Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications

Peter R. Marsham, Leslie R. Hughes, Ann L. Jackman, Anthony J. Hayter, John Oldfield, J. Michael Wardleworth, Joel A. M. Bishop, Brigid M. O'Connor, A. Hilary Calvert

Add Review (press R) Confirm Authorship

Paper Rating

Paper Details

DOI 10.1021/jm00109a011

Journal Journal of Medicinal Chemistry
Location p 1594-1605, Volume 34, Issue 5, 1991
Publication Type journal-article

Tags molecular medicine, drug discovery
Publisher Link Click Here

Review

09 Dec 2016

Anonymous

(3)

Reproducible on smaller scale

Synthesized 2-[N-( tert -Butoxycarbonyl)amino]thiophene (25) and a similar compound (2-[N-( tert -Butoxycarbonyl)amino]-5-bromothiophene) following the same procedure described in the article as method F.

For the synthesis of 25, the reaction was scaled down 100 times, with a...

View Detail / Comment

Add Review

/paper/doi/10.1021/jm00109a011	0.000000	0.000000
INIT	0.000253	0.000253
_initView	0.001168	0.001421
_initViewBasic	0.000196	0.001617
_initSiteModules	0.000156	0.001773
_initRouters	0.000157	0.001930
Sess +	0.001507	0.003437
Sess _	0.000110	0.003547
pre dispatch _	0.000143	0.003690
LC::doiAction START	0.000225	0.003915
LC::doiAction END to showListing	0.160622	0.164537
LC::showListing START	0.000004	0.164541
LC::showListing get reviews START	0.000018	0.164559
ES Review Search START	0.000677	0.165236
ES Review Search END	0.006462	0.171698
LC::showListing get reviews END	0.000862	0.172560
Done	0.025207	0.197767

Loading...

Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications

Peter R. Marsham, Leslie R. Hughes, Ann L. Jackman, Anthony J. Hayter, John Oldfield, J. Michael Wardleworth, Joel A. M. Bishop, Brigid M. O'Connor, A. Hilary Calvert

Overall Rating

Review

Reproducible on smaller scale

Recently Reviewed

Has Cited

Cited by

Sign In With