Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications

Peter R. Marsham , Leslie R. Hughes , Ann L. Jackman , Anthony J. Hayter , John Oldfield , J. Michael Wardleworth , Joel A. M. Bishop , Brigid M. O'connor , A. Hilary Calvert

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DOI 10.1021/jm00109a011

Journal Journal of Medicinal Chemistry
Location p 1594-1605, Volume 34, Issue 5, 1991
Publication Type journal-article

Tags molecular medicine, drug discovery
Publisher Link Click Here

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09 Dec 2016

Anonymous

(3)

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Synthesized 2-[N-( tert -Butoxycarbonyl)amino]thiophene (25) and a similar compound (2-[N-( tert -Butoxycarbonyl)amino]-5-bromothiophene) following the same procedure described in the article as method F.

For the synthesis of 25, the reaction was scaled down 100 times, with a...

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Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications

Peter R. Marsham , Leslie R. Hughes , Ann L. Jackman , Anthony J. Hayter , John Oldfield , J. Michael Wardleworth , Joel A. M. Bishop , Brigid M. O'connor , A. Hilary Calvert

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