Catalytic Enantioselective Friedel-Crafts Alkylation of Indoles with Nitroalkenes by Using a Simple Thiourea Organocatalyst

  • 10.1002/anie.200500227
  • Angewandte Chemie International Edition
  • p 6-5, 44, 40,
  • journal-article


Good reported synthesis with room for improvement


This article describes the structure optimization and initial mechanistic understanding of a simple thiourea catalyst for the enantioselective alkylation of indoles with nitroalkenes.  The indole ring has proven to be a “privileged” structure in medicinal chemistry,...