Preparation of some angularly substituted and highly functionalized quinolizidines as building blocks for the synthesis of various alkaloids and related scaffolds of medicinal interest

  • 10.1016/j.tet.2009.07.067
The epimeric forms of the angularly substituted quinolizidine 6 , representing potentially useful building blocks for the synthesis of various alkaloids, have been prepared via a pathway involving two consecutive ring-closing metathesis reactions. Variously hydroxy-protected derivatives (21 , 22 , and 26 –29 ) of these compounds have also been generated.