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Synthesis, Characterization, and Catalase Activity of a Water-Soluble diMnIIIComplex of a Sulphonato-Substituted Schiff Base Ligand: An Efficient Catalyst for H2O2Disproportionation


09 Dec 2016

Good experimental, though extended rxn time beneficial

This paper describes synthesis, characterization, and catalase activity of a water-soluble diMn(III) complex of a sulphonato-substituted Schiff-base ligand. DiMn(III) complex is highly efficient to disproportionate hydrogen peroxide in basic aqueous solutions...

(2)

Fluorescence Studies of Poly(p-phenyleneethynylene)s: The Effect of Anthracene Substitution


16 Feb 2017

Reproducible Synthesis

Swager et al reported the synthesis and fluorescence studies of poly(p-phenyleneethynylene)s. The experimental section, they made 4 different alkoxybenzenes using p-hydroquinone. I used this paper as a reference to synthesis a series of molecules:...

(3)

N,N‘-Ditosylhydrazine:  A Convenient Reagent for Facile Synthesis of Diazoacetates†


23 Feb 2017

Reproducible, but Yields Lower Than Described

Summary:

An efficient method for the synthesis of diazoacetates from the coresponding bromoacetates and N,N'-ditosylhydrazine has been described. In fact, diazoacetates can be prepared from various alcohols by acylation with bromoacetyl bromide, followed by...

(7)

SYNTHESIS AND CHARACTERIZATION OF EFFICIENT TWO-PHOTON ABSORPTION CHROMOPHORES WITH INCREASED DIMENSIONALITY


18 Feb 2017

Sub grignard for n-BuLi for nmr clean product

Spirobifluorene: Synthesized spirobifluorene following the reported procedure (page 324-325) using  2-iodobiphenyl as starting material. It was difficult to isolate nmr-clean product and the yield was low, although they reported very high yield. Instead of...

(3)

PtCl 2 -Catalyzed Rearrangement of Methylenecyclopropanes


17 Feb 2017

Good for Aldehydes, Modification for Ketone Substrates

This communication by Furstner and co-worker reported a novel rearrangement of methylenecyclopropanes 3 for the construction of variously substituted cyclobutenes and derivatives.

I am particularly interested in the preparation of cyclopropylidene bearing...

(3)

Structure−Activity Relationships of 1-(2-Deoxy-2-fluoro-β- l -arabino- furanosyl)pyrimidine Nucleosides as Anti-Hepatitis B Virus Agents


01 Nov 2016

reproducible synthesis process

Synthesized (10) on beach in the lab and also pilot plant when I was working in company. The synthesis procedue is reproducible even in a 5 L scale reaction in the lab.  The starting material L-Xylose canot be abtained from natural substances which results...

(2)

A novel Schiff-base as a Cu(II) ion fluorescent sensor in aqueous solution


18 Feb 2017

The role of DMSO in the system needs to be investigated

Summary:

This paper reports the synthesis of a Schiff base ligand (L) by reaction of 5,5’-methylene-bis-salicylaldehyde with amidol (2,4-diaminophenol). The applicability of this ligand as a new fluorescent Cu(II) sensor in aqueous medium was assessed. A...

(3)

Synthesis of 9-(2-deoxy-2-fluoro--D-arabinofuranosyl)adenine bearing a selectively removable protecting group


01 Nov 2016

Synthesis of 2'-fluorinated Adenosine

The article presents a facile and practical method to prepare fluorinated nucleosides, which are known for antitumor and antiviral activity, through introducing fluorine at the up-side of the 2’-carbon of nucleosides.

Particularly, I used this synthetic...

(2)

High-Performance Single-Crystal-Based Organic Field-Effect Transistors from π-Extended Porphyrin Derivatives


01 Nov 2016

single crystal porphrins based organic materials

In this manuscript, the single crystalline wires were grown from π-extended porphyrin derivatives TTPH2 1  and TTPZn 2, and their unique electronic properties in OFET devices along with single-crystal structures. was readily obtained in relatively high...

(2)

Preparation of thermally stable and soluble mesitylcopper(I) and its application in organic synthesis


18 Feb 2017

Synthesis of mesitylcopper

Synthesized mesitylcopper by following the procedure. 

