Ureas are very widely used synthetic targets in pharmaceutical industry especially as kinase inhibitors. Using this methodology we have synthesized thousands of unsymmetrical ureas as kinase inhibitors. This method is a very mild, high yielding and can work for different scaffolds unlike other methods. In some cases product can be isolated by filtration. Formation of symmetrical urea was observed in very few reactions. We used this method for parallel synthesis as well as for scale up synthesis.