A natural bond orbital analysis of the distonic bicyclo[2.2.1]hepta-2-ene-5-yl-7-ylium radical cation interprets its structure and radical character by a three-center two-electron bond between C2, C3, and C7 (a bishomoaromatic stabilization) and a singly...
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Smart phones and tablets have revolutionized how we communicate, access and use information, work, travel, play and learn. Chemistry education and the field of chemistry have not surprisingly been positively impacted by this technologyâ¦
It is recognized widely that enzymes promote reactions by providing a pathway that proceeds through a transition state of lower energy. In principle, further rate enhancements could be achieved if intermediates are prevented from relaxing to their lowest...
Developing cleaner chemical processes often involves sophisticated flow-chemistry equipment that is not available in many economically developing countries. For reactions where it is the data that are important rather than the physical product, the networking...
A classic calcium aluminate has been modified to create an inorganic electride that can be used as a promoter of the catalytic synthesis of ammonia.
Ironâsulfur clusters are common cofactors in biological systems and are involved in a range of functions, including electron transfer, substrate binding and activation. These clusters are usually ligated by the cysteine residues of a protein, but there are...
There has been only one example reported so far of a terminal phosphorus monoxide complex. The chemistry of this functional group, therefore, is unexplored compared with others containing main-group elements.
With the intention of improving synthetic efficiency, organic chemists have turned to bioinspired organocascade or domino processes that generate multiple bonds and stereocentres in a single operation. However, despite the great importance of substituted...
With energy swiftly rising to the top of the world's agenda, Harry B. Gray at the California Institute of Technology looks at how chemistry can help to harness the power of the Sun to meet the world's energy needs.
The interaction between a viral capsid and its genome governs crucial steps in the life cycle of a virus, such as assembly and genome uncoating. Tuning cargoâcapsid interactions is also essential for successful design and cargo delivery in engineered viral...
The unusual electronic properties of graphene have generated great interest in research into other two-dimensional materials. Furthermore, introducing pores with controlled size and distribution could be a way of tuning these electronic properties.
The electrochemical oxygen reduction reaction is the limiting half-reaction for low-temperature hydrogen fuel cells, and currently costly Pt-based electrocatalysts are used to generate adequate rates. Although most other metals are not stable in typical...
N,Nâ²,Nâ³-trialkylbenzene-1,3,5-tricarboxamides (BTAs) self-assemble by means of strong, threefold α-helix-type intermolecular hydrogen bonding into well-defined, helical, one-dimensional columnar aggregates. When a stereogenic centre is introduced into...
Nature 505, 199â203 (2014) Making complex and highly functionalized molecules from simple, relatively unreactive substrates is a goal of many modern synthetic techniques. The development of protocols that activate CâH bonds for reaction have in recent...
Science 345, 909â912 (2014) For many molecules, organic and inorganic alike, X-ray crystallography is arguably the most reliable way to obtain detailed information on the positioning of atoms within the structure. However, crystallography, by definition,...
Interest in saturated N-heterocycles as scaffolds for the synthesis of bioactive molecules is increasing. Reliable and predictable synthetic methods for the preparation of these compounds, especially medium-sized rings, are limited. We describe the...