| /paper/doi/10.1002/anie.200500227 | 0.000000 | 0.000000 |
| INIT | 0.002469 | 0.002469 |
| _initView | 0.009490 | 0.011959 |
| _initViewBasic | 0.000946 | 0.012905 |
| _initSiteModules | 0.001746 | 0.014651 |
| _initRouters | 0.001683 | 0.016334 |
| pre dispatch _ | 0.014293 | 0.030627 |
| LC::doiAction START | 0.000213 | 0.030840 |
| LC::doiAction END to showListing | 0.192487 | 0.223327 |
| LC::showListing START | 0.000010 | 0.223337 |
| LC::showListing get reviews START | 0.003344 | 0.226681 |
| ES Review Search START | 0.006818 | 0.233499 |
| ES Review Search END | 0.008440 | 0.241939 |
| LC::showListing get reviews END | 0.003915 | 0.245854 |
| Done | 0.080719 | 0.326573 |
Good reported synthesis with room for improvement
This article describes the structure optimization and initial mechanistic understanding of a simple thiourea catalyst for the enantioselective alkylation of indoles with nitroalkenes. The indole ring has proven to be a “privileged” structure in medicinal chemistry,...