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Mild Decarboxylative Activation of Malonic Acid Derivatives by 1,1′-Carbonyldiimidazole


09 Dec 2016

Wide versatility and good reproducibility

This work by Lafrance and co-work represents a very mild means to induce the decarboxylation of malonic acid derivatives with 1,1-carbonyldiimidazole (CDI). The reactive intermediate carbonyl imidazole moiety can be trapped with various nucleophiles in an...

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Preparation of meta-polyaniline and its related poly(iminoarylene)s by nickel-catalyzed polycondensation of aryl dichlorides with aryl primary diamines


09 Dec 2016

Synthesis of poly(m-aniline) Table 1, Run 1

Under nitrogen, 1,3-dichlorobenzene (1 mmol) and 1,3-diaminobenzene were dissolved in toluene (15 mL). Sodium-tert-butoxide (NaO-t-Bu) (3 mmol), Ni(cod)2 (0.1 mmol), and DPPF (0.3mmol) were added to the solution at room temperature. The reaction mixture was...

(2)

Mo(CO) 3 (CN- t- Bu) 3 (MoBI 3 ), a New Efficient Catalyst for Regioselective Hydrostannations


01 Nov 2016

Hydrostannation of Terminal Acetylenes

The hydrostannation of alkynes is frequently used for the synthesis of vinyl stannanes, which can be subjected to further modifications via a Stille coupling. The major drawbacks of this process result from the difficulties which arise in the control of the...

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Synthesis of the Selective D 2 Receptor Agonist PNU-95666E from d -Phenylalanine Using a Sequential Oxidative Cyclization Strategy


22 Feb 2017

Good synthesis of enantiomerically pure (R)-sumanirole

PNU-95666E (sumanirole) was reported to be a highly selective D2 receptor full agonist. It was originally developed for the treatment of Parkinson’s disease. An eight steps synthesis was developed for the scale up of enantiomerically pure (R)-sumanirole with...

(1)

Palladium-Catalysed Synthesis of Enantiopure 1,2,4,5-Tetrahydro-1,4-benzodiazepin-3-(3H)-one Derivatives


01 Nov 2016

Synthesis of N-alkylated Benzodiazepines

I used this published synthetic method for making similar N-alkylated benzodiazepine molecules. The reaction was very reliable and good yielding in case of exact molecule but in my molecule, which was basically 1,4-benzodiazepine-2-one derivative, this...

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Enantioselective formation of functionalized 1,3-disubstituted allenes: synthesis of .alpha.-allenic .omega.-carbomethoxy alcohols of high optical purity


09 Dec 2016

Few Experimental Modifications Implemented to Improve Yield

Synthesized (3) and a compound similar to (4) but with protection on -OH groups. 

For (3): Dissolving CBr4 in dichloromethane instead of pyridine gave a better yield as it involved using only one solvent throughout the reaction. 

For (4): The formation...

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1,1'-Carbonylbis(3-methylimidazolium) triflate: an efficient reagent for aminoacylations


23 Nov 2016

Butane 2,3-Bisacetal Protection of Vicinal Diequatorial Diols

Authours: Jean-Luc Montchamp, Feng Tian, Matthew E. Hart, and J. W. Frost* 

Journal: J. Org. Chem. 1996, 61, 3897-3899 

After searching for an alternate protecting group for the protection of cis-dihydrocatechols, it was found that the butane-bisacetals...

(1)

Effect of isocyanate content on thermal and mechanical properties of polyurea


04 May 2017

Influence of morphology on the mechanical properties of PU

The experimental section was adequately detailed in procedure and results describing necessary DMA and MDSC data were given.  No substantial differences were recorded while reproducing similar results.

(1)

Structure–mechanical property correlations of model siloxane elastomers with controlled network topology


23 Feb 2017

Incredible Depth of Data

This paper does a thorough analysis of structure and property relationships. The analyiss is thorougouh and well backed up by data. I found the secion on deswollen materials particularly helpful and interesting. 

