Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid: preparation and biological activity

Stephen Priebe , Jeffery B. Nichols , John M. Domagala , Richard W. Skeean , Townley P. Culbertson

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DOI 10.1021/jm00393a004

Journal Journal of Medicinal Chemistry
Location p 1711-1715, Volume 30, Issue 10, 1987
Publication Type journal-article

Tags molecular medicine, drug discovery
Publisher Link Click Here

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09 Dec 2016

Bobbie Dorow

(6)

Procedure Adapted for Better Synthesis

Wanting to avoid a chromatographic separation of the Me esters as well as the greater expense of dimethyl itaconate, the reaction of alpha methyl benzylamine and itaconic acid was performed in xylene. The reaction was performed by adding the amine at 110 to a xylene suspension...

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Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid: preparation and biological activity

Stephen Priebe , Jeffery B. Nichols , John M. Domagala , Richard W. Skeean , Townley P. Culbertson

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Procedure Adapted for Better Synthesis

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