(1) High quality anhydrous solvents (THF/dioxane/Toluene) and good argon or nitrogen protection for all the operations are key to get high yield and quality product, since the mesitylcoppor solution is...

(3)

Ir-Catalyzed Direct Borylation at the 4-Position of Pyrene


22 Feb 2017

Useful experimental

1. Synthesized compound 1 and another similar compound using the procedure described in this article.

2. Used 0.2 mmol Iridium instead of 0.1 mmol as reported. The reaction was monitored by TLC and after 48 hrs, all starting materials was consumed. The...

(3)

Comparative Study of Different Cross-Linking Agents for the Immobilization of Functionalized Carbon Nanotubes within a Chitosan Film Supported on a Graphite−Epoxy Composite Electrode


23 Feb 2017

very versatile procedure

Covalent attachment of small organometallic molecules to COOH-MWCNTs was successfully achieved using the described methods of EDC/NHS coupling. A qualitative yield was achieved which allowed for a unique route to create redox active MWCNTs. After exploration...

(4)

Bile Acid-Based 1,2,4-Trioxanes: Synthesis and Antimalarial Assessment(1)


19 Feb 2017

Decarboxylative oxidation of lithocholic acid

Summary:

A new series of bile acid-based trioxanes have been synthesized and assessed for their antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route.

The Reaction of Interest:

Decarboxylative oxidation of...

(2)

Synthesis of 9-(2-Deoxy-2-fluoro-.BETA.-D-arabinofuranosyl)adenine Bearing a Selectively Removable Protecting Group.


01 Nov 2016

Synthesis of 2'-fluorinated nucleosides

The article presents a facile and practical method to prepare fluorinated nucleosides, which are known for antitumor and antiviral activity, through introducing fluorine at the up-side of the 2’-carbon of nucleosides.

 

Particularly, I used this...

(1)

Tetraalkylammonium salts in heck-type reactions using an alkali metal hydrogen carbonate or an alkali metal acetate as the base


19 Dec 2016

Seminal paper for phase-transfer Heck-Mizoroki cross coupling

A pinacle reaction of the synthesis required the cross coupling off a two highly heteroatom functionalised fragments, the use of traditional Heck conditions, such as palladium (II) acetate, triphenyl phosphine and triethylamine afforded poor yields and...

(1)

Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications


09 Dec 2016

Reproducible on smaller scale

Synthesized 2-[N-( tert -Butoxycarbonyl)amino]thiophene (25) and a similar compound (2-[N-( tert -Butoxycarbonyl)amino]-5-bromothiophene) following the same procedure described in the article as method F.

For the synthesis of 25, the reaction was scaled...

(1)

Orthosilicate-Mediated Esterification of Monosubstituted Phosphinic Acids


01 Nov 2016

Orthosilicate-Mediated Esterification of Monosubstituted Phosphinic Acids

The methodology developed by Montchamp and co-workers demonstrated a mild and reliable way to esterify the monosubstituted phosphinic acids.

 

I repeated the preparation of substrate 3 as the entry 5 in table 1 followed their protocol.  The reaction...

(1)

Über die Konstitution des Sinomenins


01 Nov 2016

Blocking diazonium couplings of aromatic rings

H. Kondo and E. Ochiai Ann. Chem. 1929 470 p224 reported using the iodo group to block Pschorr diazonium cyclizations into an aromatic carbon position when making polycyclic aromatics.  This protocol was repeated by K. Goto and H. Sudzuki Bull. Chem. Soc. Jpn...

(1)

A Cyclic Triphenylamine Dimer for Organic Field-Effect Transistors with High Performance


01 Nov 2016

Review of the novel materials for future organic electronics

The manuscript entitled ''A cyclic triphenylamine dimer for organic field-effect transistors with high performance'' is a nice piece of work. A new OFET based on triphenylamine units with a macrocyclic architect has been described with its potential use as...

(1)

Synthesis and Azidolysis of 2-Chlorotetramethylguanidine. Synthetic Utility of Hexa- and Tetramethylguanidinium Azide


14 Jan 2017

Good synthesis but experimental lacking some useful details

 

The preparation of tetramethylguanidium azide was successfully carried out following the literature preparation (JOC 31, 1426 (1966)).  Hydrazoic acid was prepared as a Et2O solution by adding conc HCl over 30 minutes to a ice cold solution of NaN3 in...

(1)