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A commercially available fluorescence chemosensor for copper ion and its application in bioimaging


(1)
30 Mar 2017

Cu(II) exclusively detectable. Cu(I) can't be stabilized.

Summary:

This paper reports the chemosensing properties of a commercially available fluorescent probe, 1,8-diamino naphthalene for copper ion detection in the aqueous medium and its application in bioimaging. The proposed mechanism involves fluorescence...

Synthesis and reactions of the cyclic silyl peroxide 1,1,4,4-tetramethyl-2,3-dioxa-1,4-disilacyclohexane


(1)
09 Dec 2016

Exact Procedure Not Provided By Authors

Summary:

The first simple cyclic silyl peroxide, namely 1,1,4,4,-tetramethyl-1,4-disila-2,3-dioxane, was prepared by classical synthetic methodology from its corresponding cyclic disilazane and the urea complex of hydrogen peroxide.

The Reaction of...

Method and basis set analysis of oxorhenium(V) complexes for theoretical calculations


(2)
24 Dec 2016

Well established computational procedure

Summary:

This paper describes the analysis of methods and basis sets for theoretical calculations on oxorhenium(V) complexes. A variety of ligand systems with different coordinating atoms (N, O, P, S, Cl, and Se) were incorporated into this study. Two...

A Green Route for the One-Pot Synthesis of 1,2-Disubstituted Benzimidazoles Using Iron(III) Phosphate under Solventless Conditions


(1)
12 Mar 2017

Easy process to reproduce

Summary:

A simple, convenient, and environment-friendly method for synthesis of 1,2-disubstituted benzimidazoles in high yields under extremely mild conditions, has been described. The methodology described, involves condensation of o-phenylenediamine...

A New Approach to the Oxidation of Methylquinolines with Selenium Dioxide


(1)
01 Nov 2016

4-methylquinoline oxidation really works

Review:

This article/communication described the preapration of 2 and 4-quinolinecarboxaldehyde using 2 and 4-methylquinoline in the presence of selenous acid in refluxing dioxane. While the procedure explicitly stated the use of selenous acid, selenium...

Copper-Catalyzed Synthesis of Benzimidazoles via Cascade Reactions of o -Haloacetanilide Derivatives with Amidine Hydrochlorides


(1)
22 Mar 2017

Slight adjustments will give more yields

Summary:

This paper reports an efficient method for synthesising benzimidazoles through cascade reactions of o-haloacetoanilide derivatives with amidine hydrochlorides. 10 mol % CuBr was used as the catalyst and Cs2CO3 as the base. The reactions were...

A convenient one-pot synthesis of 2-substituted benzimidazoles


(1)
23 Mar 2017

Good Synthesis procedure

Summary:

An efficient and green method for synthesis of 2 substituted benzimidazoles has been described. Despite previous methods being available in literature for synthesis of such compounds, the ease of operation, use of common and non-toxic solvent and...

Preparation and characterization of uniform, spherical particles of Y2O2S and Y2O2S:Eu


(1)
29 Jan 2017

Neat but a bit complicated synthesis

Yttrium oxysulfide – Y2O2S is knows an excellent host material for the Eu(III) activated red emission phosphor, which has been used for decades in the CRT displays and conventional TV due to its excellent brightness, color purity, life time and compatibility...

A Practical Synthesis of Rosuvastatin and Other Statin Intermediates


(1)
22 Mar 2017

Good synthesis method

Summary:

This paper reports an efficient method for aldol condensation between a methyl 3-hydroxy-5-oxohexanoate derivative and a pyrimidine carbaldehyde comprising the core structure of rosuvastatin. The authors have described the method as an...

An efficient method for the preparation of N,N-disubstituted 1,2-diamines


(3)
18 Feb 2017

Good synthesis with comments for improvement

The article presents a synthetic methodology to prepare chiral N,N-disubstituted, 1,2-diamines, which can be convenient precursors to tridentate ligands.

Particularly, I used the synthetic route using cyclohexane-1,2-diamine (both racemic and enatiopure)...

