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Paractamol or Aspirin?

Jennings Gh
BMJ | 1965 | 10.1136/bmj.1.5445.1311



Bithiophene-Imide-Based Polymeric Semiconductors for Field-Effect Transistors: Synthesis, Structure−Property Correlations, Charge Carrier Polarity, and Device Stability

Xugang Guo, Rocio Ponce Ortiz, Yan Zheng, Yan Hu, Yong-Young Noh, Kang-Jun Baeg, Antonio Facchetti, Tobin J. Marks
Journal of the American Chemical Society | 2011 | 10.1021/ja107678m

Developing new high-mobility polymeric semiconductors with good processability and excellent device environmental stability is essential for organic electronics. We report the synthesis, characterization, manipulation of charge carrier polarity, and device...


pH-Dependent Si-Fluorescein Hypochlorous Acid Fluorescent Probe: Spirocycle Ring-Opening and Excess Hypochlorous Acid-Induced Chlorination

Daniel J. Dyer, Narsimha Sattenapally, Colleen N. Scott, Matthew E. McCarroll, Quinn A. Best
Journal of the American Chemical Society | 2013 | 10.1021/ja401426s

We report the synthesis and characterization of a fluorescent probe (Hypo-SiF) designed for the detection of hypochlorous acid (HOCl) using a silicon analogue of fluorescein (SiF). The probe is regulated in an “off–on” fashion by a highly selective thioether...


Stereocontrolled construction of the trans-tetrahydrofuran units in Annonaceous acetogenins

Shi-Kai Tian, Zhi-Min Wang, Jian-Kang Jiang, Min Shi
Tetrahedron: Asymmetry | 1999 | 10.1016/s0957-4166(99)00259-1

Abstract An efficient synthetic method for the construction of trans-tetrahydrofuran (THF) unit from trans-1,5,9-decatriene was successfully developed by means of Sharpless AD reactions and oxidative cyclizations catalyzed by Co(modp)2 under an oxygen...


An efficient method for the preparation of N,N-disubstituted 1,2-diamines

Judith M Mitchell, Nathaniel S Finney
Tetrahedron Letters | 2000 | 10.1016/s0040-4039(00)01501-x



Total Synthesis of Spirobacillene A

James D. Cuthbertson, William P. Unsworth, Richard J. K. Taylor
Organic Letters | 2013 | 10.1021/ol4013958

The first total synthesis of spirobacillene A, an indole alkaloid isolated from Lysinibacillus fusiformis, is reported. A Lewis acid mediated spirocyclization of an anisole derivative onto a tethered ynone was used as a key step, drawing inspiration from a...


Structure−Activity Relationships of 1-(2-Deoxy-2-fluoro-β- l -arabino- furanosyl)pyrimidine Nucleosides as Anti-Hepatitis B Virus Agents

Hongbum Kim, Chunguang Wang, Ju Sheng Lin, Tianwei Ma, Jinfa Du, M. Gary Newton, Chung K. Chu, Yung Chi Cheng, Kirupa Shanmuganathan, Yong Lian Zhu, S. Balakrishna Pai
Journal of Medicinal Chemistry | 1996 | 10.1021/jm960098l

Since 2‘-fluoro-5-methyl-β-l-arabinofuranosyluracil (l-FMAU) has been shown to be a potent anti-HBV agent in vitro, it was of interest to study the structure−activity relationships of related nucleosides. Thus, a series of...


New Well-Defined Poly(2,7-fluorene) Derivatives:  Photoluminescence and Base Doping

Ranger, M.; Rondeau, R.; Leclerc, M.
Macromolecules | 1997 | 10.1021/ma970920a

Well-defined poly(2,7-fluorene) derivatives have been prepared through palladium-catalyzed couplings between various 9,9-disubstituted or 9-monosubstituted 2,7-dibromofluorenes and 2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9,9-dioctylfluorene....


Comparative Study of Different Cross-Linking Agents for the Immobilization of Functionalized Carbon Nanotubes within a Chitosan Film Supported on a Graphite−Epoxy Composite Electrode

Orlando Fatibello-Filho, Mariana Emilia Ghica, Christopher M. A. Brett, Rasa Pauliukaite
Analytical Chemistry | 2009 | 10.1021/ac900464z

The effectiveness of immobilization of functionalized carbon nanotubes into chitosan using different cross-linking agents has been evaluated. The cross-linkers used were glyoxal (GO), glutaraldehyde (GA), epichlorohydrin (ECH), and...


Bile Acid-Based 1,2,4-Trioxanes: Synthesis and Antimalarial Assessment(1)

Singh, C.; Hassam, M.; Verma, V. P.; Singh, S. A.; Naikade, N. K.; Puri, S. K.; Maulik, P. R.; Kant, R.
Journal of Medicinal Chemistry | 2012 | 10.1021/jm301323k

A new series of bile acid-based trioxanes 23a–d, 24a–d, 25a–d, 26a, 26b, and 26d have been synthesized and assessed for their antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route. The antimalarial activity of these...


