This article describes the structure optimization and initial mechanistic understanding of a simple thiourea catalyst for the enantioselective alkylation of indoles with nitroalkenes. The indole ring has proven to be a “privileged” structure in medicinal chemistry,...
Good reported synthesis with room for improvement
Review:
This article describes the structure optimization and initial mechanistic understanding of a simple thiourea catalyst for the enantioselective alkylation of indoles with nitroalkenes. The indole ring has proven to be a “privileged” structure in medicinal chemistry,...