Tetraalkylammonium salts in heck-type reactions using an alkali metal hydrogen carbonate or an alkali metal acetate as the base

Tuyet Jeffery , Jean-christophe Galland

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DOI 10.1016/s0040-4039(00)73124-8

Journal Tetrahedron Letters
Location p 4103-4106, Volume 35, Issue 24, 1994
Publication Type journal-article

Tags cross coupling, heck reaction, alkali metals, organic chemistry, biochemistry, drug discovery
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19 Dec 2016

Andrew Lin

(5)

Seminal paper for phase-transfer Heck-Mizoroki cross coupling

Reproducibility

Clarity

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A pinacle reaction of the synthesis required the cross coupling off a two highly heteroatom functionalised fragments, the use of traditional Heck conditions, such as palladium (II) acetate, triphenyl phosphine and triethylamine afforded poor yields and irreproducibility. Upon...

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Tetraalkylammonium salts in heck-type reactions using an alkali metal hydrogen carbonate or an alkali metal acetate as the base

Tuyet Jeffery , Jean-christophe Galland

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Seminal paper for phase-transfer Heck-Mizoroki cross coupling

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