Papers

With Tag: Drug Discovery

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Can a ‘flawless’ live vector vaccine strain be engineered?

James E Galen, Myron M Levine
Trends in Microbiology | 2001 | 10.1016/S0966-842X(01)02096-0

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Potassium ion channels and human disease: phenotypes to drug targets?

Current Opinion in Biotechnology | 1998 | 10.1016/S0958-1669(98)80133-X

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Enzymatic activity characterization of SARS coronavirus 3C‐like protease by fluorescence resonance energy transfer technique1

Lili Chen, Tao Sun, Y E Fei, Haibin Luo, Hualiang Jiang, Jianhua Cai, Jing Chen, Jingkang Shen, Xu Shen, Shuai Chen
Acta Pharmacologica Sinica | 2005 | 10.1111/j.1745-7254.2005.00010.x

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Pharmacokinetic interactions induced by content variation of major water-soluble components of Danshen preparation in rats

Wenliang Yang, Lin Zhang, Xiaoquan Liu, Yan Wang, Yuancheng Chen, Wanwen Cao, Yuan Cao, Bobo Chang
Acta Pharmacologica Sinica | 2010 | 10.1038/aps.2010.27

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Activation of AMPK inhibits cardiomyocyte hypertrophy by modulating of the FOXO1/MuRF1 signaling pathway in vitro

Yugang Dong, Yuedong Ma, Chen Liu, Zhaojun Xiong, Junyi Zeng, Rongsen Meng, Haining Wang, Baolin Chen
Acta Pharmacologica Sinica | 2010 | 10.1038/aps.2010.73

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Synergistic suppression of human breast cancer cells by combination of plumbagin and zoledronic acid In vitro

An Qin, Xiuguo Han, Qiming Fan, Han Qiao, Tingting Tang, Yugang Wang, Wei Yan, Tingyu Wang
Acta Pharmacologica Sinica | 2015 | 10.1038/aps.2015.42

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Efficacy of subantimicrobial-dose doxycycline against nitrosative stress in chronic periodontitis

Alexandra Cr Abreve, Sandu Florin Alb, Alina Elena Pârvu, M Taulescu, Ciun
Acta Pharmacologica Sinica | 2013 | 10.1038/aps.2012.129

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Perspectives of antimony compounds in oncology

Diego Perez, J L Arias, Armando Cabrera, Pankaj Sharma, Noe Rosas
Acta Pharmacologica Sinica | 2008 | 10.1111/j.1745-7254.2008.00818.x

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A hearty solution for acute myeloid leukemia.

Yiju Hung, H Eugene Liu
Acta Pharmacologica Sinica | 2012 | 10.1038/aps.2011.197

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Involvement of Bcl-2, Src, and ER|[alpha]| in gossypol-mediated growth inhibition and apoptosis in human uterine leiomyoma and myometrial cells

Jieyun Zhou, Yan Zhu, Yang Cao, Lin Cao, Tingting Zhang, Jianfeng Zhang, Shuwu Xie
Acta Pharmacologica Sinica | 2010 | 10.1038/aps.2010.153

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Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1.

Rong Zeng, Shuai Zhao, Guohui Cui, Yan Chen
Acta Pharmacologica Sinica | 2012 | 10.1038/aps.2011.143

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Inhibition of STAT3 expression by siRNA suppresses growth and induces apoptosis in laryngeal cancer cells

L Wen, X U Deqi, Xingyi Zhang, Yueting Shao, Lifang Gao, Xuejian Zhao
Acta Pharmacologica Sinica | 2005 | 10.1111/j.1745-7254.2005.00053.x

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Molecular modeling, quantum polarized ligand docking and structure-based 3D-QSAR analysis of the imidazole series as dual AT1 and ETA receptor antagonists

K D Singh, Karthikeyan Muthusamy
Acta Pharmacologica Sinica | 2013 | 10.1038/aps.2013.129

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The effect of poor compliance on the pharmacokinetics of carbamazepine and its epoxide metabolite using Monte Carlo simulation

Junjie Ding, Zheng Jiao, Yi Wang, Yunjian Zhang
Acta Pharmacologica Sinica | 2012 | 10.1038/aps.2012.135

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Permeation-enhancing effects of chitosan formulations on recombinant hirudin-2 by nasal delivery in vitro and in vivo

Yujie Zhang, Changhua Ma, Wanliang Lu, Xiaoliang Wang, Jianning Sun, Qiang Zhang, Xuan Zhang
Acta Pharmacologica Sinica | 2005 | 10.1111/j.1745-7254.2005.00174.x

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Prenatal nicotine exposure enhances the susceptibility to metabolic syndrome in adult offspring rats fed high-fat diet via alteration of HPA axis-associated neuroendocrine metabolic programming

Youying Lei, Li Zhang, Liping Xia, Lang Shen, Hui Wang, Jacques Magdalou, Dan Xu, Lian Liu
Acta Pharmacologica Sinica | 2013 | 10.1038/aps.2013.171

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Effects of propofol on ischemia-induced ventricular arrhythmias and mitochondrial ATP-sensitive potassium channels

Baogui Sun, Longsheng Song, Junyan Yao, Jiang Hong, Cheng Qian, Qiang Liu, Rong Chen, Xiaoyu Li, Shaowen Liu
Acta Pharmacologica Sinica | 2012 | 10.1038/aps.2012.86

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Selective |[alpha]|1B- and |[alpha]|1D-adrenoceptor antagonists suppress noradrenaline-induced activation, proliferation and ECM secretion of rat hepatic stellate cells in vitro

Yong Ma, Wei Wei, Tilong Ding, Tingting Liu
Acta Pharmacologica Sinica | 2014 | 10.1038/aps.2014.84

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Involvement of REST corepressor 3 in prognosis of human hepatitis B

Jihua Xue, Zhi Chen, Xiaowei Xu, Shanshan Wu, Feng Chen, Min Zheng
Acta Pharmacologica Sinica | 2011 | 10.1038/aps.2011.49

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Astragalus polysaccharides suppress ICAM-1 and VCAM-1 expression in TNF-|[alpha]|-treated human vascular endothelial cells by blocking NF-|[kappa]|B activation

Yong Man, Yuan Cao, Jian Li, Tao Shen, Yue Qiao, Yajun Lin, Beidong Chen, Shu Wang, Yang Ruan, Yuping Zhu
Acta Pharmacologica Sinica | 2013 | 10.1038/aps.2013.46

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