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Total Synthesis of the Hsp90 Inhibitor Geldanamycin


09 Dec 2016

Amazingly short synthesis for complex macrolide

This paper describes amazingly shortest synthesis for such a complex macrolide. Geldanamycin was synthesized in 20 steps using key steps such as Cu-catalyzed intramolecular amidation. I have used synthetic strategy to synthesize prodrug of geldanamycin with...

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pH-Dependent Si-Fluorescein Hypochlorous Acid Fluorescent Probe: Spirocycle Ring-Opening and Excess Hypochlorous Acid-Induced Chlorination


09 Dec 2016

Novel and less expensive Hypo-SiF synthesis

  • Hypo-SiF is uniquely new in finding the high concentration of HOCl
  • Hypo-SiF is reported to be good in finding the HOCl concentration and pH of the media simultaneously at lower concentrtion
  • To obtain clear results, Hypo-SiF needs to be improved and...

(1)

Regioselective synthesis of substituted rubrenes


22 Feb 2017

Excellent method to generate rubrenes

The manuscript entitled “Regioselective Synthesis of Substituted Rubrenes” is nicely written and excellent piece of work. Manuscript describes a method to generate Rubrene derivatives using a Diels Alder reaction and Phenyl lithium addition as key steps....

(1)

Dramatic enhancement of carrier mobility via effective secondary structural arrangement resulting from the substituents in a porphyrin transistor


09 Dec 2016

Thorough study of porphyrin transistor derivatives

Enhancement of carrier mobility due to a secondary structural arrangement resulting from the substituents in a porphyrin transistor was observed. OSCFETs based on two different porphyrin derivatives displayed excellent mobilities of 2.57 and 0.48 cm2 V-1 s-1....

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Elastomeric Networks with Bimodal Chain-Length Distributions


23 Feb 2017

Strong Fundamental Polymer Structure Information

The data in this paper is veryw ell laid out. The data is easily reproducable and the work is easy to follow. 

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Structural and conformational studies of 2-phenyl-1,3,2-diaza- and -dioxaboracycloalkanes


19 Dec 2016

Experimental Details

t-Bu amine (50 mmol) and methyl acrylate (50 mmol) were dissolved in MeOH (10 mL) and stirred overnight under nitrogen.  The secondary amine was isolated by Kugelrohr distillation after the MeOH had been removed by rotary evaporation.  The purified material...

(1)

Regioselective Copper-Catalyzed Amination of Chlorobenzoic Acids:  Synthesis and Solid-State Structures ofN-Aryl Anthranilic Acid Derivatives


08 Feb 2017

Synthesis of N-(4-carboxyphenyl) anthranilic acid

N-(4-carboxyphenyl) anthranilic acid (compound 31)

A mixture of 2-chlorobenzoic acid (1 mmol), 4-aminobenzoic acid (1 mmol), K2CO3 (2 mmol), Cu powder (0.009 mmol), and Cu2O (0.009 mmol) in 0.3 mL of 2-ethoxyethanol was refluxed at 130°C under inert...

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Macroporous silicone biomaterials with modified surface chemistry: Production and characterization


23 Feb 2017

Innovative Technique to Create a Membrane

Well written paper. The technique of using a removabile filler to direct pore size in a membrane is an innovative method and should be studied more. 

(1)

Total Synthesis of Spirobacillene A


08 Feb 2017

Replicable (w/ Minor Modifications)

This paper was about first total synthesis of an indole alkaloid, Spirobacillene A and the key step of this approach was a Lewis acid catalyzed spirocyclization of an anisole derivative onto a tethered ynone.

I tried to replicate some of these reactions...

(1)

Desymmetrization Reactions:  Efficient Preparation of Unsymmetrically Substituted Linker Molecules


09 Dec 2016

Innovative,one-pot method to synthesize bifunctional linkers

The paper presents an innovative way to synthesis bi functional linker (in this case azido-amine linkers). The method used described as concurrent reaction-extraction taking place in one pot has attracted a lot of attention. In the synthesis of compound 1 a...

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