Highly Chemoselective Reduction of Amides (Primary, Secondary, Tertiary) to Alcohols using SmI2/Amine/H2O under Mild Conditions


(3)
18 Feb 2017

Good but some limitations

 

Description of Study

Szostak and coworkers reported highly chemoselective reduction of amides ( primary, secondary, Tertiary) to alcohols using SmI2  /Amine /H2O under mild conditions.  They  reduced amide to alcohol by stirring amide (0.1mmol) with...

New Well-Defined Poly(2,7-fluorene) Derivatives:  Photoluminescence and Base Doping


(2)
17 Feb 2017

Robust synthesis of difuctional fluorene derivatives

Synthesized compounds 1, 2 and 8. These reactions were successfully reproduced at large scales (up to 10 times). 

  1. Synthesis of compound 1: Maintaining the reaction temperature at -78 oC is critical for achiving disubstitution. The crude materials...

Facile Synthesis of Structurally Diverse 3,3′-Disubstituted 1,1′-Binaphthyl-2,2′-diamines in Optically Pure Forms


(2)
09 Dec 2016

Simple BINAM ligand synthesis,improvements made for scale-up

Maruoka et al. developed a new synthetic route to access 3,3’-disubstituted BINAM compounds which are nitrogen derivatives of popular axial chiral ligands BINOL and BINAP. Their multi step approach involves in partial hydrogenation of BINAM to H8-BINAM,...

An Efficient Method for Solution-Phase Parallel Synthesis of 2-Quinoxalinol Salen Schiff-Base Ligands


(2)
09 Dec 2016

Excellent reproducibility, some improvements suggested

This article describes an efficient method for solution-phase parallel synthesis of 2-quinoxalinol salen Schiff-base ligands. The novelty of this article is the synthesis of a new category of ligands using Schiff-base condensation of an aldehyde with a...

Hydrodeoxygenation of acetic acid in a microreactor


(2)
01 Jan 2017

Feasible and efficient process. Easily reproducible.

Summary:

This study reports the hydrodeoxygenation (HDO) of acetic acid. The authors have chosen a packed bed microreactor for the purpose. The reason for put forward by the authors for choosing micro reactor is its efficiency in operation under reduced...

Nickel-Catalyzed Isomerization of 2-Methyl-3-butenenitrile†


(2)
09 Dec 2016

Modifications to catalytic isomerization of 2M3BN to 3PN

This article reports the catalytic isomerization of the branched isomer 2-methyl-3-butenenitrile (2M3BN) to the linear isomer 3-pentenenitrile (3PN) by DPEphos nickel species.

The species involved in the isomerization reaction were investigated by...

Catalytic Enantioselective Friedel-Crafts Alkylation of Indoles with Nitroalkenes by Using a Simple Thiourea Organocatalyst


(2)
17 Feb 2017

Good reported synthesis with room for improvement

Review:

This article describes the structure optimization and initial mechanistic understanding of a simple thiourea catalyst for the enantioselective alkylation of indoles with nitroalkenes.  The indole ring has proven to be a “privileged” structure in...

Toward Optimized High-Relaxivity MRI Agents:  The Effect of Ligand Basicity on the Thermodynamic Stability of Hexadentate Hydroxypyridonate/Catecholate Gadolinium(III) Complexes


(2)
09 Dec 2016

Tweaks Necessary to Improve Yield

Summary:

This paper describes the synthesis of a new hydroxypyridinone applicable for MRI technology. The basicity was measured and related to the thermodynamic stability with Gd.

 

Reaction of interest:

Our interest was the formation of the ring...

Nano ceria catalyzed synthesis of substituted benzimidazole, benzothiazole, and benzoxazole in aqueous media


(2)
24 Dec 2016

Work is good, descriptions could be better

Summary:

This paper reports a methodology for synthesis of substituted benzimidazole, benzothiazole, and benzoxazole in aqueous media. The method is novel in its approach of utilizing water as the medium, making it fit for a green chemistry protocol. The...

Silacyclohexadienylanionen bis- und tris-trimethylsilyl)-silacyclohexadiene


(2)
22 Feb 2017

Reproducible Reaction

Summary:

Synthesis of various silacycles has been reported. 

The Reaction of Interest:

Synthesis of t-BuSiHCl2 (18.5%, 50 mmol) via reaction of HSiCl3 (2 equiv) with t-BuLi.

Practical Observations:

  •  The reaction is reproducible, however 2 equiv...