Synthesis of Ethyl (1S,2R,3S,4S,5S)-2,3-O-(Isopropylidene)-4-Hydroxy-Bicyclo[3.1.0]Hexane-Carboxylate from L-Ribose: A Versatile Chiral Synthon for Preparation of Adenosine and P2 Receptor Ligands
Substitution of the ribose moiety of various nucleosides and nucleotides with the (N)-methanocarba ring system increases the potency and selectivity as ligands at certain subtypes
of adenosine and P2 receptors.
The article is about versatile synthetic strategy for preparing enantiomerically pure (N)-methanocarba ring containing monophosphates as a potent agonist for P2 receptors.
I have successfully reproduced the synthesis of compound (2, MRS2339) from intermidiate compound (12).
Convenient and reproducible synthetic methodology for North configured ribose containing mono phosphate
I have successfully reproduced the synthesis of compound (2, MRS2339) from intermidiate compound (12).