol with aldehydes (RCHO: R = Alkyl, Aryl, Heteroaryl, 2-Arylformyl). Use of cetyltrimethyl ammonium...

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No Title


No Title


09 Nov 2020

2'F modifications in siRNA

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No Title


04 Feb 2021

A Useful Survey of Early Career Researchers

Toomey and colleagues report the results of a survey of 14 early career researchers (ECRs) about "open science". On a whole, these ECRs view open science positively, but hold reservations about the impact adopting open science practices might have on their...

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No Title


18 Mar 2021

pH Responsive Gold Nanocarriers Target Cancerous Cells

Gold nanocarriers are fused with a ph responsive and a hydrophobic polymers to form a system that will more readily detect as well as release drugs in enviroments that are inhabited by cancerous tumors. In the body, the cancerous tumors thrive in an...

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Catalytic Isomerization of Cyanoolefins Involved in the Adiponitrile Process. C−CN Bond Cleavage and Structure of the Nickel π-Allyl Cyanide Complex Ni(η3-1-Me-C3H4)(CN)(dppb)


09 Dec 2016

Helpful experimental; Some discrepancies observed in NMR

The article reports the catalytic isomerization of the branched cyanoolefin 2-methyl-3-butenenitrile (2M3BN) to the linear isomer 3-pentenenitrile (3PN) using nickel-phosphine complexes.

The authors report that the optimal catalytic experiment was carried...

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