• 10.1021/jo0507643
  • The Journal of Organic Chemistry
  • Volume 70
  • August 2005
  • pp 6960-6963

Practical Synthesis of Unsymmetrical Ureas from Isopropenyl Carbamates

Mild, High Yielding Method


Ureas are very widely used synthetic targets in pharmaceutical industry especially as kinase inhibitors. Using this methodology we have synthesized thousands of unsymmetrical ureas as kinase inhibitors. This method is a very mild, high yielding and can work for different scaffolds unlike other methods. In some cases product can be isolated by filtration. Formation of symmetrical urea was observed in very few reactions. We used this method for parallel synthesis as well as for scale up synthesis.  

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