Enzymatic Synthesis of 7-Deoxy-N-acetylneuraminic Acid and 7-O-Methyl-N-acetylneuraminic Acid

  • Tetrahedron: Asymmetry
  • p 2437-2442, Volume 5, Issue 12,
  • Article


Modifications implemented to improve yields

I used the published synthethic methods for both deoxy and methoxy derivatives with some modifications and obtained a lot higher yields.

Deoxy: 2 eq of 1,1′-Thiocarbonyldiimidazole is enough (paper is 2.5 eq) and I used 1,2-dichloroethane instead of CH2Cl2 and does not have...