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An efficient green protocol for the synthesis of 2-aryl substituted benzothiazoles


14 Dec 2016

Good approach - less yields. Better methods reported already

Summary:

This paper reports the synthesis of 2-arylbenzothiazoles via cyclocondensation of 2-aminothiophenol with various aldehydes. Polyethylene glycol-400 (PEG-400) has been used as both solvent and catalyst for the process. The procedure applied, is...

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Synthesis, characterization and DFT study of oxorhenium(v) complexes incorporating quinoline based tridentate ligands


22 Dec 2016

Good work, the basis set choice can be better

Summary:

The article presents the synthesis and characterization of two mononuclear Re(V) complexes. DFT and TD-DFT methods were employed for exploring the electronic structure and absorption spectra. Furthermore, the complexes were also tested for...

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Enzymatic Synthesis of 7-Deoxy-N-acetylneuraminic Acid and 7-O-Methyl-N-acetylneuraminic Acid


09 Dec 2016

Modifications implemented to improve yields

I used the published synthethic methods for both deoxy and methoxy derivatives with some modifications and obtained a lot higher yields.

Deoxy: 2 eq of 1,1′-Thiocarbonyldiimidazole is enough (paper is 2.5 eq) and I used 1,2-dichloroethane instead of CH2Cl2...

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Use of the Nonionic Superbase P(MeNCH 2 CH 2 ) 3 N in the Selective Monoalkylation of Active-Methylene Compounds


09 Dec 2016

Not reproducible. Experimental produced mixture

This paper by Verkade and co-workers describes a superbase P(MeNCH2CH2)3N mediated selective monoalkylation of active-methylene compounds. Although malonate alkylation has been known for many years, it is very difficult to obtain really good yields for...

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Alkyl-Substituted Polyaminohydroxamic Acids:  A Novel Class of Targeted Histone Deacetylase Inhibitors


01 Nov 2016

Reproducible synthesis of compound 20

Synthesized (20) using the similar (not exactly same) procedure (Scheme 2) as was written in the paper.

1,4-Diaminobutane was firstly protected by mesitly chloride in DCM (overnight under reflux condition). The protected intermediate was then...

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Synthesis of Ethyl (1S,2R,3S,4S,5S)-2,3-O-(Isopropylidene)-4-Hydroxy-Bicyclo[3.1.0]Hexane-Carboxylate from L-Ribose: A Versatile Chiral Synthon for Preparation of Adenosine and P2 Receptor Ligands


01 Nov 2016

Convenient and reproducible synthetic methodology for North configured ribose containing mono phosphate

The article is about versatile synthetic strategy for preparing enantiomerically pure (N)-methanocarba ring containing monophosphates as a potent agonist for P2 receptors. 

I have successfully reproduced the synthesis of compound (2, MRS2339) from...

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Preparation and characterisation of fluorescent chitosans using 9-anthraldehyde as fluorophore


01 Nov 2016

Quality paper, good reproducibility


The procedure was adapted for the covalent attachment of an organometallic complex to chitosan backbone for use in a glucose oxidase bioanode. The procedure was done in both acidic (as in paper) and basic conditions (for comparison) for the following...

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High Turnover Number and Rapid, Room-Temperature Amination of Chloroarenes Using Saturated Carbene Ligands


09 Dec 2016

Reproducible Catalyst System

I need prepare a series of 2-amino-pyridines around 2003, and found this paper by SciFinder. 

I tested the reaction of 1-Boc-piperidine and 2-chloro-3-methyl- pyridine in 50mg scale using 5 mmol% catalysts.

The reactions were not completed in 3h at rt....

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Versatile Routes to Mono- and Bis(alkynyl) Manganese(II) and Manganese(III) Complexes via Manganocenes


01 Nov 2016

stanylation terminal hydrogen at ethynyl aryls

Unseld et al reported a novel mono and bis (alkynyl) Mn(II) and Mn(III) complexes with terminal or trimetyltin substituted acetylenes. In particular I was interested on stanylation terminal hydrogen at ethynyl aryls. I used this approach to stanylate...

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Synthesis of Sulfated Neoglycopolymers:  Selective P-Selectin Inhibitors


01 Nov 2016

Ron Okoth

I adopted the synthesis reported in the paper for selective sulfation of compound 2 in the synthesis of 3’O Sulfo β-methyl D-galactoside similar in structure to compound 2 save for a methyl group at the anomeric position in place of an azidoethyl. I altered...

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A General Synthetic Route to Defined, Biologically Active Multivalent Arrays


09 Dec 2016

Good experimental, sub DIC for EDCI

The coupling reaction between a carboxylic acid and an alcohol to generate an ester needs a carbodiimide coupling agent. in the reference, the authors report the use of EDCI to prepare compound 1. I have used the same procedure in the synthesis of 1 though...

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Oxorhenium-catalyzed deoxydehydration of glycols and epoxides


24 Dec 2016

Average reactions. Toxic solvents.

Summary:

Deoxydehydration of glycols and epoxides catalysed by oxorhenium complexes is described in this paper. Methyl trioxorhenium (MTO) was the choice as the catalyst for the reactions. The use of other catalytic conditions for such reactions are...

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Synthesis of Thiazolinone, Aminopyrazole, Pyrazolopyrimidine, and Pyrazolotriazine Derivatives Starting from 1-Naphthyl-2-Cyanoacetamide


31 Jan 2017

Good yields, but greener solvents recommended

Summary:

This paper reports 1-Naphthyl-2-cyanoacetamide used as a precursor for the synthesis of different novel heterocyclic moieties such as 5-Aminopyrazole, thiazolinone, pyrazolo[1,5-a]pyrimidine, 4H-pyrazolo[3,4-d]pyrimidin-4-one and pyrazolo[3,4-d...

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A density functional study of oxorhenium(V) complexes incorporating quinoline or isoquinoline carboxylic acids: structural, spectroscopic, and electronic properties


18 Feb 2017

Using Stuttgart basis set improves reproducibility

Summary:

This paper describes the density functional theoretical study on oxorhenium(V) complexes incorporating quinoline or isoquinoline carboxylic acids. The study is aimed at understanding causes for the difference in stabilities of particular isomers...

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Kinetic study of the complex reaction between copper(II) and 2-(2′-hydroxy-3′-methoxyphenyl)benzothiazole


09 Mar 2017

Kinetic study works well. Ligand synthesis can be improved.

Summary:

This paper reports an interesting property of the O, N and S donor ligand 2-(2’-Hydroxy-3’-methoxyphenyl)benzothiazole which makes it switch chelating donor sites from O, S (at pH < 5.0) to O, N (above pH 5.0) while reacting with Cu(II) acetate...

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