Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing

  • 10.1021/ol1026848
  • Org. Lett.
  • p 2-8, 13 (2), Issue 2,
  • Letter
A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.