Synthesis and Azidolysis of 2-Chlorotetramethylguanidine. Synthetic Utility of Hexa- and Tetramethylguanidinium Azide

  • 10.1021/jo01343a026
  • The Journal of Organic Chemistry
  • p 1426-1430, Volume 31, Issue 5,
  • journal-article


Good synthesis but experimental lacking some useful details


The preparation of tetramethylguanidium azide was successfully carried out following the literature preparation (JOC 31, 1426 (1966)).  Hydrazoic acid was prepared as a Et2O solution by adding conc HCl over 30 minutes to a ice cold solution of NaN3 in water followed by an...