With Tag: Physical And Theoretical Chemistry

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Direct observation of a borane–silane complex involved in frustrated Lewis-pair-mediated hydrosilylations

Juha Hurmalainen, Akseli Mansikkamäki, Warren E. Piers, Adrian Y. Houghton, Heikki M. Tuononen
Nature Chemistry | 2014 | 10.1038/nchem.2063

Perfluorarylborane Lewis acids catalyse the addition of silicon–hydrogen bonds across C=C, C=N and C=O double bonds. This ‘metal-free’ hydrosilylation has been proposed to occur via borane activation of the silane Si–H bond, rather than through classical...


Geometric and electronic structure and reactivity of a mononuclear ‘side-on’ nickel(iii)–peroxo complex

Jaeheung Cho, Ritimukta Sarangi, Jamespandi Annaraj, Sung Yeon Kim, Minoru Kubo, Takashi Ogura, Edward I. Solomon, Wonwoo Nam
Nature Chemistry | 2009 | 10.1038/nchem.366

Metal-dioxygen adducts, such as metal-superoxo and -peroxo species, are key intermediates often detected in the catalytic cycles of dioxygen activation by metalloenzymes and biomimetic compounds. The synthesis and spectroscopic characterization of an end-on...


Using small molecules to facilitate exchange of bicarbonate and chloride anions across liposomal membranes

Jeffery T. Davis, Philip A. Gale, Oluyomi A. Okunola, Pilar Prados, Jose Carlos Iglesias-Sánchez, Tomás Torroba, Roberto Quesada
Nature Chemistry | 2009 | 10.1038/nchem.178

Bicarbonate is involved in a wide range of biological processes, which include respiration, regulation of intracellular pH and fertilization. In this study we use a combination of NMR spectroscopy and ion-selective electrode techniques to show that the...


Organic superconductors: Turning on hydrocarbons

Neil Withers
Nature Chemistry | 2010 | 10.1038/nchem.624

The intercalation of potassium into a simple aromatic hydrocarbon results in a new class of organic superconductors.


Fluorescent sensors: Bright ideas

A. Prasanna De Silva
Nature Chemistry | 2012 | 10.1038/nchem.1360

Sensing neuronal activity using fluorescence has many potential advantages over current methods. Now, by taking advantage of photoinduced electron transfer, fluorescent sensors have been developed that allow high-fidelity recording of neural signals in real...


Boron acid: The superacid test

Neil Withers
Nature Chemistry | 2009 | 10.1038/nchem.232

Superacids are defined as being stronger acids than pure sulfuric acid, and can be used to stabilize otherwise reactive cations. Carboranes were recently shown to be superacids and have the added benefit of very low nucleophilicity and redox activity, thus...


Organometallic chemistry: Activating in concert

Paul MacLellan
Nature Chemistry | 2014 | 10.1038/nchem.1866

Nature 505, 199–203 (2014) Making complex and highly functionalized molecules from simple, relatively unreactive substrates is a goal of many modern synthetic techniques. The development of protocols that activate C–H bonds for reaction have in recent years...


Supramolecular chemistry: Another piece of the |[pi]|

Gavin Armstrong
Nature Chemistry | 2009 | 10.1038/nchem.117

Aromatic |[pi]|–|[pi]| interactions are important to many biological functions, including stabilizing the structure of DNA and in the binding of ligands to enzyme active sites. Although much of the previous work to understand the nature of such interactions...


Electron microscopy: Gold rush

Claire Hansell
Nature Chemistry | 2014 | 10.1038/nchem.2079

Science 345, 909–912 (2014) For many molecules, organic and inorganic alike, X-ray crystallography is arguably the most reliable way to obtain detailed information on the positioning of atoms within the structure. However, crystallography, by definition,...


SnAP reagents for the one-step synthesis of medium-ring saturated N-heterocycles from aldehydes

Michael U. Luescher, Cam-Van T. Vo, Jeffrey W. Bode
Nature Chemistry | 2014 | 10.1038/nchem.1878

Interest in saturated N-heterocycles as scaffolds for the synthesis of bioactive molecules is increasing. Reliable and predictable synthetic methods for the preparation of these compounds, especially medium-sized rings, are limited. We describe the...


