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Macrophages provide a transient muscle stem cell niche via NAMPT secretion


01 May 2021

Promising Discovery In Satellite Cell Research

Summary
Researchers discovered a protein which triggers satellite cells to proliferate and heal. In  sh with severe muscle damage, injection of NAMPT led to the regeneration of muscle and the return of normal movement. This study demonstrates that NAMPT, can...

(1)

A commercially available fluorescence chemosensor for copper ion and its application in bioimaging


30 Mar 2017

Cu(II) exclusively detectable. Cu(I) can't be stabilized.

Summary:

This paper reports the chemosensing properties of a commercially available fluorescent probe, 1,8-diamino naphthalene for copper ion detection in the aqueous medium and its application in bioimaging. The proposed mechanism involves fluorescence...

(2)

Site-directed ligand discovery


31 Jan 2021

Important contribution to fragment hit-finding technologies

This paper by Erlanson and colleagues describes the disulfide tethering technique, which has proven to be a reproducible and versatile method for finding fragment hits. The main advance is the covalent targeting of the fragment library to a specific site on a...

(1)

Stimuli-Responsive Polymersomes as Nanocarriers for Drug and Gene Delivery


11 Mar 2021

Polymersomes in nanocarriers and varied environments

   The premise of the article is to summarize the ways in which stimuli- responsive polymersomes are involved in the creation of nanocarriers, as well as their contribution to each nanocarrier's performance in varied environments or stimuli. Polymersomes are...

(1)

Synthesis and reactions of the cyclic silyl peroxide 1,1,4,4-tetramethyl-2,3-dioxa-1,4-disilacyclohexane


09 Dec 2016

Exact Procedure Not Provided By Authors

Summary:

The first simple cyclic silyl peroxide, namely 1,1,4,4,-tetramethyl-1,4-disila-2,3-dioxane, was prepared by classical synthetic methodology from its corresponding cyclic disilazane and the urea complex of hydrogen peroxide.

The Reaction of...

(1)

Method and basis set analysis of oxorhenium(V) complexes for theoretical calculations


24 Dec 2016

Well established computational procedure

Summary:

This paper describes the analysis of methods and basis sets for theoretical calculations on oxorhenium(V) complexes. A variety of ligand systems with different coordinating atoms (N, O, P, S, Cl, and Se) were incorporated into this study. Two...

(2)

A Green Route for the One-Pot Synthesis of 1,2-Disubstituted Benzimidazoles Using Iron(III) Phosphate under Solventless Conditions


12 Mar 2017

Easy process to reproduce

Summary:

A simple, convenient, and environment-friendly method for synthesis of 1,2-disubstituted benzimidazoles in high yields under extremely mild conditions, has been described. The methodology described, involves condensation of o-phenylenediamine...

(1)

No Title


01 Mar 2021

Promising Discovery in Satellite Cell Research

Summary

Researchers discovered a protein which triggers satellite cells to proliferate and heal. In fish with severe muscle damage, injection of NAMPT led to the regeneration of muscle and the return of normal movement. This study demonstrates that NAMPT,...

(1)

A New Short Synthesis of 3-Substituted 5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indoles (Amino-CBIs)


22 Mar 2021

Efficient and reproducible method to obtain Amino-CBIs

The presented route provides an efficient and highly reproducible method to obtain penultimate allyl-protected intermediates of 3-Substituted 5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indoles (amino-CBIs).  De-allylation utilizing Grubbs carbene proved...

(1)

3D Printed “Earable” Smart Devices for Real-Time Detection of Core Body Temperature


01 May 2021

Review Of 3D Printed “Earable” Smart Devices

Summary:
This paper describes a novel way to measure core body temperature using a three-dimensional (3D) printed wearable “earable” smart device. The device is designed to be worn on the ear and track core body temperature from the tympanic membrane (i.e.,...

(1)

A Practical Synthesis of C2-Symmetric Chiral Binaphthyl Ketone Catalyst


09 Dec 2016

Several Recommendations for Improved Synthesis

Summary:

A practical synthesis of 11-membered C2-symmetric binaphthyl ketone (R)-1, a catalyst for asymmetric epoxidation, was developed. This manuscript describes the single example of chiral resolution of (±)-1,1’-Binaphthyl-2,2’-dicarboxylic acid [(±)-6...

(1)

CHLOROSULFONATION OF SOME POLYNUCLEAR HETEROCYCLIC COMPOUNDS


09 Dec 2016

Lacking complete isolation/purification procedures

This article reported the synthesis of different sulfonyl chloride of polynuclear heterocyclic compounds which are very important intermediates to form different derivatives like sulfonates. Unfortunately, this paper is lacking a complete isolation and...

(1)

A New Approach to the Oxidation of Methylquinolines with Selenium Dioxide


01 Nov 2016

4-methylquinoline oxidation really works

Review:

This article/communication described the preapration of 2 and 4-quinolinecarboxaldehyde using 2 and 4-methylquinoline in the presence of selenous acid in refluxing dioxane. While the procedure explicitly stated the use of selenous acid, selenium...

(1)

Copper-Catalyzed Synthesis of Benzimidazoles via Cascade Reactions ofo-Haloacetanilide Derivatives with Amidine Hydrochlorides


22 Mar 2017

Slight adjustments will give more yields

Summary:

This paper reports an efficient method for synthesising benzimidazoles through cascade reactions of o-haloacetoanilide derivatives with amidine hydrochlorides. 10 mol % CuBr was used as the catalyst and Cs2CO3 as the base. The reactions were...

(1)

A convenient one-pot synthesis of 2-substituted benzimidazoles


23 Mar 2017

Good Synthesis procedure

Summary:

An efficient and green method for synthesis of 2 substituted benzimidazoles has been described. Despite previous methods being available in literature for synthesis of such compounds, the ease of operation, use of common and non-toxic solvent and...

(1)

No Title


15 Mar 2021

CRISPR-based test for Mycobacterium tuberculosis

This paper describes the development and use of a CRISPR based diagnostic for Mycobacterium tuberculosis (Mtb). I was particularly interested in this paper because it hits all the things which my research is focused on – Mtb, diagnostics, and the practical...

(1)

Preparation and characterization of uniform, spherical particles of Y2O2S and Y2O2S:Eu


29 Jan 2017

Neat but a bit complicated synthesis

Yttrium oxysulfide – Y2O2S is knows an excellent host material for the Eu(III) activated red emission phosphor, which has been used for decades in the CRT displays and conventional TV due to its excellent brightness, color purity, life time and compatibility...

(1)

A Practical Synthesis of Rosuvastatin and Other Statin Intermediates


22 Mar 2017

Good synthesis method

Summary:

This paper reports an efficient method for aldol condensation between a methyl 3-hydroxy-5-oxohexanoate derivative and a pyrimidine carbaldehyde comprising the core structure of rosuvastatin. The authors have described the method as an...

(1)

No Title


26 Feb 2021

Review of framework for improving knee rehabilitation

Summary:

A framework for improving knee rehabilitation and reducing ACL injury incidence and reinjury rates post anterior cruciate ligament reconstruction has been described. The framework encourages a global approach, whereby ‘proximal’ is not confined to...

(1)

No Title


26 Feb 2021

Review of 3D Printed “Earable” Smart Devices

Summary:

This paper describes a novel way to measure core body temperature using a three-dimensional (3D) printed wearable “earable” smart device. The device is designed to be worn on the ear and track core body temperature from the tympanic membrane (i.e.,...

(1)