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Rapid and Green Synthesis of some Benzothiazole-, Benzimidazole- and Benzoxazole-2-thiol Derivatives Using Copper Sulfate in Aqueous Media


09 Mar 2017

Reproducible method. Certain aspects can be improved.

Summary:

An easy, green, efficient and simple for synthesis of derivatives of benzimidazole-, benzothiazole- and benzoxazole-2-thiol has been described. Although previous methods are available in literature for synthesis of such compounds, this method...

(1)

High-performance wearable thermoelectric generator with self-healing, recycling, and Lego-like reconfiguring capabilities


Yesterday

Wearable Energy Review

Summary

A team of researcher at the University of Colorado Boulder recently developed a new wearable device that transforms the body into a biological battery. Wearing jewelry like a ring or bracelet users can harvest the energy from their own body heat.

...

(1)

On a new synthesis of sterpurene and the bioactivity of some related Chondrostereum purpureum sesquiterpene metabolites


09 Dec 2016

Reliable procedure but modifications helpful

The article by Strunz and co-workers reported a total synthesis of sterpurene and the bioactivity of some related sesquiterpene metabolites.

I am particularly interested in the preparation of intermediate 14 (4-step synthesis, Scheme 3) since it could...

(1)

Hydroboration. 97. Synthesis of New Exceptional Chloroborane−Lewis Base Adducts for Hydroboration. Dioxane−Monochloroborane as a Superior Reagent for the Selective Hydroboration of Terminal Alkenes†


09 Dec 2016

Equivalency of reagents key for successful synthesis

Review: Synthesized the same compound of Dioxane-Monochloroborane by the reaction of Sodium Borohydride with Dioxane-borontrichloride (experimental section, Page 5364). I found the equivalency of the reagents is very important for this reaction. The reaction...

(1)

Butane 2,3-Bisacetal Protection of Vicinal Diequatorial Diols


09 Dec 2016

Clear, Detailed Paper

After searching for an alternate protecting group for the protection of cis-dihydrocatechols, it was found that the butane-bisacetals were more resilient to hydrolysis. This is crucial when protecting group stabiity is required for acetals that are exposed to...

(2)

Efficient, one-pot syntheses of biologically active α-linked glycolipids


09 Dec 2016

Adjustments needed to increase efficiency of methodology

The methodology described in this article is very valuable for scientists working with glycosphingolipids. It provided a one-pot syntheses of alpha-linked glycolipids with the possibility of using substrates with unsaturations in the fatty acid side...

(1)

Synthesis, Characterization, and Catalase Activity of a Water-Soluble diMnIIIComplex of a Sulphonato-Substituted Schiff Base Ligand: An Efficient Catalyst for H2O2Disproportionation


09 Dec 2016

Good experimental, though extended rxn time beneficial

This paper describes synthesis, characterization, and catalase activity of a water-soluble diMn(III) complex of a sulphonato-substituted Schiff-base ligand. DiMn(III) complex is highly efficient to disproportionate hydrogen peroxide in basic aqueous solutions...

(2)

Fluorescence Studies of Poly(p-phenyleneethynylene)s: The Effect of Anthracene Substitution


16 Feb 2017

Reproducible Synthesis

Swager et al reported the synthesis and fluorescence studies of poly(p-phenyleneethynylene)s. The experimental section, they made 4 different alkoxybenzenes using p-hydroquinone. I used this paper as a reference to synthesis a series of molecules:...

(3)

N-Heterocyclic Carbene-Catalyzed [3+4] Cycloaddition and Kinetic Resolution of Azomethine Imines


09 Dec 2016

Suggestions for Improvement

The authors describe the syntheses of several optically pure [3+4] cycloaddition product from the reaction of racemic azomethine imines and enals using indanol-derived catalyst D having N-mesityl substituent.  This work pertains to the development of...

(1)

N,N‘-Ditosylhydrazine:  A Convenient Reagent for Facile Synthesis of Diazoacetates†


23 Feb 2017

Reproducible, but Yields Lower Than Described

Summary:

An efficient method for the synthesis of diazoacetates from the coresponding bromoacetates and N,N'-ditosylhydrazine has been described. In fact, diazoacetates can be prepared from various alcohols by acylation with bromoacetyl bromide, followed by...

