Enzymatic Synthesis of 7-Deoxy-N-acetylneuraminic Acid and 7-O-Methyl-N-acetylneuraminic Acid

Randall L. Hakomb; Wolfgang Fitz; Chi-huey Wang

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09 Dec 2016

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I used the published synthethic methods for both deoxy and methoxy derivatives with some modifications and obtained a lot higher yields.

Deoxy: 2 eq of 1,1′-Thiocarbonyldiimidazole is enough (paper is 2.5 eq) and I used 1,2-dichloroethane instead of CH2Cl2 and does not have...

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