Highly Practical and Enantioselective Cu-Catalyzed Conjugate Addition of Alkylzinc Reagents to Cyclic Enones at Ambient Temperature

  • 10.1021/ol034983r
  • Org. Lett.
  • p 3-2, 5 (18), Issue 18,
  • Letter
A new ligand for Cu-catalyzed enantioselective additions of dialkylzincs to cyclic enones has been developed. In addition to providing good to excellent enantioselectivities with a range of cyclic enones and dialkylzincs, the ligand has several notworthy features:‚ÄČ it can be readily prepared in just two steps, is an air-stable crystalline solid, and provides optimal performance at ambient temperature.