Non-equilibrium cobalt(III) “click” capsules

  • 10.1039/C4SC03036B
  • Chem. Sci.
  • p 7-5, 6, 1,
Cobalt( III ) tetrahedral capsules have been prepared using an assembly-followed-by-oxidation protocol from a cobalt( II ) precursor and a readily derivatizable pyridyl-triazole ligand system. Experiments designed to probe the constitutional dynamics show that these architectures are in a non-equilibrium state. A preliminary investigation into the host–guest chemistry of a water-soluble derivative shows it can bind and differentiate a range of different neutral organic molecules. The stability of this ensemble also permits the study of guest-binding at high salt concentrations.