Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications

Peter R. Marsham, Leslie R. Hughes, Ann L. Jackman, Anthony J. Hayter, John Oldfield, J. Michael Wardleworth, Joel A. M. Bishop, Brigid M. O'Connor, A. Hilary Calvert

Add Review (press R) Confirm Authorship

Paper Rating

Paper Details

DOI 10.1021/jm00109a011

Journal Journal of Medicinal Chemistry
Location p 1594-1605, Volume 34, Issue 5, 1991
Publication Type journal-article

Tags molecular medicine, drug discovery
Publisher Link Click Here

Review

09 Dec 2016

Anonymous

(3)

Reproducible on smaller scale

Synthesized 2-[N-( tert -Butoxycarbonyl)amino]thiophene (25) and a similar compound (2-[N-( tert -Butoxycarbonyl)amino]-5-bromothiophene) following the same procedure described in the article as method F.

For the synthesis of 25, the reaction was scaled down 100 times, with a...

View Detail / Comment

Add Review

/paper/doi/10.1021/jm00109a011	0.000000	0.000000
INIT	0.000285	0.000285
_initView	0.001218	0.001503
_initViewBasic	0.000195	0.001698
_initSiteModules	0.000217	0.001915
_initRouters	0.000169	0.002084
Sess +	0.001702	0.003786
Sess _	0.000144	0.003930
pre dispatch _	0.000164	0.004094
LC::doiAction START	0.000238	0.004332
LC::doiAction END to showListing	0.145061	0.149393
LC::showListing START	0.000005	0.149398
LC::showListing get reviews START	0.000021	0.149419
ES Review Search START	0.000759	0.150178
ES Review Search END	0.006932	0.157110
LC::showListing get reviews END	0.000904	0.158014
Done	0.025853	0.183867

Loading...

Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications

Peter R. Marsham, Leslie R. Hughes, Ann L. Jackman, Anthony J. Hayter, John Oldfield, J. Michael Wardleworth, Joel A. M. Bishop, Brigid M. O'Connor, A. Hilary Calvert

Overall Rating

Review

Reproducible on smaller scale

Recently Reviewed

Has Cited

Cited by

Sign In With