Enantioselective formation of functionalized 1,3-disubstituted allenes: synthesis of .alpha.-allenic .omega.-carbomethoxy alcohols of high optical purity

Owen W. Gooding, Colin C. Beard, David Y. Jackson, Douglas L. Wren, Gary F. Cooper

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Paper Details

09 Dec 2016

Anonymous

(1)

Reproducibility

Clarity

Versatility

Synthesized (3) and a compound similar to (4) but with protection on -OH groups.

For (3): Dissolving CBr4 in dichloromethane instead of pyridine gave a better yield as it involved using only one solvent throughout the reaction.

For (4): The formation of alkyne group was...

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