Overview

SciBase is recruiting a Senior Principle Scientist of Oligonucleotide Chemistry for our partners located in the San Francisco Bay Area.

Responsibilities

• As a project leader, drive and direct oligonucleotide chemistry functions for siRNA, antisense, or other nucleic acid discovery projects, working in concert with partners in molecular and cellular biology, pharmacology, computational chemistry, ADME, structural biology, chemical development, and other key functions
• Serve as a scientific expert in nucleic acid drug discovery with both internal and external partners and provide recommendations regarding new targets and emerging external opportunities
• Provide scientific direction and leadership for oligonucleotide and synthetic chemistry activities of internal & external FTEs
• Supervise and direct synthetic chemistry activities at contract research organizations (CROs)
• Maintain a significant level of knowledge and management of laboratory research, and executes synthesis, purification, and characterization of oligonucleotides in the lab
• Analyze screening data, perform literature reviews, design, propose, and execute nucleic acid chemistry plans, coordinate chemistry and biology data to support oligonucleotide compound progression and patent strategies
• Ensure efficient interaction/communication and provide updates on project status to Discovery Sciences leadership

Skills Required

• PhD in synthetic organic or medicinal chemistry or nucleic acid chemistry or other related chemistry field is required
• Postdoctoral experience with an emphasis in oligonucleotide or nucleoside chemistry is preferred
• At least 6 years experience in the biopharmaceutical or biotechnology industry is required
• A proven track record of leading innovative oligonucleotide discovery projects, especially in siRNA therapeutics, is preferred
• Experience as a project leader in the biopharmaceutical industry is strongly preferred
• Experience in one or more therapeutic areas/oligonucleotide modalities is preferred
• Expert knowledge of modern methods of synthetic chemistry with an emphasis on oligonucleotide synthesis and characterization is preferred
• Expertise in nucleic acid modalities, modification chemistries, sequence selection, and mechanism of action is preferred
• Strong track record of scientific contributions including peer reviewed first-author publications, patent applications, and/or presentations at major national meetings is preferred
• Maintaining a very productive lab presence is required.
• This position may require up to 10% travel