| /paper/doi/10.1002/anie.200500227 | 0.000000 | 0.000000 |
| INIT | 0.002223 | 0.002223 |
| _initView | 0.009656 | 0.011879 |
| _initViewBasic | 0.000901 | 0.012780 |
| _initSiteModules | 0.001524 | 0.014304 |
| _initRouters | 0.001705 | 0.016009 |
| pre dispatch _ | 0.013337 | 0.029346 |
| LC::doiAction START | 0.000186 | 0.029532 |
| LC::doiAction END to showListing | 0.201773 | 0.231305 |
| LC::showListing START | 0.000003 | 0.231308 |
| LC::showListing get reviews START | 0.003265 | 0.234573 |
| ES Review Search START | 0.006073 | 0.240646 |
| ES Review Search END | 0.007831 | 0.248477 |
| LC::showListing get reviews END | 0.001951 | 0.250428 |
| Done | 0.033553 | 0.283981 |
Good reported synthesis with room for improvement
This article describes the structure optimization and initial mechanistic understanding of a simple thiourea catalyst for the enantioselective alkylation of indoles with nitroalkenes. The indole ring has proven to be a “privileged” structure in medicinal chemistry,...