Protein melts: A new phase for protein chemistry

Douglas S. Clark
Nature Chemistry | 2010 | 10.1038/nchem.746

Proteins are most at home in water, although it has been known for some time that they can remain functional in non-aqueous environments. Researchers have now shown that in solvent-free melts, the oxygen-binding protein myoglobin adopts a near-native...


Ultracapacitors: Graphene gadgets

Tim Reid
Nature Chemistry | 2008 | 10.1038/nchem.67

Electrochemical double-layer capacitors, otherwise known as ultracapacitors, have been proposed as energy-storage devices that could absorb and release power almost instantaneously. Rodney Ruoff and colleagues at the University of Texas, Austin, have...


M|[ouml]|bius aromaticity and antiaromaticity in expanded porphyrins

Zin Seok Yoon, Atsuhiro Osuka, Dongho Kim
Nature Chemistry | 2009 | 10.1038/nchem.172

Aromaticity is a key concept in chemistry, dating back to Faraday's discovery of benzene in 1825 and Kekulé's famous alternating-double-bond structure of 1865. In 1858, the Möbius strip was discovered by Möbius and Listing. The Hückel rules for predicting...


Hydrolytic catalysis and structural stabilization in a designed metalloprotein

Vincent L. Pecoraro, Anna F. A. Peacock, Melissa L. Zastrow, Jeanne A. Stuckey
Nature Chemistry | 2012 | 10.1038/nchem.1201

Metal ions are an important part of many natural proteins, providing structural, catalytic and electron transfer functions. Reproducing these functions in a designed protein is the ultimate challenge to our understanding of them. Here, we present an...


Ultrafast vibrational energy transfer at the water/air interface revealed by two-dimensional surface vibrational spectroscopy

Mischa Bonn, Lukasz Piatkowski, Huib J. Bakker, Zhen Zhang
Nature Chemistry | 2011 | 10.1038/nchem.1158

Water is very different from liquids of similar molecular weight, and one of its unique properties is the very efficient transfer of vibrational energy between molecules, which arises as a result of strong dipole–dipole interactions between the O–H...


Template synthesis of precisely monodisperse silica nanoparticles within self-assembled organometallic spheres

Makoto Fujita, Sota Sato, Kosuke Suzuki
Nature Chemistry | 2010 | 10.1038/nchem.446

One of the key challenges in materials science is to control the size and shape of inorganic nanoparticles with a high degree of precision, as these parameters have a significant influence on the nanoparticles' properties and potential applications. Here, we...


An AAAA–DDDD quadruple hydrogen-bond array

Patrick I. T. Thomson, Christopher A. Hunter, David A. Leigh, Barry A. Blight, Hamish McNab
Nature Chemistry | 2011 | 10.1038/nchem.987

Secondary electrostatic interactions between adjacent hydrogen bonds can have a significant effect on the stability of a supramolecular complex. In theory, the binding strength should be maximized if all the hydrogen-bond donors (D) are on one component and...


Hydrogen bonding: Attractive arrays

Andrew J. Wilson
Nature Chemistry | 2011 | 10.1038/nchem.996

Two readily accessible synthetic building blocks are shown to form a quadruply hydrogen-bonded heterodimer that exhibits exceptional stability and offers new opportunities for the construction of supramolecular assemblies and polymers.


A concentric planar doubly π-aromatic B19− cluster

Alexander I. Boldyrev, Boris B. Averkiev, Hua-Jin Zhai, Alina P. Sergeeva, Wei Huang, Lai-Sheng Wang
Nature Chemistry | 2010 | 10.1038/nchem.534

Atomic clusters often show unique, size-dependent properties and have become a fertile ground for the discovery of novel molecular structures and chemical bonding. Here we report an investigation of the B 19 cluster, which shows chemical bonding...


In situ quantitative imaging of cellular lipids using molecular sensors

Svetlana Kurilova, Wonhwa Cho, Youngdae Yoon, Park J. Lee
Nature Chemistry | 2011 | 10.1038/nchem.1163

Membrane lipids are dynamic molecules that play important roles in cell signalling and regulation, but an in situ imaging method for quantitatively tracking lipids in living cells is lacking at present. Here, we report a new chemical method of quantitative...

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