| /paper/doi/10.1002/anie.200500227 | 0.000000 | 0.000000 |
| INIT | 0.002442 | 0.002442 |
| _initView | 0.017112 | 0.019554 |
| _initViewBasic | 0.001021 | 0.020575 |
| _initSiteModules | 0.005566 | 0.026141 |
| _initRouters | 0.001630 | 0.027771 |
| pre dispatch _ | 0.025924 | 0.053695 |
| LC::doiAction START | 0.004270 | 0.057965 |
| LC::doiAction END to showListing | 0.197336 | 0.255301 |
| LC::showListing START | 0.000005 | 0.255306 |
| LC::showListing get reviews START | 0.000014 | 0.255320 |
| ES Review Search START | 0.006383 | 0.261703 |
| ES Review Search END | 0.006679 | 0.268382 |
| LC::showListing get reviews END | 0.002047 | 0.270429 |
| Done | 0.066708 | 0.337137 |
Good reported synthesis with room for improvement
This article describes the structure optimization and initial mechanistic understanding of a simple thiourea catalyst for the enantioselective alkylation of indoles with nitroalkenes. The indole ring has proven to be a “privileged” structure in medicinal chemistry,...