A fast and oxygen-promoted protocol for the ligand-free Suzuki reaction of 2-halogenated pyridines in aqueous media

  • 10.1039/B912364D
  • Chemical Communications
  • p 6267-6267, Volume , Issue 41,
  • journal-article
A fast protocol has been developed for the construction of 2-aryl-substituted pyridine derivatives by the oxygen-promoted, ligand-free, Pd(OAc)2-catalyzed Suzuki reaction of 2-halogenated pyridines in aqueous isopropanol.

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Best method to make various 2-phenylpyridine derivatives

Review :-

1) Synthesized all compounds from Table 1 (1-8) and Table 2 (1-13). I was able to achieve higher yields than the ones reported in this paper by doubling the catalyst concentration.

2) I used excess i.e 3 mol % Palladium acetate than the reported 1.5 mol % for...

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