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This paper describes amazingly shortest synthesis for such a complex macrolide. Geldanamycin was synthesized in 20 steps using key steps such as Cu-catalyzed intramolecular amidation. I have used synthetic strategy to synthesize prodrug of geldanamycin with...
The experimental section was adequately detailed in procedure and results describing necessary DMA and MDSC data were given. No substantial differences were recorded while reproducing similar results.
The manuscript entitled “Regioselective Synthesis of Substituted Rubrenes” is nicely written and excellent piece of work. Manuscript describes a method to generate Rubrene derivatives using a Diels Alder reaction and Phenyl lithium addition as key steps....
Enhancement of carrier mobility due to a secondary structural arrangement resulting from the substituents in a porphyrin transistor was observed. OSCFETs based on two different porphyrin derivatives displayed excellent mobilities of 2.57 and 0.48 cm2 V-1 s-1....
The data in this paper is veryw ell laid out. The data is easily reproducable and the work is easy to follow.
Chun Liu and Weibo Yang
Chem. Commun., 2009, 6267-6269
DOI: 10.1039/B912364D
t-Bu amine (50 mmol) and methyl acrylate (50 mmol) were dissolved in MeOH (10 mL) and stirred overnight under nitrogen. The secondary amine was isolated by Kugelrohr distillation after the MeOH had been removed by rotary evaporation. The purified material...
N-(4-carboxyphenyl) anthranilic acid (compound 31)
A mixture of 2-chlorobenzoic acid (1 mmol), 4-aminobenzoic acid (1 mmol), K2CO3 (2 mmol), Cu powder (0.009 mmol), and Cu2O (0.009 mmol) in 0.3 mL of 2-ethoxyethanol was refluxed at 130°C under inert...
Well written paper. The technique of using a removabile filler to direct pore size in a membrane is an innovative method and should be studied more.
Great paper highlighting the PK of propranolol. Went into ADME properties and expanding indications
Regulatory review on status of FDA understanding of drug transporters. Suggest policies and guidance to direct the industry to advance drug development
The paper presents an innovative way to synthesis bi functional linker (in this case azido-amine linkers). The method used described as concurrent reaction-extraction taking place in one pot has attracted a lot of attention. In the synthesis of compound 1 a...
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An efficient and environmentally benign method for synthesis of 1,2-disubstituted and 2 substituted benzimidazoles has been described. Although previous methods are available in literature for synthesis of such compounds, the ease of operation,...
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A polymeric film as fluorescent sensor for detection of Pb2+ in aqueous solutions, synthesised from 1-vinylimidazole, poly(ethylene glycol) diacrylate and trimethylolpropane triacrylate has been described. The manuscript also describes the...
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This article describes a method for cyclic olefin polymerization employing a non-chelated monodentate benzimidazole Ni(II) complex. The specific reaction catalysed, is the vinyl polymerization of norbornene. The article also describes the methods...
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This paper describes a novel method for efficient synthesis of amides through reaction of carboxylic acids with amines by activation with P(OEt)3 and Iodine. The novelty lies in easy amidation of several primary and secondary amines to synthesize...
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This paper reports the synthesis of hexamethylenebisacetamide (HMBA) without organic solvent or gas protection via amide exchange reaction of hexamethylenediamine (HDA) with CH3CN and H2O catalysed by CuO. The authors report the method to be more...
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This paper reports the reactivity of the methylene group of 1-naphthyl-2-cyanoacetamide 1 which was tested towards different reagents. These new compounds have been reported to be characterized by elemental analysis, IR, 1HNMR, 13C NMR, and mass...
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This research article reports a study on the thermocehemical behaviour of halogen-containing molecules in atmospheric chemical processes. The thermodynamic and thermochemical model of these components helps in understanding the interactions in...