Total Synthesis of Spirobacillene A

  • 10.1021/ol4013958
  • Organic Letters
  • p 3306-3309, Volume 15, Issue 13,
  • journal-article
The first total synthesis of spirobacillene A, an indole alkaloid isolated from Lysinibacillus fusiformis, is reported. A Lewis acid mediated spirocyclization of an anisole derivative onto a tethered ynone was used as a key step, drawing inspiration from a potential biosynthesis of the natural product.

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Replicable (w/ Minor Modifications)

This paper was about first total synthesis of an indole alkaloid, Spirobacillene A and the key step of this approach was a Lewis acid catalyzed spirocyclization of an anisole derivative onto a tethered ynone.

I tried to replicate some of these reactions mentioned in this...

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