Asymmetric synthesis of (−)-α-conhydrine

  • 10.1016/j.tetasy.2005.08.045
  • Tetrahedron: Asymmetry
  • p 3268-3274, Volume 16, Issue 19,
  • journal-article


Exp. Modification Necessary to Address Variable Yield

In one of my recent projects, I need find a method to convert diethyl malonate-d2 into 3-bromopropanol-d6. Following a literature reported procedure (Eur. J. Org. Chem. 2011, 3339–3346), diethyl malonate-d2 underwent lithium aluminum deuteride (LAD) reduction smoothly to form...