Synthesis of Ethyl (1S,2R,3S,4S,5S)-2,3-O-(Isopropylidene)-4-Hydroxy-Bicyclo[3.1.0]Hexane-Carboxylate from L-Ribose: A Versatile Chiral Synthon for Preparation of Adenosine and P2 Receptor Ligands

  • 10.1080/15257770701845253
  • Nucleosides, Nucleotides and Nucleic Acids
  • p 279-291, Volume 27, Issue 3,
  • journal-article
Substitution of the ribose moiety of various nucleosides and nucleotides with the (N)-methanocarba ring system increases the potency and selectivity as ligands at certain subtypes of adenosine and P2 receptors.


Convenient and reproducible synthetic methodology for North configured ribose containing mono phosphate

The article is about versatile synthetic strategy for preparing enantiomerically pure (N)-methanocarba ring containing monophosphates as a potent agonist for P2 receptors. 

I have successfully reproduced the synthesis of compound (2, MRS2339) from intermidiate compound (12).