Tetraalkylammonium salts in heck-type reactions using an alkali metal hydrogen carbonate or an alkali metal acetate as the base

  • 10.1016/s0040-4039(00)73124-8
  • Tetrahedron Letters
  • p 4103-4106, Volume 35, Issue 24,
  • journal-article


Seminal paper for phase-transfer Heck-Mizoroki cross coupling

A pinacle reaction of the synthesis required the cross coupling off a two highly heteroatom functionalised fragments, the use of traditional Heck conditions, such as palladium (II) acetate, triphenyl phosphine and triethylamine afforded poor yields and irreproducibility. Upon...