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Isolation and reactions of .alpha.-lithio N,N-dimethylacetamide


09 Dec 2016

Reproducible Experimental

Summary: The paper discusses the synthesis, reactivity and stability of α-lithio N,N dimethylacetamide.

The paper described carefully the use of various solvents (pentane, THF) and their impact on the formation of the desired product.

It also described...

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A Convenient Synthesis of Novel Bifunctional Prochelators for Coupling to Bioactive Peptides for Radiometal Labelling


09 Dec 2016

Extremely helpful and reliable paper

 

Summary

The article describes the synthesis of cyclen based chelators which can accommodate and stabilize di-and trivalent metal ions for biomedical applications. The chelators were synthesized first by monoalkylating cyclen (1,4,7,10...

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DIPHENALDEHYDE


09 Dec 2016

Reliable Procedure

The procedure described in this paper is very reliable. The ozone should be used in a fully functional fume hood as described.

1. Synthesized 10.1 g of crude diphenaldehyde starting from 10.0 g of phenanthrene.

2. The crude 1H-NMR of product is 80%...

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Rapid determination of trace level copper in tea infusion samples by solid contact ion selective electrode


22 Dec 2016

Should include Mn & Al data for clarity

Summary:

A new copper selective solid-state electrode based on o-xylylenebis(N,N-diisobutyldithiocarbamate) ionophore has been described. It has been developed for selectively measuring the copper levels found in the tea infusion samples. Robust, cheap...

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Theoretical study of borazine and substituted borazines using density functional theory method


23 Dec 2016

Good theory. Experimental data can add value.

Summary:

This paper describes the theoretical study on borazine and substituted borazines by the means of density functional theory. Amino group was used as the common donor group while four acceptor groups namely –NO2, –C≡N, –COCl and –NMe2 were chosen...

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“On water” organic synthesis: a highly efficient and clean synthesis of 2-aryl/heteroaryl/styryl benzothiazoles and 2-alkyl/aryl alkyl benzothiazolines


01 Jan 2017

Excellent practical method. Highly recommended.

Summary:

A convenient, clean and environmentally benign method for ‘‘on water’’ synthesis of benzothiazoles/benzothiazolines has been described. Although previous methods are available in literature for synthesis of such compounds, the ease of operation,...

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Eco-friendly synthesis of 2-substituted benzothiazoles catalyzed by cetyltrimethyl ammonium bromide (CTAB) in water


18 Feb 2017

Innovative but has errors which affects reproducibility

Summary:

This paper reports a CTAB-catalyzed method developed for the synthesis of 2-substituted benzothiazoles by the condensation of 2-aminothiophenol with aldehydes (RCHO: R = Alkyl, Aryl, Heteroaryl, 2-Arylformyl). Use of cetyltrimethyl ammonium...

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Catalytic Isomerization of Cyanoolefins Involved in the Adiponitrile Process. C−CN Bond Cleavage and Structure of the Nickel π-Allyl Cyanide Complex Ni(η3-1-Me-C3H4)(CN)(dppb)


09 Dec 2016

Helpful experimental; Some discrepancies observed in NMR

The article reports the catalytic isomerization of the branched cyanoolefin 2-methyl-3-butenenitrile (2M3BN) to the linear isomer 3-pentenenitrile (3PN) using nickel-phosphine complexes.

The authors report that the optimal catalytic experiment was carried...

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Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid: preparation and biological activity


09 Dec 2016

Procedure Adapted for Better Synthesis

Wanting to avoid a chromatographic separation of the Me esters as well as the greater expense of dimethyl itaconate, the reaction of alpha methyl benzylamine and itaconic acid was performed in xylene.  The reaction was performed by adding the amine at 110 to...

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Construction of the Bicyclo[3.1.0]hexane Template of a Conformationally Locked Carbocyclic Adenosine via an Olefin Keto-Carbene Cycloaddition


09 Dec 2016

Experimental Yields Lower than Literature

Victor E. Marquez et. al. first introduced the concept of locked conformations, 2'-exo (North) and 3'-exo (South), of ribose ring in nucleosides. In this article the synthetic methodology and successful synthesis of receamic and conformationally locked South...

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Photoinduced, Copper-Catalyzed Alkylation of Amides with Unactivated Secondary Alkyl Halides at Room Temperature


01 Nov 2016

Coupling N-alkylation of Amides with Secondary Alkyl Halides

Yapin Wang

Emaill: ywang2@lsuhsc.edu

1) Reaction of Standard Condition
Using photo-induced (hn 254), copper- catalyzed (10% CuI), two ratio base(LiOt-Bu), CH3CN/DMF as solvents and
stirring for 24 hrs at room temperature, Amides react with inactivated...

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Practical Synthesis of Unsymmetrical Ureas from Isopropenyl Carbamates


09 Dec 2016

Mild, High Yielding Method

Ureas are very widely used synthetic targets in pharmaceutical industry especially as kinase inhibitors. Using this methodology we have synthesized thousands of unsymmetrical ureas as kinase inhibitors. This method is a very mild, high yielding and can work...

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(R)- and (S)-4-TIPS-3-butyn-2-ol. Useful Precursors of Chiral Allenylzinc and Indium Reagents


01 Nov 2016

Synthesis of the optically active TIPS-functionalized acetylenic alcohols

A detailed route for the synthesis of the "S" enantiomer of 4-TIPS-3-butyn-2-ol in 90% enantiomeric purity by reduction of the ynone precursor by the Noyori catalytic system was reported by Marshall et al. The ease of catalyst preparation, operational...

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Total Synthesis and Biological Evaluation of Glycolipids Plakosides A, B and Their Analogs


09 Dec 2016

Easy to follow procedures; yields not reproducible

In one of my Ph.D. projects where I was working on the total syntheses of glycosphingolipids, I followed this reference to prepare some of the intermediates. This is a very important publication in the glycolipid field since it is among the few papers that...

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Benzobisthiazole-Based Donor–Acceptor Copolymer Semiconductors for Photovoltaic Cells and Highly Stable Field-Effect Transistors


09 Dec 2016

Good synthesis; product easy to isolate

Synthesized 2,6-Bis(3-dodecylthiophen-2-yl)benzobisthiazole following the procedure.

(1) The reaction was reproduced with higher yields (>25%).

(2) Added the 2-carboxylaldehydethiophene derviative by portions, used longer reaction time (24hs) and...

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Relative Stability of Mixed [3 + 1] Tc and Re Complexes:  a Computational and Conceptual DFT Study


14 Dec 2016

Innovative study, but can be improved

Summary:

This paper describes the conceptual density functional studies on (3+1) complexes of both Re(V) as well as Tc(V). The tridentate ligands have been varied in order to study the effect of the various combinations of N, O and S chelating sites on...

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