Synthesis of Ethyl (1S,2R,3S,4S,5S)-2,3-O-(Isopropylidene)-4-Hydroxy-Bicyclo[3.1.0]Hexane-Carboxylate from L-Ribose: A Versatile Chiral Synthon for Preparation of Adenosine and P2 Receptor Ligands
Bhalchandra V. Joshi, Artem Melman, Richard L. Mackman, Kenneth A. Jacobson
Substitution of the ribose moiety of various nucleosides and nucleotides with the (N)-methanocarba ring system increases the potency and selectivity as ligands at certain subtypes
of adenosine and P2 receptors.
The article is about versatile synthetic strategy for preparing enantiomerically pure (N)-methanocarba ring containing monophosphates as a potent agonist for P2 receptors.
I have successfully reproduced the synthesis of compound (2, MRS2339) from intermidiate compound (12).
Convenient and reproducible synthetic methodology for North configured ribose containing mono phosphate
The article is about versatile synthetic strategy for preparing enantiomerically pure (N)-methanocarba ring containing monophosphates as a potent agonist for P2 receptors.
I have successfully reproduced the synthesis of compound (2, MRS2339) from intermidiate compound (12).
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