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A Liquid Chromatography/Mass Spectrometry Method for Screening Disulfide Tethering Fragments

Kenneth K. Hallenbeck, Julia L. Davies, Connie Merron, Pierce Ogden, Eline Sijbesma, Christian Ottmann, Adam R. Renslo, Christopher Wilson, Michelle R. Arkin
SLAS DISCOVERY: Advancing the Science of Drug Discovery | 2017 | 10.1177/2472555217732072

We report the refinement of a high-throughput, liquid chromatography/mass spectrometry (LC/MS)–based screening method for the identification of covalent small-molecule binders to proteins. Using a custom library of 1600 disulfide-capped fragments targeting...

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