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High Turnover Number and Rapid, Room-Temperature Amination of Chloroarenes Using Saturated Carbene Ligands


09 Dec 2016

Reproducible Catalyst System

I need prepare a series of 2-amino-pyridines around 2003, and found this paper by SciFinder. 

I tested the reaction of 1-Boc-piperidine and 2-chloro-3-methyl- pyridine in 50mg scale using 5 mmol% catalysts.

The reactions were not completed in 3h at rt....

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Versatile Routes to Mono- and Bis(alkynyl) Manganese(II) and Manganese(III) Complexes via Manganocenes


01 Nov 2016

stanylation terminal hydrogen at ethynyl aryls

Unseld et al reported a novel mono and bis (alkynyl) Mn(II) and Mn(III) complexes with terminal or trimetyltin substituted acetylenes. In particular I was interested on stanylation terminal hydrogen at ethynyl aryls. I used this approach to stanylate...

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Synthesis of Sulfated Neoglycopolymers:  Selective P-Selectin Inhibitors


01 Nov 2016

Ron Okoth

I adopted the synthesis reported in the paper for selective sulfation of compound 2 in the synthesis of 3’O Sulfo β-methyl D-galactoside similar in structure to compound 2 save for a methyl group at the anomeric position in place of an azidoethyl. I altered...

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A General Synthetic Route to Defined, Biologically Active Multivalent Arrays


09 Dec 2016

Good experimental, sub DIC for EDCI

The coupling reaction between a carboxylic acid and an alcohol to generate an ester needs a carbodiimide coupling agent. in the reference, the authors report the use of EDCI to prepare compound 1. I have used the same procedure in the synthesis of 1 though...

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N-Heterocyclic Carbene-Catalyzed [3+4] Cycloaddition and Kinetic Resolution of Azomethine Imines


09 Dec 2016

Suggestions for Improvement

The authors describe the syntheses of several optically pure [3+4] cycloaddition product from the reaction of racemic azomethine imines and enals using indanol-derived catalyst D having N-mesityl substituent.  This work pertains to the development of...

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Oxorhenium-catalyzed deoxydehydration of glycols and epoxides


24 Dec 2016

Average reactions. Toxic solvents.

Summary:

Deoxydehydration of glycols and epoxides catalysed by oxorhenium complexes is described in this paper. Methyl trioxorhenium (MTO) was the choice as the catalyst for the reactions. The use of other catalytic conditions for such reactions are...

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Synthesis of Thiazolinone, Aminopyrazole, Pyrazolopyrimidine, and Pyrazolotriazine Derivatives Starting from 1-Naphthyl-2-Cyanoacetamide


31 Jan 2017

Good yields, but greener solvents recommended

Summary:

This paper reports 1-Naphthyl-2-cyanoacetamide used as a precursor for the synthesis of different novel heterocyclic moieties such as 5-Aminopyrazole, thiazolinone, pyrazolo[1,5-a]pyrimidine, 4H-pyrazolo[3,4-d]pyrimidin-4-one and pyrazolo[3,4-d...

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A density functional study of oxorhenium(V) complexes incorporating quinoline or isoquinoline carboxylic acids: structural, spectroscopic, and electronic properties


18 Feb 2017

Using Stuttgart basis set improves reproducibility

Summary:

This paper describes the density functional theoretical study on oxorhenium(V) complexes incorporating quinoline or isoquinoline carboxylic acids. The study is aimed at understanding causes for the difference in stabilities of particular isomers...

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Kinetic study of the complex reaction between copper(II) and 2-(2′-hydroxy-3′-methoxyphenyl)benzothiazole


09 Mar 2017

Kinetic study works well. Ligand synthesis can be improved.

Summary:

This paper reports an interesting property of the O, N and S donor ligand 2-(2’-Hydroxy-3’-methoxyphenyl)benzothiazole which makes it switch chelating donor sites from O, S (at pH < 5.0) to O, N (above pH 5.0) while reacting with Cu(II) acetate...

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DFT Studies of Dimerization Reactions of Boroles


27 Oct 2018

Comprehensive Study

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