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The methodology developed by Montchamp and co-workers demonstrated a mild and reliable way to esterify the monosubstituted phosphinic acids.
I repeated the preparation of substrate 3 as the entry 5 in table 1 followed their protocol. The reaction...
H. Kondo and E. Ochiai Ann. Chem. 1929 470 p224 reported using the iodo group to block Pschorr diazonium cyclizations into an aromatic carbon position when making polycyclic aromatics. This protocol was repeated by K. Goto and H. Sudzuki Bull. Chem. Soc. Jpn...
The manuscript entitled ''A cyclic triphenylamine dimer for organic field-effect transistors with high performance'' is a nice piece of work. A new OFET based on triphenylamine units with a macrocyclic architect has been described with its potential use as...
The preparation of tetramethylguanidium azide was successfully carried out following the literature preparation (JOC 31, 1426 (1966)). Hydrazoic acid was prepared as a Et2O solution by adding conc HCl over 30 minutes to a ice cold solution of NaN3 in...
This work by Lafrance and co-work represents a very mild means to induce the decarboxylation of malonic acid derivatives with 1,1-carbonyldiimidazole (CDI). The reactive intermediate carbonyl imidazole moiety can be trapped with various nucleophiles in an...
Under nitrogen, 1,3-dichlorobenzene (1 mmol) and 1,3-diaminobenzene were dissolved in toluene (15 mL). Sodium-tert-butoxide (NaO-t-Bu) (3 mmol), Ni(cod)2 (0.1 mmol), and DPPF (0.3mmol) were added to the solution at room temperature. The reaction mixture was...
The hydrostannation of alkynes is frequently used for the synthesis of vinyl stannanes, which can be subjected to further modifications via a Stille coupling. The major drawbacks of this process result from the difficulties which arise in the control of the...
PNU-95666E (sumanirole) was reported to be a highly selective D2 receptor full agonist. It was originally developed for the treatment of Parkinson’s disease. An eight steps synthesis was developed for the scale up of enantiomerically pure (R)-sumanirole with...
I used this published synthetic method for making similar N-alkylated benzodiazepine molecules. The reaction was very reliable and good yielding in case of exact molecule but in my molecule, which was basically 1,4-benzodiazepine-2-one derivative, this...
Synthesized (3) and a compound similar to (4) but with protection on -OH groups.
For (3): Dissolving CBr4 in dichloromethane instead of pyridine gave a better yield as it involved using only one solvent throughout the reaction.
For (4): The formation...
Authours: Jean-Luc Montchamp, Feng Tian, Matthew E. Hart, and J. W. Frost*
Journal: J. Org. Chem. 1996, 61, 3897-3899
After searching for an alternate protecting group for the protection of cis-dihydrocatechols, it was found that the butane-bisacetals...
The experimental section was adequately detailed in procedure and results describing necessary DMA and MDSC data were given. No substantial differences were recorded while reproducing similar results.
This paper does a thorough analysis of structure and property relationships. The analyiss is thorougouh and well backed up by data. I found the secion on deswollen materials particularly helpful and interesting.
This paper describes amazingly shortest synthesis for such a complex macrolide. Geldanamycin was synthesized in 20 steps using key steps such as Cu-catalyzed intramolecular amidation. I have used synthetic strategy to synthesize prodrug of geldanamycin with...
The manuscript entitled “Regioselective Synthesis of Substituted Rubrenes” is nicely written and excellent piece of work. Manuscript describes a method to generate Rubrene derivatives using a Diels Alder reaction and Phenyl lithium addition as key steps....
Enhancement of carrier mobility due to a secondary structural arrangement resulting from the substituents in a porphyrin transistor was observed. OSCFETs based on two different porphyrin derivatives displayed excellent mobilities of 2.57 and 0.48 cm2 V-1 s-1....
The data in this paper is veryw ell laid out. The data is easily reproducable and the work is easy to follow.
Chun Liu and Weibo Yang
Chem. Commun., 2009, 6267-6269
DOI: 10.1039/B912364D
t-Bu amine (50 mmol) and methyl acrylate (50 mmol) were dissolved in MeOH (10 mL) and stirred overnight under nitrogen. The secondary amine was isolated by Kugelrohr distillation after the MeOH had been removed by rotary evaporation. The purified material...