A General Synthetic Route to Defined, Biologically Active Multivalent Arrays

  • 10.1021/ja990223t
  • Journal of the American Chemical Society
  • p 6193-6196, Volume 121, Issue 26,
  • journal-article
A new, general strategy for the synthesis of biologically active multivalent arrays displaying diverse functionality has been developed. This method exploits the ability of ring-opening metathesis polymerizations to produce polymers of defined lengths. By incorporating N-hydroxysuccinimide esters into the polymers, recognition epitopes bearing nucleophilic functional groups, in this case an α-mannose derivative, can be attached. The synthesis, characterization, and biological evaluation of mannose-bearing polymers demonstrated the utility of this new methodology. This strategy will facilitate the creation of diverse multivalent libraries and the large-scale production of multidentate ligands.


Good experimental, sub DIC for EDCI

The coupling reaction between a carboxylic acid and an alcohol to generate an ester needs a carbodiimide coupling agent. in the reference, the authors report the use of EDCI to prepare compound 1. I have used the same procedure in the synthesis of 1 though not the pure exo...