• 10.1021/ol800749w
  • Organic Letters
  • Volume 10
  • June 2008
  • pp 2477-2479

Total Synthesis of the Hsp90 Inhibitor Geldanamycin

Amazingly short synthesis for complex macrolide


This paper describes amazingly shortest synthesis for such a complex macrolide. Geldanamycin was synthesized in 20 steps using key steps such as Cu-catalyzed intramolecular amidation. I have used synthetic strategy to synthesize prodrug of geldanamycin with little modification amidation. Actually CuI was interfering with my substrate so I changed Cu to Palladium chemistry (Buchwald amination). Great work.

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