A Practical Synthesis of Rosuvastatin and Other Statin Intermediates

  • 10.1002/ejoc.201500356
  • European Journal of Organic Chemistry
  • p 4102-4107, Volume 2015, Issue 19,
  • journal-article


Good synthesis method


This paper reports an efficient method for aldol condensation between a methyl 3-hydroxy-5-oxohexanoate derivative and a pyrimidine carbaldehyde comprising the core structure of rosuvastatin. The authors have described the method as an alternative approach to the...