Mild Decarboxylative Activation of Malonic Acid Derivatives by 1,1′-Carbonyldiimidazole

  • 10.1021/ol200575c
  • Organic Letters
  • p 2322-2325, Volume 13, Issue 9,
  • journal-article
Malonic acid derivatives undergo unusually mild decarboxylation when treated with N,N′-carbonyldiimidazole (CDI) at room temperature to generate the carbonyl imidazole moiety in high yield, which can be reacted further with a variety of nucleophiles in an efficient one-pot process.


Wide versatility and good reproducibility

This work by Lafrance and co-work represents a very mild means to induce the decarboxylation of malonic acid derivatives with 1,1-carbonyldiimidazole (CDI). The reactive intermediate carbonyl imidazole moiety can be trapped with various nucleophiles in an effcient one-pot...