Geminal Alkene–Alkyne Cross Metathesis Using a Relay Strategy

  • 10.1021/ol301846q
  • Org. Lett.
  • p 4-1, 14 (16), Issue 16,
  • Letter
A relay strategy was employed to achieve an intermolecular ene–yne metathesis between 1,1-disubstituted alkenes and alkynes. The relay serves to activate an unreactive alkene which will not participate in ene-yne metathesis. The new relay cross ene–yne metathesis gives rise to 1,1,3-trisubstituted-1,3-dienes previously inaccessible by direct ene–yne metathesis methods.