| /paper/doi/10.1002/anie.200500227 | 0.000000 | 0.000000 |
| INIT | 0.002366 | 0.002366 |
| _initView | 0.008119 | 0.010485 |
| _initViewBasic | 0.000962 | 0.011447 |
| _initSiteModules | 0.001544 | 0.012991 |
| _initRouters | 0.001517 | 0.014508 |
| pre dispatch _ | 0.015141 | 0.029649 |
| LC::doiAction START | 0.000203 | 0.029852 |
| LC::doiAction END to showListing | 0.209984 | 0.239836 |
| LC::showListing START | 0.000004 | 0.239840 |
| LC::showListing get reviews START | 0.002771 | 0.242611 |
| ES Review Search START | 0.006586 | 0.249197 |
| ES Review Search END | 0.009471 | 0.258668 |
| LC::showListing get reviews END | 0.002048 | 0.260716 |
| Done | 0.034175 | 0.294891 |
Good reported synthesis with room for improvement
This article describes the structure optimization and initial mechanistic understanding of a simple thiourea catalyst for the enantioselective alkylation of indoles with nitroalkenes. The indole ring has proven to be a “privileged” structure in medicinal chemistry,...