Reviews

Sort By

Exploring factors that influence the practice of Open Science by early career health researchers: a mixed methods study


04 Feb 2021

A Useful Survey of Early Career Researchers

Toomey and colleagues report the results of a survey of 14 early career researchers (ECRs) about "open science". On a whole, these ECRs view open science positively, but hold reservations about the impact adopting open science practices might have on their...

(0)

Catalytic Isomerization of Cyanoolefins Involved in the Adiponitrile Process. C−CN Bond Cleavage and Structure of the Nickel π-Allyl Cyanide Complex Ni(η3-1-Me-C3H4)(CN)(dppb)


09 Dec 2016

Helpful experimental; Some discrepancies observed in NMR

The article reports the catalytic isomerization of the branched cyanoolefin 2-methyl-3-butenenitrile (2M3BN) to the linear isomer 3-pentenenitrile (3PN) using nickel-phosphine complexes.

The authors report that the optimal catalytic experiment was carried...

(0)

Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid: preparation and biological activity


09 Dec 2016

Procedure Adapted for Better Synthesis

Wanting to avoid a chromatographic separation of the Me esters as well as the greater expense of dimethyl itaconate, the reaction of alpha methyl benzylamine and itaconic acid was performed in xylene.  The reaction was performed by adding the amine at 110 to...

(0)

Construction of the Bicyclo[3.1.0]hexane Template of a Conformationally Locked Carbocyclic Adenosine via an Olefin Keto-Carbene Cycloaddition


09 Dec 2016

Experimental Yields Lower than Literature

Victor E. Marquez et. al. first introduced the concept of locked conformations, 2'-exo (North) and 3'-exo (South), of ribose ring in nucleosides. In this article the synthetic methodology and successful synthesis of receamic and conformationally locked South...

(0)

Photoinduced, Copper-Catalyzed Alkylation of Amides with Unactivated Secondary Alkyl Halides at Room Temperature


01 Nov 2016

Coupling N-alkylation of Amides with Secondary Alkyl Halides

Yapin Wang

Emaill: ywang2@lsuhsc.edu

1) Reaction of Standard Condition
Using photo-induced (hn 254), copper- catalyzed (10% CuI), two ratio base(LiOt-Bu), CH3CN/DMF as solvents and
stirring for 24 hrs at room temperature, Amides react with inactivated...

(0)

Practical Synthesis of Unsymmetrical Ureas from Isopropenyl Carbamates


09 Dec 2016

Mild, High Yielding Method

Ureas are very widely used synthetic targets in pharmaceutical industry especially as kinase inhibitors. Using this methodology we have synthesized thousands of unsymmetrical ureas as kinase inhibitors. This method is a very mild, high yielding and can work...

(0)

(R)- and (S)-4-TIPS-3-butyn-2-ol. Useful Precursors of Chiral Allenylzinc and Indium Reagents


01 Nov 2016

Synthesis of the optically active TIPS-functionalized acetylenic alcohols

A detailed route for the synthesis of the "S" enantiomer of 4-TIPS-3-butyn-2-ol in 90% enantiomeric purity by reduction of the ynone precursor by the Noyori catalytic system was reported by Marshall et al. The ease of catalyst preparation, operational...

(0)

Total Synthesis and Biological Evaluation of Glycolipids Plakosides A, B and Their Analogs


09 Dec 2016

Easy to follow procedures; yields not reproducible

In one of my Ph.D. projects where I was working on the total syntheses of glycosphingolipids, I followed this reference to prepare some of the intermediates. This is a very important publication in the glycolipid field since it is among the few papers that...

(0)

Benzobisthiazole-Based Donor–Acceptor Copolymer Semiconductors for Photovoltaic Cells and Highly Stable Field-Effect Transistors


09 Dec 2016

Good synthesis; product easy to isolate

Synthesized 2,6-Bis(3-dodecylthiophen-2-yl)benzobisthiazole following the procedure.

(1) The reaction was reproduced with higher yields (>25%).

(2) Added the 2-carboxylaldehydethiophene derviative by portions, used longer reaction time (24hs) and...

(0)

Relative Stability of Mixed [3 + 1] Tc and Re Complexes:  a Computational and Conceptual DFT Study


14 Dec 2016

Innovative study, but can be improved

Summary:

This paper describes the conceptual density functional studies on (3+1) complexes of both Re(V) as well as Tc(V). The tridentate ligands have been varied in order to study the effect of the various combinations of N, O and S chelating sites on...

(0)

An efficient green protocol for the synthesis of 2-aryl substituted benzothiazoles


14 Dec 2016

Good approach - less yields. Better methods reported already

Summary:

This paper reports the synthesis of 2-arylbenzothiazoles via cyclocondensation of 2-aminothiophenol with various aldehydes. Polyethylene glycol-400 (PEG-400) has been used as both solvent and catalyst for the process. The procedure applied, is...

(0)

Synthesis, characterization and DFT study of oxorhenium(v) complexes incorporating quinoline based tridentate ligands


22 Dec 2016

Good work, the basis set choice can be better

Summary:

The article presents the synthesis and characterization of two mononuclear Re(V) complexes. DFT and TD-DFT methods were employed for exploring the electronic structure and absorption spectra. Furthermore, the complexes were also tested for...

(0)

Sensitization-Initiated Electron Transfer for Photoredox Catalysis


07 Nov 2020

Review by a Non-Photoredox Organometallic Chemist

I followed this paper based on a need to synthesize their reported 7a as a substrate for a synthesis. I thought this method would be better than the previous Zinc-mediated cross-coupling approach. We found that the published procedure worked very well...

(0)

Mechanistic Studies of Cu(II) Binding to Amyloid-β Peptides and the Fluorescence and Redox Behaviors of the Resulting Complexes


02 Dec 2020

Fundamentally Sound

This paper was very helpful in my thesis research.  I had some difficulties reproducing the cyclic voltammetry results in the beginning, which I later attributed to the surface of my electrode.  Once I changed my polishing technique, I was able to reproduce...

(0)

Chemistry and physics of molecules and grains in space


29 Jan 2021

Loved the Thought

N/A

(0)

A network analysis of the propagation of evidence regarding the effectiveness of fat-controlled diets in the secondary prevention of coronary heart disease (CHD): Selective citation in reviews


14 Feb 2021

Excellent Exposition of Citation Bias

The concept of citation network analysis is not new, but it is important. In this manuscript, Dr. Leng uses Web of Science to analyze a subfield of papers about radomized controlled trials (RCTs) of coronay heart disease between 1965-1984. While this topic...

(0)