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With Tag: Selective Monoalkylation

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Use of the Nonionic Superbase P(MeNCH 2 CH 2 ) 3 N in the Selective Monoalkylation of Active-Methylene Compounds

Subramaniam Arumugam, Dale McLeod, John G. Verkade
The Journal of Organic Chemistry | 1998 | 10.1021/jo972350i

The symmetric active-methylene compounds CH 2 (CO 2 Et) 2 and CH 2 [C(O)Me] 2 are selectively monoalkylated in the presence of 1.1 equiv of a variety of alkyl halides and 1 equiv of the nonionic superbase P(MeNCH 2 CH 2 ) 3 N in 85−98% yields in 30 min at...

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