With Tag: Physical And Theoretical Chemistry

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A potential energy surface bifurcation in terpene biosynthesis

Young J. Hong, Dean J. Tantillo
Nature Chemistry | 2009 | 10.1038/nchem.287

Terpenes comprise a class of natural products that includes molecules with thousands of distinct structurally and stereochemically complex molecular architectures. The core hydrocarbon frameworks of these molecules are constructed via carbocation...


Heterogeneous catalysis: Teaching an old material new tricks

Elio Giamello
Nature Chemistry | 2012 | 10.1038/nchem.1486

A classic calcium aluminate has been modified to create an inorganic electride that can be used as a promoter of the catalytic synthesis of ammonia.


Iron complexes: Rieske business

Laura Croft
Nature Chemistry | 2009 | 10.1038/nchem.280

Iron–sulfur clusters are common cofactors in biological systems and are involved in a range of functions, including electron transfer, substrate binding and activation. These clusters are usually ligated by the cysteine residues of a protein, but there are a...


Diphosphenido ligands: Short and straight

Neil Withers
Nature Chemistry | 2009 | 10.1038/nchem.293

There has been only one example reported so far of a terminal phosphorus monoxide complex. The chemistry of this functional group, therefore, is unexplored compared with others containing main-group elements.


Rapid assembly of complex cyclopentanes employing chiral, α,β-unsaturated acylammonium intermediates

Khoi N. Van, Morgan E. Shirley, Daniel Romo, Rae Lynn McFarlin, Gang Liu
Nature Chemistry | 2013 | 10.1038/nchem.1788

With the intention of improving synthetic efficiency, organic chemists have turned to bioinspired organocascade or domino processes that generate multiple bonds and stereocentres in a single operation. However, despite the great importance of substituted...


The synthesis, crystal structure and charge-transport properties of hexacene

Teruo Shinmyozu, Yuan Jay Chang, Ting-Han Chao, Shun-Wei Liu, Tahsin J. Chow, Chih-Hsien Yuan, Md. Minarul Islam, Kenta Goto, Motonori Watanabe, Yu-Tai Tao
Nature Chemistry | 2012 | 10.1038/nchem.1381

Acenes can be thought of as one-dimensional strips of graphene and they have the potential to be used in the next generation of electronic devices. However, because acenes larger than pentacene have been found to be unstable, it was generally accepted that...


Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates

Seung Seo Lee, Filip J. Wyszynski, Mervyn J. Bibb, Gideon J. Davies, Juan Pablo Gomez-Escribano, Benjamin G. Davis, Hua Wang, Tomoaki Yabe, Soo Jae Lee
Nature Chemistry | 2012 | 10.1038/nchem.1351

The tunicamycins are archetypal nucleoside antibiotics targeting bacterial peptidoglycan biosynthesis and eukaryotic protein N-glycosylation. Understanding the biosynthesis of their unusual carbon framework may lead to variants with improved selectivity....


Cloud-based simulations on Google Exacycle reveal ligand modulation of GPCR activation pathways

Kai J. Kohlhoff, Gregory R. Bowman, Morgan Lawrenz, Dan Belov, Diwakar Shukla, David E. Konerding, Russ B. Altman, Vijay S. Pande
Nature Chemistry | 2014 | 10.1038/nchem.1821

Simulations can provide tremendous insight into the atomistic details of biological mechanisms, but micro- to millisecond timescales are historically only accessible on dedicated supercomputers. We demonstrate that cloud computing is a viable alternative that...


Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research

Thomas J. Boltje, Therese Buskas, Geert-Jan Boons
Nature Chemistry | 2009 | 10.1038/nchem.399

Synthetic oligosaccharides and glycoconjugates are increasingly used as probes for biological research and as lead compounds for drug and vaccine discovery. These endeavours are, however, complicated by a lack of general methods for the routine preparation of...


Crystal engineering: DNA in 3D

Stuart Cantrill
Nature Chemistry | 2009 | 10.1038/nchem.393

Although it is more commonly referred to as the building block of life, DNA is also a useful construction material for building well-defined geometric structures at very small scales. Clever combinations of DNA strands with sequences that are designed to...


