| /paper/id/133659 | 0.000000 | 0.000000 |
| INIT | 0.000215 | 0.000215 |
| _initView | 0.001025 | 0.001240 |
| _initViewBasic | 0.000157 | 0.001397 |
| _initSiteModules | 0.000144 | 0.001541 |
| _initRouters | 0.000173 | 0.001714 |
| Sess + | 0.001387 | 0.003101 |
| Sess _ | 0.000100 | 0.003201 |
| pre dispatch _ | 0.000135 | 0.003336 |
| LC::idAction START | 0.000228 | 0.003564 |
| LC::idAction END to showListing | 0.006672 | 0.010236 |
| LC::showListing START | 0.000004 | 0.010240 |
| LC::showListing get reviews START | 0.000014 | 0.010254 |
| ES Review Search START | 0.000559 | 0.010813 |
| ES Review Search END | 0.006942 | 0.017755 |
| LC::showListing get reviews END | 0.000879 | 0.018634 |
| Done | 0.026437 | 0.045071 |
Modifications implemented to improve yields
I used the published synthethic methods for both deoxy and methoxy derivatives with some modifications and obtained a lot higher yields.
Deoxy: 2 eq of 1,1′-Thiocarbonyldiimidazole is enough (paper is 2.5 eq) and I used 1,2-dichloroethane instead of CH2Cl2 and does not have...