Catalytic Enantioselective Friedel-Crafts Alkylation of Indoles with Nitroalkenes by Using a Simple Thiourea Organocatalyst

  • 10.1002/anie.200500227
  • Angewandte Chemie International Edition
  • p 6-5, 44, 40,
  • journal-article

Review

Good reported synthesis with room for improvement

Review:

This article describes the structure optimization and initial mechanistic understanding of a simple thiourea catalyst for the enantioselective alkylation of indoles with nitroalkenes.  The indole ring has proven to be a “privileged” structure in medicinal chemistry,...

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