• 10.1073/pnas.97.17.9367
  • Proceedings of the National Academy of Sciences
  • p 9367-9372, Volume 97, Issue 17,
  • journal-article

Review

Important contribution to fragment hit-finding technologies

This paper by Erlanson and colleagues describes the disulfide tethering technique, which has proven to be a reproducible and versatile method for finding fragment hits. The main advance is the covalent targeting of the fragment library to a specific site on a protein surface....