Palladium-Catalyzed Silastannation of Secondary Propargylic Alcohols and their Derivatives

Thomas E. Nielsen, Sebastian Le Quement, David Tanner*
Synthesis | 2004 | 10.1055/s-2004-822380

Tanner et al. reported the silastannation reaction of several secondary terminal propargylic alcohols (protected and unprotected) with Pd2(dba)3•CHCl3/ Ph3P (1-2 equivalents of per Pd). Excellent regio and stereoselectivity (cis addition with tin always...


Mo(CO) 3 (CN- t- Bu) 3 (MoBI 3 ), a New Efficient Catalyst for Regioselective Hydrostannations

Dagmar Schauss, Matthias Pohlman, Uli Kazmaier
Organic Letters | 1999 | 10.1021/ol990794q

Mo(CO) 3 (NC-t-Bu) 3 was found to be a suitable catalyst for the regioselective hydrostannation of several types of alkynes, giving preferentially rise to the α-stannylated products. These products are not available under radical reaction conditions or by...


Facile Synthesis of Structurally Diverse 3,3′-Disubstituted 1,1′-Binaphthyl-2,2′-diamines in Optically Pure Forms

Taichi Kano, Youhei Tanaka, Kenta Osawa, Taiga Yurino, Keiji Maruoka
The Journal of Organic Chemistry | 2008 | 10.1021/jo8011368

A new synthetic route to 3,3′-dihalo BINAMs based on the direct halogenation of H 8 -BINAM and subsequent rearomatization to the binaphthyl core has been developed. The combination of this new procedure and Pd-catalyzed coupling reactions enabled us to...


An Efficient Method for Solution-Phase Parallel Synthesis of 2-Quinoxalinol Salen Schiff-Base Ligands

Anne E. V. Gorden, Xianghong Wu
Journal of Combinatorial Chemistry | 2007 | 10.1021/cc070021q

A solution-phase parallel method for the synthesis of 2-quinoxalinol salen ligands was designed and optimized. The synthesis begins with commercially available 1,5-difluoro-2, 4-dinitrobenzene (DFDNB) and employs a sequence of five straightforward and...


Design of Narrow-Bandgap Polymers. Syntheses and Properties of Monomers and Polymers Containing Aromatic-Donor and o -Quinoid-Acceptor Units

Yoshiro Yamashita, Chitoshi Kitamura, Shoji Tanaka
Chemistry of Materials | 1996 | 10.1021/cm950467m

A series of novel monomers and polymers containing aromatic-donor and o-quinoid-acceptor units was prepared, and the relationship between their spectral and electrochemical properties and their structures was investigated. X-ray structure analyses of the...


A Practical Synthesis of 3,3‐Difluorocyclobutane Carboxylic Acid

Dirk Elend, David Fengas, M. Jonathan Fray
Synthetic Communications | 2005 | 10.1081/scc-200050350

Abstract: We reported a straightforward, three step synthesis of 3,3-difluorocyclobutane carboxylic acid.


Preparation of meta-polyaniline and its related poly(iminoarylene)s by nickel-catalyzed polycondensation of aryl dichlorides with aryl primary diamines

Takaki Kanbara, Yuko Miyazaki1, Kiyoshi Hasegawa, Takakazu Yamamoto
Journal of Polymer Science Part A: Polymer Chemistry | 2000 | 10.1002/1099-0518(20001201)38:23<4194::AID-POLA40>3.0.CO;2-G



Synthesis of the Selective D 2 Receptor Agonist PNU-95666E from d -Phenylalanine Using a Sequential Oxidative Cyclization Strategy

William H. Darlington, Arthur G. Romero, Moses W. McMillan
The Journal of Organic Chemistry | 1997 | 10.1021/jo970526a

Compound 1 (PNU-95666E) is a selective and high-affinity agonist at the dopamine D 2 receptor subtype and is of interest as a potential agent for the treatment of Parkinson's disease. Requiring a synthetic route amenable to scale-up, a synthesis of this...


Highly Chemoselective Reduction of Amides (Primary, Secondary, Tertiary) to Alcohols using SmI2/Amine/H2O under Mild Conditions

Michal Szostak, Malcolm Spain, Andrew J. Eberhart, David J. Procter
Journal of the American Chemical Society | 2014 | 10.1021/ja412578t

Highly chemoselective direct reduction of primary, secondary, and tertiary amides to alcohols using SmI 2 /amine/H 2 O is reported. The reaction proceeds with C–N bond cleavage in the carbinolamine intermediate, shows excellent functional group tolerance, and...


PtCl 2 -Catalyzed Rearrangement of Methylenecyclopropanes

Alois Fürstner, Christophe Aïssa
Journal of the American Chemical Society | 2006 | 10.1021/ja061392y

Alkylidenecyclopropanes readily convert into cyclobutene derivatives on treatment with catalytic amounts of PtCl 2 . The reaction is strongly accelerated when performed under an atmosphere of CO (1 atm). The resulting cyclobutenes are isolated in good to...

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