(7)

SYNTHESIS AND CHARACTERIZATION OF EFFICIENT TWO-PHOTON ABSORPTION CHROMOPHORES WITH INCREASED DIMENSIONALITY


18 Feb 2017

Sub grignard for n-BuLi for nmr clean product

Spirobifluorene: Synthesized spirobifluorene following the reported procedure (page 324-325) using  2-iodobiphenyl as starting material. It was difficult to isolate nmr-clean product and the yield was low, although they reported very high yield. Instead of...

(3)

Structure−Activity Relationships of 1-(2-Deoxy-2-fluoro-β- l -arabino- furanosyl)pyrimidine Nucleosides as Anti-Hepatitis B Virus Agents


01 Nov 2016

reproducible synthesis process

Synthesized (10) on beach in the lab and also pilot plant when I was working in company. The synthesis procedue is reproducible even in a 5 L scale reaction in the lab.  The starting material L-Xylose canot be abtained from natural substances which results...

(2)

PtCl 2 -Catalyzed Rearrangement of Methylenecyclopropanes


17 Feb 2017

Good for Aldehydes, Modification for Ketone Substrates

This communication by Furstner and co-worker reported a novel rearrangement of methylenecyclopropanes 3 for the construction of variously substituted cyclobutenes and derivatives.

I am particularly interested in the preparation of cyclopropylidene bearing...

(5)

Synthesis of 9-(2-deoxy-2-fluoro--D-arabinofuranosyl)adenine bearing a selectively removable protecting group


01 Nov 2016

Synthesis of 2'-fluorinated Adenosine

The article presents a facile and practical method to prepare fluorinated nucleosides, which are known for antitumor and antiviral activity, through introducing fluorine at the up-side of the 2’-carbon of nucleosides.

Particularly, I used this synthetic...

(2)

High-Performance Single-Crystal-Based Organic Field-Effect Transistors from π-Extended Porphyrin Derivatives


01 Nov 2016

single crystal porphrins based organic materials

In this manuscript, the single crystalline wires were grown from π-extended porphyrin derivatives TTPH2 1  and TTPZn 2, and their unique electronic properties in OFET devices along with single-crystal structures. was readily obtained in relatively high...

(2)

A novel Schiff-base as a Cu(II) ion fluorescent sensor in aqueous solution


18 Feb 2017

The role of DMSO in the system needs to be investigated

Summary:

This paper reports the synthesis of a Schiff base ligand (L) by reaction of 5,5’-methylene-bis-salicylaldehyde with amidol (2,4-diaminophenol). The applicability of this ligand as a new fluorescent Cu(II) sensor in aqueous medium was assessed. A...

(4)

Preparation of thermally stable and soluble mesitylcopper(I) and its application in organic synthesis


18 Feb 2017

Synthesis of mesitylcopper

Synthesized mesitylcopper by following the procedure. 

(1) High quality anhydrous solvents (THF/dioxane/Toluene) and good argon or nitrogen protection for all the operations are key to get high yield and quality product, since the mesitylcoppor solution is...

(3)

Ir-Catalyzed Direct Borylation at the 4-Position of Pyrene


22 Feb 2017

Useful experimental

1. Synthesized compound 1 and another similar compound using the procedure described in this article.

2. Used 0.2 mmol Iridium instead of 0.1 mmol as reported. The reaction was monitored by TLC and after 48 hrs, all starting materials was consumed. The...

(3)

Comparative Study of Different Cross-Linking Agents for the Immobilization of Functionalized Carbon Nanotubes within a Chitosan Film Supported on a Graphite−Epoxy Composite Electrode


23 Feb 2017

very versatile procedure

Covalent attachment of small organometallic molecules to COOH-MWCNTs was successfully achieved using the described methods of EDC/NHS coupling. A qualitative yield was achieved which allowed for a unique route to create redox active MWCNTs. After exploration...

(4)

Bile Acid-Based 1,2,4-Trioxanes: Synthesis and Antimalarial Assessment(1)


19 Feb 2017

Decarboxylative oxidation of lithocholic acid

Summary:

A new series of bile acid-based trioxanes have been synthesized and assessed for their antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route.

The Reaction of Interest:

Decarboxylative oxidation of...

(2)