Enzymatic Synthesis of 7-Deoxy-N-acetylneuraminic Acid and 7-O-Methyl-N-acetylneuraminic Acid

Randall L. Hakomb; Wolfgang Fitz; Chi-huey Wang

Paper Rating

Reproducibility

Clarity

Versatility

Paper Details

09 Dec 2016

(0)

Reproducibility

Clarity

Versatility

Innovation

I used the published synthethic methods for both deoxy and methoxy derivatives with some modifications and obtained a lot higher yields.

Deoxy: 2 eq of 1,1′-Thiocarbonyldiimidazole is enough (paper is 2.5 eq) and I used 1,2-dichloroethane instead of CH2Cl2 and does not have...

/paper/id/133659	0.000000	0.000000
INIT	0.002672	0.002672
_initView	0.009321	0.011993
_initViewBasic	0.001062	0.013055
_initSiteModules	0.001606	0.014661
_initRouters	0.001755	0.016416
pre dispatch _	0.014030	0.030446
LC::idAction START	0.000247	0.030693
LC::idAction END to showListing	0.026781	0.057474
LC::showListing START	0.000004	0.057478
LC::showListing get reviews START	0.003355	0.060833
ES Review Search START	0.007493	0.068326
ES Review Search END	0.008698	0.077024
LC::showListing get reviews END	0.002193	0.079217
Done	0.037445	0.116662