Cobalt-Catalyzed Arylzincation of Alkynes

  • 10.1021/ol900883j
  • Org. Lett.
  • p 2-3, 11 (11), Issue 11,
  • Letter
Cobalt(II) bromide catalyzes arylzincation of alkynes with arylzinc iodideā€¢lithium chloride complexes in acetonitrile. The scope of the arylzincation is wide enough to use unfunctionalized alkynes, such as 6-dodecyne, as well as arylacetylenes. The inherent functional group compatibility of arylzinc reagents allows preparation of various functionalized styrene derivatives. The reaction is applicable to the efficient and stereoselective synthesis of a synthetic estrogen and its derivative.