• 10.1021/jp802038p
  • The Journal of Physical Chemistry B
  • Volume 112
  • June 2008
  • pp 8406-8411

Mechanistic Studies of Cu(II) Binding to Amyloid-β Peptides and the Fluorescence and Redox Behaviors of the Resulting Complexes

Fundamentally Sound


Topic Area
Analytical Chemistry
Article Type
Primary Research

Logic / Design


Point of Paper
Very clear
Main Conclusions
Supported by evidence presented

Reproducibility


Key Procedures
Able to reproduce most
# Procedures Attempted
1 to 3
Of Attempted, # Reproduced
All

Improvements


Replicated Methods Exactly:
Exactly
Reviewer Improvements
No improvements made

Versatility


Applicability to Other Fields
Not sure
Use in Own Work
Yes, and it was useful

Clarity


Overall Clarity
Very good

Impact


Impact
Not Sure

Transparency


Funding Sources
Clearly disclosed
Conflicts of Interest
Not aware of any

Details


This paper was very helpful in my thesis research.  I had some difficulties reproducing the cyclic voltammetry results in the beginning, which I later attributed to the surface of my electrode.  Once I changed my polishing technique, I was able to reproduce as described and then transfer those methods to an AB-Fe system to investigate the presence of a Fenton-like reaction as shown below.

I found the detailed incorporation of equations for the determination of quantum yield (1) and a dissociation constant (2-4) via fluoresence spectroscopy particularly useful in my thesis work



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