Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

2'F modifications in siRNA


Topic Area
Biology / biological chemistry
Article Type
Primary Research

Logic / Design


Point of Paper
Mostly clear
Experimental Design
Good
Main Conclusions
Mostly supposed by evidence presented

Reproducibility


Key Procedures
Able to reproduce most
# Procedures Attempted
1 to 3
Of Attempted, # Reproduced
Most

Improvements


Replicated Methods Exactly:
Minor Changes
Reviewer Improvements
Slight improvements

Versatility


Applicability to Other Fields
Probably not
Use in Own Work
Did not attempt

Clarity


Overall Clarity
Very good

Impact


Impact
Signifcantly advances the field

Transparency


Funding Sources
Clearly disclosed
Conflicts of Interest
Not aware of any

Other


Safety Concerns
None or clearly mentioned


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