| /paper/doi/10.1002/anie.200500227 | 0.000000 | 0.000000 |
| INIT | 0.000212 | 0.000212 |
| _initView | 0.000946 | 0.001158 |
| _initViewBasic | 0.000185 | 0.001343 |
| _initSiteModules | 0.000186 | 0.001529 |
| _initRouters | 0.000162 | 0.001691 |
| Sess + | 0.001669 | 0.003360 |
| Sess _ | 0.000117 | 0.003477 |
| pre dispatch _ | 0.000161 | 0.003638 |
| LC::doiAction START | 0.000242 | 0.003880 |
| LC::doiAction END to showListing | 0.156036 | 0.159916 |
| LC::showListing START | 0.000006 | 0.159922 |
| LC::showListing get reviews START | 0.000024 | 0.159946 |
| ES Review Search START | 0.000680 | 0.160626 |
| ES Review Search END | 0.005385 | 0.166011 |
| LC::showListing get reviews END | 0.000817 | 0.166828 |
| Done | 0.029659 | 0.196487 |
Good reported synthesis with room for improvement
Review:
This article describes the structure optimization and initial mechanistic understanding of a simple thiourea catalyst for the enantioselective alkylation of indoles with nitroalkenes. The indole ring has proven to be a “privileged” structure in medicinal chemistry,...