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Regulatory review on status of FDA understanding of drug transporters. Suggest policies and guidance to direct the industry to advance drug development
The paper presents an innovative way to synthesis bi functional linker (in this case azido-amine linkers). The method used described as concurrent reaction-extraction taking place in one pot has attracted a lot of attention. In the synthesis of compound 1 a...
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An efficient and environmentally benign method for synthesis of 1,2-disubstituted and 2 substituted benzimidazoles has been described. Although previous methods are available in literature for synthesis of such compounds, the ease of operation,...
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A polymeric film as fluorescent sensor for detection of Pb2+ in aqueous solutions, synthesised from 1-vinylimidazole, poly(ethylene glycol) diacrylate and trimethylolpropane triacrylate has been described. The manuscript also describes the...
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This article describes a method for cyclic olefin polymerization employing a non-chelated monodentate benzimidazole Ni(II) complex. The specific reaction catalysed, is the vinyl polymerization of norbornene. The article also describes the methods...
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This paper describes a novel method for efficient synthesis of amides through reaction of carboxylic acids with amines by activation with P(OEt)3 and Iodine. The novelty lies in easy amidation of several primary and secondary amines to synthesize...
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This paper reports the synthesis of hexamethylenebisacetamide (HMBA) without organic solvent or gas protection via amide exchange reaction of hexamethylenediamine (HDA) with CH3CN and H2O catalysed by CuO. The authors report the method to be more...
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This paper reports the reactivity of the methylene group of 1-naphthyl-2-cyanoacetamide 1 which was tested towards different reagents. These new compounds have been reported to be characterized by elemental analysis, IR, 1HNMR, 13C NMR, and mass...
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This research article reports a study on the thermocehemical behaviour of halogen-containing molecules in atmospheric chemical processes. The thermodynamic and thermochemical model of these components helps in understanding the interactions in...
As th electronegativity of the R-groups on the catalyst increases, yields tended to drop below reported values. While annoying, the purity of the finale compound was excellent.
On a more positive note, the route proposed in this publication can be easily...
Response letter from reader suggesting their is now clinical evidence for salicylates casuing GI mucosa erosion and eventual bleeding.
Modifying electrodes, to include polymers instead of metals, could be beneficial for progressions in making prosthetics. This particular hybrid of a study and a review, focuses on the possibilities of improving cochlear and bionic eye prosthetics. The...
This article serves as a review of different methods that can be used to create polymeric nanoparticles. It gives immense details about the basics of polymeric nanoparticles including what they are as well as their numerous polymeric reagents that are used...
In this paper, selective bromination of perylene diimides is described. I was able to reproduce the bromination of 1a. However, the workup involves evaporating large volumes of bromine. I was able to isolate similar yields of products by quenching the...