Palladium-mediated intracellular chemistry

Emma M. V. Johansson, Asier Unciti-Broceta, Rahimi M. Yusop, Mark Bradley, Rosario M. Sánchez-Martín
Nature Chemistry | 2011 | 10.1038/nchem.981

Many important intracellular biochemical reactions are modulated by transition metals, typically in the form of metalloproteins. The ability to carry out selective transformations inside a cell would allow researchers to manipulate or interrogate innumerable...


Metal-organic frameworks: A porous maze

David S Sholl
Nature Chemistry | 2011 | 10.1038/nchem.1054

Observing the diffusion of guest molecules in large single crystals of a metal-organic framework reveals surprising insights into the blockage of the channels at the material's surface and the role of defects within its bulk.


Switching on the fluorescence of 2-aminopurine by site-selective microhydration

Rajeev K. Sinha, Hans-Martin Frey, Susan Blaser, Samuel Leutwyler, Simon Lobsiger
Nature Chemistry | 2014 | 10.1038/nchem.2086

​2-Aminopurine (​2AP) is a fluorescent isomer of ​adenine and has a fluorescence lifetime of ~11 ns in water. It is widely used in biochemical settings as a site-specific fluorescent probe of DNA and RNA structure and base-flipping and -folding. These assays...


W for tungsten and wolfram

Pilar Goya, Nazario Martín, Pascual Román
Nature Chemistry | 2011 | 10.1038/nchem.1014



Ligand-enabled multiple absolute stereocontrol in metal-catalysed cycloaddition for construction of contiguous all-carbon quaternary stereocentres

Kohsuke Ohmatsu, Naomichi Imagawa, Takashi Ooi
Nature Chemistry | 2014 | 10.1038/nchem.1796

The development of a general catalytic method for the direct and stereoselective construction of contiguous all-carbon quaternary stereocentres remains a formidable challenge in chemical synthesis. Here, we report a highly enantio- and diastereoselective...


A grossly warped nanographene and the consequences of multiple odd-membered-ring defects

Katsuaki Kawasumi, Yasutomo Segawa, Lawrence T. Scott, Kenichiro Itami, Qianyan Zhang
Nature Chemistry | 2013 | 10.1038/nchem.1704

Graphite, the most stable form of elemental carbon, consists of pure carbon sheets stacked upon one another like reams of paper. Individual sheets, known as graphene, prefer planar geometries as a consequence of the hexagonal honeycomb-like arrangements of...


Heterogeneous organocatalysis: Catalytic cloth

Paul MacLellan
Nature Chemistry | 2013 | 10.1038/nchem.1791

Science 341, 1225–1229 (2013) Organocatalysis, the use of small organic molecules to catalyse chemical reactions, offers synthetic chemists the ability to accomplish challenging chemical transformations without the need for expensive, toxic or environmentally...


Nanocrystalline intermetallics on mesoporous carbon for direct formic acid fuel cell anodes

Reanne Holden, Lei Zhang, Martin Couillard, Xiulei Ji, Linda F. Nazar, Gianluigi A. Botton, Jiujun Zhang, Kyu Tae Lee
Nature Chemistry | 2010 | 10.1038/nchem.553

Shape- and size-controlled supported metal and intermetallic nanocrystallites are of increasing interest because of their catalytic and electrocatalytic properties. In particular, intermetallics PtX (X = Bi, Pb, Pd, Ru) are very attractive because of their...


Protein recognition: Calixarene connection

Thomas Schrader
Nature Chemistry | 2012 | 10.1038/nchem.1386

Supramolecular ligands are promising tools for interacting with proteins, but how exactly they bind together has so far been difficult to characterize. An unambiguous picture of the interaction between a synthetic ligand and the surface of cyctochrome c has...


Homogeneous catalysis: Going for gold(III)

Stephen Davey
Nature Chemistry | 2009 | 10.1038/nchem.211

The homogeneous catalytic activity of gold complexes is usually only dependent on the reaction of gold(I) species in solution, and their reaction with electron-rich substrates such as allenes and alkynes. Other transition metals such as palladium and nickel...

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